Endoskopické změny sliznice žaludku a dvanáctníku při léčbě minidávkou acetylsalicylové kyseliny a jejich prevence - editorial

J. Ehrmann, V. Procházka, M. Konečný, M. Špaček, K. Urbánek

Vnitr Lek 2007, 53(10):1024-1028  

Rituximab (antiCD20 monoklonální protilátka) a molekulárně biologická negativita po léčbě nemocných s folikulárním lymfomem - cesta k vyléčení? - editorial

M. Trněný

Vnitr Lek 2007, 53(10):1029-1030  

Plicní alveolární proteinóza - minulost a přítomnost - editorial

M. Doubková

Vnitr Lek 2007, 53(10):1031-1032  

Lékové stenty - pro všechny, pro někoho, či pro nikoho? - editorial

V. Kočka, P. Widimský

Vnitr Lek 2007, 53(10):1033-1034  

Changes in lipid metabolism in patients in the active phase of Crohn's disease

V. Hrabovský, Z. Zadák, V. Bláha, R. Hyšpler, T. Karlík

Vnitr Lek 2007, 53(10):1035-1039  

Introduction:Crohn's disease (CD) in its active period is accompanied by a decreased food intake and deterioration in water, mineral and metabolic balance. Lipid metabolism is known to be altered in many acute diseases, and hypocholesterolemia is a serious negative prognostic indicator. The causes of decreased serum cholesterol concentration are multiple. Simultaneous affection of both cholesterol synthesis and absorption has been reported in many sources. The changes in both the above processes can be quantified with the use of specific indicators of synthesis (cholesterol level) and absorption (sitosterol and campesterol levels). Objective:The...

Cortisol levels are more closely associated with depressiveness and other psychopathologies than catecholamine levels

Z. Hess, J. Podlipný, H. Rosolová, O. Topolčan, B. Petrlová

Vnitr Lek 2007, 53(10):1040-1046  

Objective:Quantification of changes in the levels of the above hormones, i.e. cortisol, adrenalin, noradrenalin and dopamine depending on the presence of depressive symptoms and other psychopathological symptoms. Sample: 259 randomly selected individuals from the population of the city of Pilsen. Method:Zung self-assessment scale and SCL-90 questionnaire were used to assess depressiveness and other psychopathologies. Serum cortisol levels were measured, as well as the levels of cortisol and catecholamine (adrenalin, noradrenalin and dopamine) in a 24-hour urine sample. The studied sample was divided, by an arbitrarily defined...

Our experience in continuous administration of insulin using infusion dispenser at a metabolic intensive care unit (MICU)

J. Charvát, S. Pálová, M. Horáčková, J. Kratochvíl, J. Masopust

Vnitr Lek 2007, 53(10):1047-1052  

Introduction:The article summarises the experience of the authors in the administration of insulin using an infusion dispenser at a metabolic intensive care unit (MICU) both to patients with decompensated diabetes mellitus and to patients admitted with a sepsis or other life-threatening condition of internal nature. Patients and results:Insulin was administered with the use of a dispenser to a total of 50 patients during 6 months of 2005. 13 of those patients showed signs of ketoacidotic or hyperosmolar coma in the course of diabetes mellitus. All of these patients were compensated within 24 hours and transferred to a standard...

Endoscopic changes in the stomach and duodenal mucosa caused by minidose acetylsalicylic acid therapy and their prevention

I. Novotný, P. Dítě, M. Kunovská, H. Münzová

Vnitr Lek 2007, 53(10):1053-1056  

Minidose acetylsalicylic acid (ASA) administration is a significant risk factor for changes in the stomach and duodenal mucosa also in persons whose anamnesis does not indicate any previous symptoms of stomach disease or any other risk factor. One month ASA minidose therapy provoked changes in the stomach and duodenal mucosa in 43.7 % of persons receiving the therapy for cardiologic or neurologic indications. The changes primarily involved erosion and were mainly located on the stomach mucosa, without signs of active bleeding. If ASA minidose therapy was administered for 1 month together with the proton pump inhibitor omeprazole, the rate of incidence...

Achieving Bcl-2/IgH negativity in peripheral blood/bone marrow after therapy implies better prognosis for patients with follicular lymphoma

D. Belada, L. Smolej, P. Štěpánková, M. Beránek, D. Dvořáková, J. Bukač, J. Malý

Vnitr Lek 2007, 53(10):1057-1063  

Bcl-2/IgH rearrangement is a characteristic molecular rearrangement in patients with follicular lymphoma (FL), yet its prognostic significance is still unclear. Objective:Evaluation of the implications of achieving Bcl-2/IgH negativity for the prognosis of FL patients. Twenty seven patients (54 %) were receiving only chemotherapy (CHT), 23 patients (46 %) were receiving chemotherapy combined with monoclonal antibody anti/CD20, rituximab (R-CHT). Results:Molecular genetic remission was achieved in 7 out of 11 patients (64 %) after R-CHT, and only in 2 out of 14 patients (14 %) after CHT - this difference was statistically...

The impact of statin therapy on bone density changes in postmenopausal women

P. Švejda, V. Soška, M. Souček

Vnitr Lek 2007, 53(10):1064-1070  

Generalised use of statins in primary and secondary prevention of ischemic heart disease has led in recent years to the discovery of a number of other "pleiotropic" effects of statins. One of them is the effect of statins on bone metabolism. The objective of the study was to monitor bone density, bone turnover markers and basic biochemical parameters in a group of postmenopausal women at regular intervals for a period of 2 years. The monitoring allowed for an assessment of the effect of statin therapy on those parameters. Statin therapy safety was also monitored. According to expectations, the group receiving active treatment recorded a decrease in...

Analysis of the effect of circadian rhythm on the heart rate turbulence in patients without evidence of organic heart disease

P. Trčka, M. Kozák, M. Sepši, L. Křivan, J. Vlašínová

Vnitr Lek 2007, 53(10):1071-1076  

Some studies have demonstrated circadian incidence of sudden cardiac death (SCD), ventricular ectopies, acute coronary syndromes and heart rate variability. One of new parameters applied in non-invasive stratification of sudden cardiac death is heart rate turbulence (HRT). Detection of circadian oscillations in HRT and optimised measurement of HRT can increase the positive predictive value of HRT as a sign of SCD risk. The set consisted of 48 patients in a sequence order aged 45 ± 12 years (of which 23 men and 25 women), indicated for Holter monitoring of ventricular ectopies who had good left ventricular function with LV EF 0.53 ± 0.11....

Pulmonary alveolar proteinosis

B. Hutyrová

Vnitr Lek 2007, 53(10):1077-1084  

Pulmonary alveolar proteinosis is a rare disease characterised by excessive accumulation of surfactant components in the alveoli and the distal airways with minimum inflammatory reaction and fibrosis of pulmonary interstitium. Three clinical forms of pulmonary alveolar proteinosis are distinguished - congenital, primary and secondary. Results of ultrastructural, biochemical and functional analyses and studies performed on genetically modified mice support the presumption that accumulation of surfactant in pulmonary alveolar proteinosis is a result of a degradation disorder and of diminished clearance of the surfactant from the alveolar space rather...

Late coronary stent thrombosis and clopidogrel

I. Varvařovský, J. Matějka, A. Herman

Vnitr Lek 2007, 53(10):1085-1091  

The existence of late coronary stent thrombosis is a topical issue in cardiology today. The synoptic article discusses current definition of the above phenomenon, its delimitation in time and actual incidence. Based on data from available observation and randomised studies, long-term safety of conventional bare metal and drug-eluting stents is evaluated, as well as the safety profile following implantation. The length of thienopyridin treatment after percutaneous coronary intervention (PCI) varies according to the type of stent used. While a conventional bare metal stent (BMS) implant provides long-term safety with one month treatment, the implantation...

The MIAC (malnutrition, inflammation, atherosclerosis, calcification) syndrome

E. Mistrík, V. Bláha, S. Dusilová Sulková, L. Sobotka

Vnitr Lek 2007, 53(10):1092-1099  

The number of patients with chronic renal failure is on the rise; these patients have a 10 to 20 times higher risk of development and progression of cardiovascular diseases. Higher cardiovascular risk in such patients cannot be satisfactorily explained by traditional risk factors defined in the Framingham study. On the contrary, a concept of reverse epidemiology has been brought forward, designating a situation in which the incidence of obesity and hyperlipoproteinemia is associated with a higher survival rate of the patients concerned. Higher risk is today explained by the "MIAC (malnutrition, inflammation, atherosclerosis, calcification) syndrome",...

Pseudomembranous colitis

D. Bergmann, J. Koten, Z. Beneš, P. Kohout, A. Chlumská

Vnitr Lek 2007, 53(10):1100-1107  

For some thirty years it has been known that pathologic proliferation of toxigenic Clostridium difficile may lead to inflammation of colonic mucosa which, in its fully developed form, manifests as pseudomembranous colitis. CDAD ( Clostridium difficile - Associated Disease or Diarrhoea) is the term which is generally and quite aptly used for the disease in literature on the subject. In most cases, the disease develops after the administration of broad-spectrum antibiotics, yet there are also other important pathogenetic factors involved which should not be ignored. The disease has grown in significance over...

Incretin strategy in the treatment of type 2 diabetes mellitus - the DPP-IV inhibitor sitagliptin

J. Perušičová

Vnitr Lek 2007, 53(10):1109-1113  

Sitagliptin, distributed under the brand name of Januvia, has been the first and so far the only dipeptidyl peptidase IV (DPP-IV) inhibitor introduced in clinical practice. The results of published clinical studies clearly demonstrate its effectiveness and safety as an oral antidiabetic. Apart from increasing the insulin level, Sitagliptin reduces the level of glucagon. The principal advantages of Sitagliptin from the clinical point of view are: a) the ability to reduce both fasting and non-fasting glycaemia and improve the HbA1c values, b) the fact that it does not provoke weight increase, c) the fact that the risk of hypoglycaemia is significantly...

The benefit from ibandronate in the treatment of postmenopausal osteoporosis

Z. Málek

Vnitr Lek 2007, 53(10):1114-1118  

Apart from other factors, the treatment of osteoporosis is limited by a narrow range of applicable drugs. Ibandronate, forming part of the aminobisphosphonate group, which was launched in clinical practice in 2005, has extended the range of treatment options. It allows for intermittent dosage in 1-month (oral form) or 3-month (intravenous form) intervals, whilst the high efficiency of treatment and good safety profile are preserved. Intermittent dosage significantly improves the adherence of patients to treatment, which has, apart from other advantages, a positive effect on cost efficiency of treatment. In addition, oscillation in bone remodelation...

Chronic benign exsudative pericarditis - a case of familiar incidence

E. Sovová, D. Marek, A. Bulava, A. Šantavá, J. Klein, J. Lukl

Vnitr Lek 2007, 53(10):1119-1122  

Pericarditis is a common disease caused by a number of factors. Chronic pericarditis is defined as the presence of pericardial effusion for more than 3 or 6 months. The case study reports a case of familiar incidence of chronic exsudative pericarditis in a young woman, her sister and her mother, with an analysis of diagnostic and therapeutic options. According to available literature, this is the second case described of such form of familiar incidence.

Škubla P. Veľký atlas húb

Andrej Dukát

Vnitr Lek 2007, 53(10):1127  

Kutnohorská J. Etika ve zdravotnictví

Alena Štětková

Vnitr Lek 2007, 53(10):1127-1128  

Grofová Z. Nutriční podpora. Praktický rádce pro sestry

Alena Mottlová

Vnitr Lek 2007, 53(10):1128  

Krajíček M, Peregrin JH, Roček M, Šebesta P et al. Chirurgická a intervenční léčba cévních onemocnění

Ivo Hofírek

Vnitr Lek 2007, 53(10):1129  

Prof. MUDr. Petr Broulík, DrSc., sedmdesátníkem

Štěpán Svačina, Petr Sucharda

Vnitr Lek 2007, 53(10):1130  

Erratum et corrigendum

Vnitr Lek 2007, 53(10):1122  

Výsledky studie ADVANCE

P. Havránek

Vnitr Lek 2007, 53(10):1123-1126