Vnitr Lek 2007, 53(11):1164-1169

Utilisation of Glykogen Phosphorylase BB measurement in the diagnosis of acute coronary syndromes in the event of chest pain

B. Lačňák^1,*, D. Stejskal^1,2, L. Jedelský², M. Karpíšek³, L. Šprongl⁴

¹ Interní oddělení nemocnice Šternberk, přednosta prim. MUDr. Bořek Lačňák

² Oddělení laboratorní medicíny nemocnice Šternberk, přednosta doc. MUDr. David Stejskal, Ph.D.

³ Ústav humánní farmakologie a toxikologie Farmaceutické fakulty Veterinární a farmaceutická univerzity Brno, vedoucí Ing. Michal Karpíšek

⁴ Centrální laboratoře Šumperské nemocnice, a.s., Šumperk, přednosta Ing. Luděk Šprongl

Introduction:
Glykogen Phosphorylase BB is considered a timely and specific marker of acute coronary syndrome. A kit for measuring Glykogen Phosphorylase BB in routine diagnosis has been released recently.


Objective of the study:
To test the utilisation of Glykogen Phosphorylase BB measurement in the diagnosis of acute coronary syndrome.

Method:
70 patients with suspected acute coronary syndrome were tested. A final diagnosis of acute coronary syndrome/non-coronary difficulties was made according to ESC/ACC/AHA criteria. Measurements of troponin I, myoglobin and GPBB in venous plasma (heparin-lithium) were taken for all probands on admission and two and six hours later.

Results:
Individuals with acute coronary syndrome (n = 52) had significantly higher levels of Glykogen Phosphorylase BB on admission and 2 hours after admission (21.9 vs 6.2; 18.7 vs 5.9 μg/l; p < 0.01). Levels of Glykogen Phosphorylase BB had a greater diagnostic effectiveness for the presence of acute coronary syndrome than levels of troponin I (threshold below ROC curve 0.89 vs. 0.78; 0.87 vs. 0.67). In the first two hours after admission, only levels of Glykogen Phosphorylase BB were included as independent variables in the regression model for the incidence of acute coronary syndrome (p

Keywords: Glykogen Phosphorylase; acute coronary syndromes; non-STEMI; coronary markers

Received: March 18, 2007; Accepted: June 12, 2007; Published: November 1, 2007  Show citation