Využití implantabilních monitorovacích zařízení v diagnostice synkop nejasné etiologie - editorial

L. Křivan

Vnitr Lek 2007, 53(11):1137-1138  

N-terminální peptid pro-BNP a endotelin u hemodialyzovaných nemocných - editorial

J. Racek

Vnitr Lek 2007, 53(11):1139-1141  

Adiponektin a inzulinová rezistence - editorial

Z. Kováčová, V. Štich, J. Polák

Vnitr Lek 2007, 53(11):1142-1143  

Vplyv obezity na genovú expresiu adiponektínu a jeho receptoru v subkutánnom tukovom tkanive - editorial

D. Gašperíková

Vnitr Lek 2007, 53(11):1144-1146  

Diagnostic benefit of the use of implanted loop recorder (Reveal Plus) for patients with syncope with unclear aetiology

P. Mitro, M. Szakács, J. Bodnár, G. Valočik, P. Kirsch, K. Mudráková

Vnitr Lek 2007, 53(11):1147-1152  

The objective of the study was to evaluate the diagnostic yield of a loop recorder (Reveal Plus, Medtronic) in the diagnosis of syncope conditions whose aetiology remains unclear despite the performance of a full diagnostic procedure. Patients and method:Loop recorders were implanted in 25 patients with recurrent syncope (9 men, 16 women, average age 59 ± 14 years), who reported 4 ± 2.7 episodes of syncope (2-10 episodes). A complete diagnostic algorithm was performed for all patients before implantation including the head-up tilt test, an invasive electrophysiological examination and a neurological examination. The aetiology...

Long term results of cardiac resynchronisation therapy for patients with severe heart failure

A. Bulava, J. Lukl, M. Hutyra, D. Marek

Vnitr Lek 2007, 53(11):1153-1163  

Introduction:Cardiac resynchronisation therapy (CRT) has been shown to be a highly effective treatment strategy for patients with severe chronic heart failure (ChHF). Objective of study:To determine the clinical response of patients to CRT, to measure morbidity and mortality for this population of patients, to determine causes and predictors of death. To test whether the parameters of tissue Doppler echocardiography are able to predict response to CRT. Patients and methods:Before and after implantation of the CRT and 12 months later, echocardiograph tests were carried out and relevant clinical data was recorded...

Utilisation of Glykogen Phosphorylase BB measurement in the diagnosis of acute coronary syndromes in the event of chest pain

B. Lačňák, D. Stejskal, L. Jedelský, M. Karpíšek, L. Šprongl

Vnitr Lek 2007, 53(11):1164-1169  

Introduction:Glykogen Phosphorylase BB is considered a timely and specific marker of acute coronary syndrome. A kit for measuring Glykogen Phosphorylase BB in routine diagnosis has been released recently. Objective of the study:To test the utilisation of Glykogen Phosphorylase BB measurement in the diagnosis of acute coronary syndrome. Method:70 patients with suspected acute coronary syndrome were tested. A final diagnosis of acute coronary syndrome/non-coronary difficulties was made according to ESC/ACC/AHA criteria. Measurements of troponin I, myoglobin and GPBB in venous plasma (heparin-lithium) were taken...

Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) are elevated in peripheral blood plasma of patients with chronic lymphocytic leukemia and decrease after intensive fludarabine-based treatment

L. Smolej, C. Andrýs, J. Krejsek, D. Belada, P. Žák, O. Široký, J. Malý

Vnitr Lek 2007, 53(11):1171-1176  

Chronic lymphocytic leukemia (CLL) is characterized by extraordinary heterogeneity in terms of clinical course with overall survival ranging from several months to dozens of years. It is currently not possible to accurately predict the future clinical course in an individual patient. Angiogenesis has been recently reported as a potential prognostic factor in various hematological malignancies including CLL. The objective of the present study was to quantify plasma levels of key angiogenic activators vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in patients with CLL and determine their potential change after intensive...

Variability of plasmatic levels of big endothelin and NT-proBNP in patients with heart failure in a chronic haemodialysis programme

O. Ludka, J. Špinar, L. Vítovcová, D. Sobotová, L. Špinarová, Z. Pozdíšek, V. Musil, J. Vítovec, J. Tomandl

Vnitr Lek 2007, 53(11):1177-1181  

Inter-dialysis variability in levels of big endothelin and NT-proBNP in plasma were studied in 22 patients with established systolic and/or diastolic dysfunction of the left cardiac ventricle assigned to a chronic haemodialysis programme. The plasmatic level of NT-proBNP in all patients was practically unchanged. There was a falling trended between haemodialysis treatments but this was not statistically significant and in absolute values clinically insignificant. Fluctuations were found between individuals but on average all values were stable and high in the pathological range. No significant changes in the plasmatic level of big endothelin were found...

Endoscopic diagnosis and treatment of biliary complications after laparoscopic cholecystectomy

B. Kianička, P. Dítě, I. Suškevič

Vnitr Lek 2007, 53(11):1182-1189  

Objective of study:The main parameters studied in this retrospective study were the success of diagnoses carried out using endoscopic retrograde cholangiopancreatography (ERCP), the ability of ERCP to precisely determine the cause of complications and the effectiveness and morbidity of therapeutic ERCP. Materials and method:the study covers a period of 7 years (January 1997 - December 2003). The study retrospectively reviewed the histories of 92 patients who underwent laparoscopic cholecystectomy (LCE) and subsequently developed symptoms suggesting possible biliary complications (BC) from previous LCE, and indicating the performance...

The influence of obesity on the gene expression of adiponectin and its receptor in subcutaneous adipose tissue

Z. Lacinová, D. Michalský, M. Kasalický, M. Dolinková, D. Haluzíková, T. Roubíček, J. Krajíčková, M. Mráz, M. Matoulek, M. Haluzík

Vnitr Lek 2007, 53(11):1190-1197  

The objective of the study was to measure the concentration of adiponectin in plasma, its mRNA expression and the expression of the adiponectin receptors AdipoR1 and AdipoR2 in subcutaneous adpipose tissue (ST) of women with various levels of fat in their organism. A further objective of the study was to determine to what extent the stated parameters correlate with obesity as defined by BMI (body mass index) and how it can be affected by a very low calorie diet (VLCD). Patient sample:The sample of 70 women was divided into groups by BMI: patients with class 3 obesity (BMI > 40 kg.m^-2, n = 25), patients with class 1 and...

Diagnosis and treatment of chronic hepatitis B

P. Husa, S. Plíšek, J. Šperl, P. Urbánek, J. Galský, P. Hůlek, P. Kümpel, V. Němeček, M. Volfová

Vnitr Lek 2007, 53(11):1221-1230  

Chronic hepatitis B is one of the world's most common infectious diseases. In the Czech Republic it has a prevalence of 0.56%. Antiviral therapy for chronic hepatitis B demonstrably increases quality of life and where indication criteria are met and standard therapeutic procedures are followed, it is clearly cheaper than treatment for the complications of advanced cirrhosis of the liver or hepatocellular carcinoma. At the time of issuing of this recommendation, 4 medicines were classified for the treatment of chronic hepatitis B in the Czech Republic - pegylated interferon (IFN) α-2a, conventional IFN α, lamivudine (LAM) and adefovir dipivoxil...

Rituximab (MabThera®) - a new biological medicine in rheumatoid arthritis therapy

P. Němec

Vnitr Lek 2007, 53(11):1199-1210  

Rheumatoid arthritis (RA) is a serious, chronic, inflammatory disorder that damages the joints. The chronic destructive process causes pain to patients with RA and leads to the development of permanent disability. At present, great emphasis is placed on timely and effective therapy for RA, which is able to halt or slow the development of the disorder. At present we do not have any means of curing RA, the main objective for treatment is to induce remission of the disorder and prevent structural damage to the joints and the development of permanent disability. The relatively frequent failure of disease modifying medications (DMARDs) lead to efforts to...

Superior vena cava syndrome (definition, aetiology, physiology, symptoms, diagnosis and treatment)

Y. Staňková, I. Vašutová, J. Skřičková

Vnitr Lek 2007, 53(11):1211-1214  

Superior vena cava syndrome is a group of symptoms arising from reduced blood flow from the superior vena cava to the right atrium. The causes of superior vena cava syndrome can be malignant or benign. Nearly 95% of cases are, however, the result of malignant diseases. Superior vena cava syndrome is characterised by swelling of the face, neck or upper limbs with visible dilation of the veins in the neck or chest. Frequent symptoms are breathlessness and coughing. The treatment of the syndrome depends on the aetiology of the obstruction, the seriousness and prognosis of the disease. Treatment should begin as early as possible.

Endoscopic cytoscopy

Z. Beneš, O. Daum, G. Puškárová, P. Kohout, Z. Antoš, M. Černík

Vnitr Lek 2007, 53(11):1215-1219  

A number of new endoscopic methods have been developed recently, which aim to allow the most accurate possible viewing of the mucosa of the digestive tract. These procedures include endoscopic cytoscopy, which together with confocal endoscopy is a technique of so-called endoscopic microscopy. By means of enodcytoscopy it is possible to view "in vivo" the morphological details of the surface of the mucosa of the digestive tract. The mucosa must, however, be thoroughly cleaned and stained with methylene blue. The paper presents our own initial experience of this method, which may lead to faster and more accurate diagnosis of pre-tumorous or tumourous...

Monagan D. Journey into the heart

Pavel Jerie

Vnitr Lek 2007, 53(11):1231-1233  

Rybka J. Diabetes mellitus - komplikace a přidružená onemocnění

Štěpán Svačina

Vnitr Lek 2007, 53(11):1233  

Monhart V. Hypertenze a ledviny

Vladimír Tesař

Vnitr Lek 2007, 53(11):1234