Medicína v roce 2008: Je vidět světlo na konci tunelu?

Richard Češka

Vnitr Lek 2008, 54(1):5-6  

Celiakální sprue - editorial

J. Utěšený

Vnitr Lek 2008, 54(1):7  

Memorandum - celiakální sprue (CS) - současný stav a sociální situace nemocných v České republice

Expertní komise ministerstva zdravotnictví pro celiakální sprue (EKCS)

Vnitr Lek 2008, 54(1):8-11  

Fibrilace síní - kardiovaskulární epidemie - editorial

R. Lábrová

Vnitr Lek 2008, 54(1):12-13  

Konvenční léčba fibrilace síní - editorial

M. Novák

Vnitr Lek 2008, 54(1):14-15  

V diagnostice i terapii houbových infekcí nastal v posledních letech velký pokrok, stále však nedostačující - editorial

P. Cetkovský

Vnitr Lek 2008, 54(1):16-18  

Farmakogenetika léčby statiny - editorial

T. Freiberger

Vnitr Lek 2008, 54(1):19-20  

Monitoring age-dependent effect of anticoagulation treatment in patients with atrial fibrillation

T. Hnátek, D. Zogala, L. Kameník, I. Kotík, I. Jeřábek, M. Zavoral

Vnitr Lek 2008, 54(1):21-24  

Oral anticoagulation treatment with dicumarol preparations (warfarin sodium) is the standard in patients with atrial fibrillation. The effect of treatment depends on many factors, especially in elderly patients. In the study, we assessed the effect of treatment in patients with atrial fibrillation hospitalized in our cardiology ward from 2004 to 2005, in the form of a telephone survey (who controlled the treatment - general practitioner or internist?, the last 2 INR results, complications). INR 2.0-3.5 is considered an efficient therapeutic range. The proportion of permanently correctly anticoagulated patients is approximately 47 % across the whole...

Positive tests for serum anti-endomisium antibodies (AEA) and anti-jejunal antibodies (JAB) and histopathological diagnosis of celiac disease in children

P. E. Makovický, P. A. Makovický, M. Klimik, M. Greguš, M. Zimmermann

Vnitr Lek 2008, 54(1):25-30  

Non-invasive examination methods are increasingly important in diagnosing celiac disease. New options for diagnosing celiac disease have been discovered in addition to the established biochemical, hematological and other methods as a result expansive progress of clinical genetics and immunology. At the same time, detection of circulating auto-antibodies is becoming ever more frequent in clinical practice. As a result, many new, clinically highly heterogeneous cases of the disease have been diagnosed and consequently the prevalence of the disease in both child and adult population has grown. Detection of anti-endomysial antibodies (AEA), characteristic...

Assessment of plasmatic cell proliferation and apoptosis indexes in the course of multiple myeloma

J. Minařík, V. Ščudla, M. Ordeltová, J. Bačovský, M. Zemanová, T. Pika

Vnitr Lek 2008, 54(1):31-35  

Introduction:The proliferation and apoptosis indexes are a significant prognostic factor in multiple myeloma (MM). The objective of the study was to assess the indexes in the course of MM from the point of view of the disease activity and potential clinical use. Method:A sample of 120 patients was studies, of which 49 at diagnosis, 36 in progression and 35 in remission. The proliferation and apoptosis indexes were assessed according to the achieved treatment response and were compared with subsequent progression in patients in remission. The proliferation potential was measured with the propidium-iodide index (PC-PI/CD138),...

Conventional treatment of atrial fibrillation in the Czech Republic managed by outpatient cardiologists. Overview of diagnostic and treatment procedures, pharmacological treatment and hospitalisation

V. Bulková, M. Fiala, J. Chovančík, D. Wichterle, R. Čihák, M. Branny, J. Kautzner

Vnitr Lek 2008, 54(1):36-44  

Objective:The aim of the study was to analyse general health data, diagnostic and therapeutic procedures, pharmacological treatment and hospitalization of patients with atrial fibrillation (AF) who did not undergo AF catheter ablation and were in the care of outpatient cardiologists. Method:Data concerning 306 patients (of which 94 women, aged 64 ± 11 years) for the preceding 2 years were acquired through a questionnaire containing a set of standardized questions on a simple form sent out to outpatient cardiologists. Results:AF was paroxysmal, persistent or permanent in 141 (46 %), 77 (25 %) or 88 (28%)...

The use of galactomannan detection in diagnosing invasive aspergilosis in hemato-oncological patients

Z. Ráčil, I. Kocmanová, B. Wagnerová, J. Winterová, M. Lengerová, M. Moulis, J. Mayer

Vnitr Lek 2008, 54(1):45-52  

Premises and objectives:Timely diagnosis is of critical importance for the prognosis of invasive aspergilosis (IA) patients. Over recent years, IA detection of galactomannan using the ELISA method has assumed growing importance. The objective of the study was to analyse the usability of the method in current clinical practice of a hemato-oncological ward. Patients and methods:From May 2003 to October 2006, blood samples were taken from patients at IA risk to detect galactomannan (GM) in serum using the ELISA method. The patients who underwent the tests were classified by the probability of IA presence on the basis of the results...

Recommendations of Czech Rheumatological Society for the treatment of rheumatoid arthritis. Efficacy and treatment strategies

R. Bečvář, J. Vencovský, P. Němec, D. Suchý, L. Procházková, K. Pavelka

Vnitr Lek 2008, 54(1):84-99  

Rheumatoid arthritis (RA) is an autoimmune disease of unknown aetiology characterized by presence of chronic symmetric synovitis, which leads to the formation of joint erosions. Generally recommended method for activity assessment of RA is so called Disease Activity Score (DAS). In early RA when low disease activity is present with oligo- or monoarthritis antimalarials are drugs of choice, while sulfasalazine (SAS) is recommended in cases with medium activity without erosions. Initial treatment with methotrexate (MTX) or leflunomide (LEF) should be applied in a very active polyarthritis with a rapid development of erosions. MTX is often combined with...

Doporučení diagnostických a léčebných postupů u arteriální hypertenze - verze 2007. Doporučení České společnosti pro hypertenzi

J. Widimský jr, R. Cífková, J. Špinar, J. Filipovský, M. Grundmann, K. Horký, A. Linhart, V. Monhart, H. Rosolová, M. Souček, J. Vítovec, J. Widimský sr

Vnitr Lek 2008, 54(1):101-118  

Differentiated approach to prescription of physical activity in patients with left ventricular dysfunction

H. Svačinová, J. Siegelová, P. Dobšák, B. Fišer, L. Mífková, V. Chludilová

Vnitr Lek 2008, 54(1):53-61  

Correctly indicated physical exercise performed and controlled on a regular basis is an inseparable part of treatment and rehabilitation of patients with left ventricular dysfunction. In order to guarantee the best effect and safety of physical exercise, it is necessary to adopt a differential approach to its prescription to patients with different degrees of functional damage. In addition, a number of conditions should be fulfilled, among which, in the first place, the determination of functional classification of patients used in practice and described in the relevant literature (NYHA, AMA, Goldman, Weber). Physical exercise cannot be differentiated...

Statin pharmacokinetics

J. A. Hubáček, V. Adámková, K. Zídková, R. Češka, L. Zlatohlávek, T. Štulc, A. Hořínek, M. Vrablík

Vnitr Lek 2008, 54(1):62-67  

Reducing high levels of plasmatic lipoids (LDL-cholesterol and triglycerides) is one of the most important steps in the prevention and treatment of cardiovascular diseases. In the majority of cases, treatment based on lifestyle changes (changes in dietary habits, more physical activity) is not sufficient and pharmacotherapy becomes necessary. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are a well tolerated first-choice drug in patients with dyslipidemia. However, great variability of statin effects has been observed in different patients on the same therapy, and the cause clearly resides in different genetic characteristics...

The treatment of Waldenström macroglobulinemia and the therapy of diseases caused by monoclonal IgM gammaglobulin

Z. Adam, V. Ščudla, M. Krejčí, Z. Kořístek

Vnitr Lek 2008, 54(1):68-83  

Waldenström macroglobulinemia is defined by the presence of IgM type monoclonal immunoglobulin and histological prove of lymphoplasmocytary lymphoma in the bone marrow. Alkylating cytostatic drugs, chlorambucil or cyclofosfamide in monotherapy have been typically used for its treatment. Similarly to other lymphoproliferative diseases with a low degree of aggressiveness, purine analogues (fludarabine and 2-chlordeoxyadenosine) have a faster treatment response and a higher number of treatment responses, especially if administered in combination with alkylating drugs. The monoclonal antibody rituximab (R) also brings considerable improvement to patients...

Z odborné literatury

Vnitr Lek 2008, 54(1):119-122