Monitorace 24hodinového krevního tlaku - editorial

V. Adámková

Vnitr Lek 2008, 54(2):129-130  

Může mít význam stanovení hladin natriuretických peptidů u nemocných bez zjevného srdečního selhání? - editorial

R. Pudil

Vnitr Lek 2008, 54(2):131-132  

Invazivní aspergilóza: je čas na optimizmus? - editorial

E. Faber

Vnitr Lek 2008, 54(2):133-134  

Je dyslipidemie rizikovým faktorem pro nemocné léčené antiretrovirovými léky? - editorial

V. Soška

Vnitr Lek 2008, 54(2):135-136  

Infekce tepenných rekonstrukcí - editorial

J. Herman

Vnitr Lek 2008, 54(2):137-138  

Monitoring of anti-tumour cell-mediated response in patients with renal cell carcinoma, disturbance of T cell proliferation

Š. Lukešová, V. Vroblová, D. Hlávková, O. Kopecký, D. Vokurková, P. Morávek, H. Šafránek, P. Souček

Vnitr Lek 2008, 54(2):139-145  

Introduction:When checking tumour growth, a number of observations indicate that the immune system plays a significant role in patients with renal cell carcinoma ("RCC"). Infiltration by lymphocytes (tumour infiltrating lymphocytes, "TILs") is more prevalent in RCC than any other tumours. T lymphocytes are the dominant population of TIL cells. Views concerning the role of T lymphocytic subpopulations, B lymphocytes and NK cells in an anti-tumour response are not established. Aim:The aim is to determine the phenotype and activation of lymphocytic cells and to compare their representation in tumour stroma (TIL), peripheral blood...

Definition of 24hour ambulatory blood pressure values corresponding to office blood pressure values of 130/80 mm Hg

I. Řiháček, M. Souček, P. Fráňa, M. Plachý, A. Vašků, V. Znojil

Vnitr Lek 2008, 54(2):146-149  

Background:Ambulatory blood pressure monitoring (ABPM) provides a profile of blood pressure (BP) away from the medical environment and has been shown to be a stronger predictor of cardiovascular morbidity and mortality than office BP measurement. There are known the normal BP values for ABPM in general population with office BP value 140/90 mm Hg, but don't are known normal values for ABPM of patients with high risk hypertension which needs to have office BP below 130/80 mm Hg. Aim of study: Definition of normal BP value of ABPM in patients with office BP130 and/or 80 mm Hg. Methods:BP measurement in 241 healthy subjects...

Factors related to NT-proBNP values in haemodynamically stable patients with normal systolic function of the left ventricle

M. Vytiska, P. Kala, I. Klabenešová, O. Boček, P. Jeřábek, P. Neugebauer, M. Poloczek, J. Pařenica, O. Ludka, J. Špinar

Vnitr Lek 2008, 54(2):150-155  

Introduction:Increased values of natriuretic peptides are considered prognostically significant in normal population with respect to mortality and the incidence of cardiovascular events, regardless of the left ventricular function. The objective of the study is to point out the factors related to NT-proBNP values in patients without the heart failure syndrome and with normal left ventricular systolic function. Methods:The group consisted of 290 elective patients aged between 50 and 82, with the mean age of 62 years, of whom 47 % were women. The enrolled patients were heamodynamically stable, without a history of MI, with a...

Invasive aspergillosis in hematooncological patients: advantages and disadvantages of various diagnostic methods, treatment options and financial costs of therapy

Z. Ráčil, J. Mayer, I. Kocmanová, B. Wagnerová, J. Winterová, F. Folber, M. Lengerová, M. Moulis, D. Žáčková, L. Šmardová, A. Janíková, M. Navrátil, D. Dvořáková, J. Vorlíček

Vnitr Lek 2008, 54(2):157-168  

Background:Invasive aspergillosis (IA) is a leading invasive fungal infection in hematooncological patients. The aim of this study was to analyse the incidence, diagnostic procedures and treatment of IA in hematooncological department in large hospital in the Czech Republic. Patients and methods:A retrospective analysis of medical and laboratory records from patients hospitalised in our department with proven/probable IA between January 2000 and December 2006 was performed. Results:52 cases of IA in 51 patients were identified (17.3 % proven IA/82.7 % probable IA). Number of IA cases notably increased during...

Dyslipidaemia inducted by antiretroviral agents

S. Snopková, K. Povolná, P. Husa, J. Jarkovský, T. Pavlík

Vnitr Lek 2008, 54(2):169-177  

The clinical course of HIV/AIDS has been substantially modified by up-to date therapy in the recent years. The progress of the disorder has changed - today it is a chronic disease of many years course. Already in 1997 and 1998 it turned out that adverse metabolic changes which significantly affect the subsequent progress of the disease were produced by long-term HAART (highly active antiretroviral therapy). Gradually, more and more anthropometric, metabolic and coagulation changes are detected, closely resembling the changes seen in the metabolic syndrome, well known from cardiology and internal medicine - dyslipoproteinaemia, insulin resistance, abdominal...

Peripheral arterial disease of extremities - guidelines for diagnostic and treatment

V. Štvrtinová, V. Šefránek, J. Murín, A. Dukát, J. Tomka, I. Vulev, O. Bzdúchová, A. Džupina, J. Bilický

Vnitr Lek 2008, 54(2):195-202  

Diagnostic and therapeutic guidelines of peripheral arterial disease of extremities recommanded by five scientific societies of Slovak Medical Association (Slovak Angiological Society, Slovak Society for Vascular Surgery, Slovak Cardiologic Society, Slovak Internal Society and Slovak Radiologic Society) are discussed in this article. Peripheral arterial disease (PAO) of extremities is an important manifestation of systemic atherosclerosis The lower the ankle-brachial pressure index, the greater the risk of serious cardiovascular events (e.g. myocardial infarction, stroke). Nevertheless, patients with PAO are undertreated with regard to use of antiplatelet...

Blood vessel reconstruction infections: a practical view

M. Krejčí, Z. Gregor, Z. Kříž, J. Podlaha, R. Staffa, Z. Konečný, M. Dvořák

Vnitr Lek 2008, 54(2):178-182  

Infection represents a serious complication in vascular surgery. The average of 2-3 % of reconstructions are involved. The article offers a review of current diagnosis and treatment of infection after vascular reconstruction. Emphasis is put on early diagnosis and its impact on prognosis of patients. We summarize the practical potential of surgical treatment. The situation is illustrated by our results from the years 2004-2006. During the last 3 years 19 patients were operated on for infection of the arterial reconstruction (15ways aorto-femoral and 4ways femoro-popliteal bypass). The main agent was Staphylococcus aureus (9 patients, i.e. 47.4...

Current Use of Magnetic Resonance Imaging in Cardiology

M. Solař, J. Žižka, L. Klzo, J. Ceral

Vnitr Lek 2008, 54(2):183-190  

Magnetic resonance imaging is a modern imaging technique that is characterized by high resolution and variable tomographic slices. The development of magnetic resonance technology in last decade led to the expansion of this method in many fields of medicine. In cardiology, the imaging is focused on the heart, aorta, pulmonary, coronary and renal arteries. Dynamic imaging is used for the evaluation of the kinetics and the function of the ventricles. Static imaging serves for the assessment of the myocardial wall in patients with cardiomyopathies and coronary artery disease. The quality of static imaging can improve paramagnetic contrast agent that increasingly...

Importance of the endocannabinoid system in the regulation of energy homeostasis

T. Kvasnička

Vnitr Lek 2008, 54(2):191-194  

The endocannabinoid system is an endogenous signaling system that plays a role in the regulation of energy homeostasis and lipid and glucose metabolism-all of which can influence cardiometabolic risk. The endocannabinoid system appears to be a promising novel mechanistic pathway that modulates important aspects af cardiovascular and metabolic function. The endocannabinoid system is normally a silent physiologic system that becomes transiently activated, that is, only when needed. Evidence suggests that the endocannabinoid system is tonically overactive in human obesity and in animal models of genetic and diet-induced obesity. However, there is evidence...

The scintigraphic ^99mTc-MAA imaging quantification of the right-to-left shunt in a patients with multiple pulmonary arteriovenous malformation and familial teleangiectasis

J. Doležal

Vnitr Lek 2008, 54(2):206-209  

Aim:To present a case report about 57-years-old woman with hypoxemia, multiple pulmonary arteriovenous (AV) malformations and lips teleangiectasis where the right-to-left shunt quantification was assessed by means of whole body scintigraphy with ^99mTc-labelled human macro-aggregated albumin (MAA). Material and Method:A 57-years-old woman underwent X-ray and bolus enhanced lung CT for dyspnoea, hypoxemia and cyanosis. A multiple intrapulmonary arteriovenous malformations were detected. The whole-body ^99mTc-MAA scintigraphy for the right-to-left shunt quantification was performed. The whole-body scintigraphy...

Stejskal D. Urolitiáza

Arne Rovný

Vnitr Lek 2008, 54(2):210  

At least 60 deaths could be avoided in this country every day!

J. Spáčil

Vnitr Lek 2008, 54(2):203-205  

The number of people who die every day from cardiovascular and oncological diseases in this country is by at least 60 deaths higher than in neighbouring Austria or Germany. Data from most industrialized countries clearly show that the incidence of and morbidity related to the above diseases can be reduced by timely diagnosis and modern treatment, and especially by healthy life style. This can be achieved by health education and, first of all, by creating favourable conditions facilitating healthy behaviour. It is necessary to persuade politicians and to win social support and endorsement with their assistance.