Katetrizační ablace - metoda 1. volby v léčbě flutteru síní - editorial

J. Kautzner

Vnitr Lek 2006, 52(2):107-109  

Význam transezofageálnej echokardiografie v detekcii kardiogénnej a aortálnej embolizácie při ložiskovej ischémii mozgu a tranzitórnych ischemických atakách - editorial

D. Marek

Vnitr Lek 2006, 52(2):110-112  

Klinické příznaky, diagnostika a terapie ortostatické intolerance - editorial

B. Semrád

Vnitr Lek 2006, 52(2):113-114  

Komplikace v průběhu léčby mnohočetného myelomu - editorial

I. Špička

Vnitr Lek 2006, 52(2):115  

Mutational analysis of LQT genes in individuals with drug induced QT interval prolongation

T. Novotný, J. Kadlecová, I. Papoušek, K. Chroust, A. Bittnerová, A. Floriánová, E. Češková, M. Weislamplová, V. Pálenský, M. Šišáková, O. Toman, R. Gaillyová, J. Špinar

Vnitr Lek 2006, 52(2):116-118  

Background:In a long list of non-cardiovascular drugs a risk of QT interval prolongation and thus an increased risk of malignant arrhythmias has been described. The precise mechanism remains unclear. Many of these drugs are potent blockers of cardiac ion channels. Thus, prolongation of repolarization could be caused by latent ion channel genes mutations which are revealed under stress conditions. Group of patients and methods:Patients were recruited in screening of antipsychotic drugs with proarrhythmic potential, another sporadic cases were reffered from regional hospitals. In 13 individuals pathologic values of corrected...

The meaning of the combination of fibrinogen, micro/macroalbuminuria and atheromatosis in the carotic bloodstream for the evaluation of the abnormal finding of the stress myocardial SPECT in the asymptomatic 2nd type diabetic patients

V. Zamrazil jr, S. Pálová, D. Holá

Vnitr Lek 2006, 52(2):119-123  

Objectives:Stress perfusion myocardial scintigraphy (SPECT) is useful in silent ischemia detection in the group of the asymptomatic type 2. diabetic patients. In our paper we present the combinations of the parameters predictive for stress myocardial SPECT result. Methods:We selected parameters (fibrinogen, micro/macroalbuminuria, ateroma in carotid artery bed) that were significantly associated with stress myocardial SPECT result. We analyzed the combinations of these parameters change and evaluated their significance for stress myocardial SPECT result prediction. Results:We evaluated 121 type 2. diabetic patients...

Idiopathic premature ventricular complexes - catheter ablation as a therapeutic alternative

J. Chovančík, M. Fiala, H. Szymeczek, R. Neuwirth, R. Nevřalová, I. Nykl, M. Branny

Vnitr Lek 2006, 52(2):124-131  

Frequent isolated ventricular premature complexes (VPCs) in patients without major structural heart disease are generally associated with benign prognosis, however can lead to serious symptoms and also to the development of left ventricular dysfunction. Purpose of this study is to present mapping findings and immediate results of catheter ablation of frequent idiopathic VPCs, and evaluation of long-term clinical outcome and the role of catheter ablation in clinical practice. Methods:Twenty-seven patients, aged 48 ± 14 years without major structural heart disease, presenting with frequent VPCs, were investigated electrophysiologically...

Can we cure atrial flutter with radiofrequency ablation in an hour?

Z. Stárek, L. Zaoral, P. Leinveber, L. Haman, Z. Csanádi, D. Heřman

Vnitr Lek 2006, 52(2):132-136  

Background:Radiofrequency ablation of common atrial flutter requires the creation of a complete transmural ablation line across cavotricuspid region to achieve bidirectional conduction block. Irrigated tip catheters facilitate rapid achievement of this block by creation larger and deeper lesions. The EASTHER registry was organized to collect data about the efficacy of the procedure in small and middle volume centres in Central and Eastern Europe, all using THERMOCOOL® catheter technology. Methods:Easther is a prospective registry (April 2002-February 2003). 133 consecutive patients (81.1 % male, age 59.0 ± 10.4...

Autoimmune thyropathies in diabetics

Z. Schroner, I. Lazúrová, J. Petrovičová

Vnitr Lek 2006, 52(2):137-143  

Autoimmune thyropathies are frequent in patients with type 1 diabetes mellitus. Some recently published papers confirm similarly high prevalence of autoimmune thyropathies also in patients with type 2 diabetes mellitus. Chronic autoimmune thyroiditis is the most frequent form of autoimmune thyropathies. Authors examined 79 accidentally selected diabetics (38 women and 41 men, x = 55.4 ± 2.8). Diabetic patients were divided into three groups. 20 patients with type 1 diabetes mellitus - classical form were the first group, 12 patients with LADA were the second group and 47 patients with type 2 diabetes mellitus constituted the third group. Authors...

The role of transesophageal echocardiopgraphy in detection of cardiogenic and aortic sources of embolism in stroke and transient ischaemic attacks

J. Dúbrava, R. Garay

Vnitr Lek 2006, 52(2):144-151  

Objectives:To prospectively investigate the prevalence of definite and potential sources of cardiogenic embolism and embolism from ascending aorta and aortic arch in patients with a cryptogenic stroke or transient ischaemic attack (TIA). Material/methods:The study group consisted of 218 consecutive patients (146 males, mean age 59.4 ± 11.5, range 38-83 years) without significant stenoses of carotic and vertebral arteries. All patients underwent biplane/multiplane transesophageal echocardiography (TEE). 77.5 % of patients suffered a stroke and 22.5 % had a TIA. Sinus rhythm was in 74.8 % of the patients, atrial fibrillation...

The meaning of viral kinetics in the beginning of the pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C

P. Husa, P. Šlesinger, H. Štroblová, A. Svobodník

Vnitr Lek 2006, 52(2):153-159  

Pegylated interferon α (PEG-IFN) and ribavirin combination therapy is the contemporary standard therapy of the patients chronically infected with hepatitis C virus (HCV). Objective of the study:The study is monitoring the changes in viremy through the changes of HCV RNA in serum before and during antiviral therapy and it attempts to find a relationship between the viral kinetics in the beginning of the therapy and the sustained virologic response. Set of the patients and the methodics:The study involved 133 patients with chronic infection with HCV, of the average age of 38 years (ranged 18-68 years). 86 of them were...

Standardní diagnostický a terapeutický postup u genetické (hereditární) hemochromatózy. Doporučený postup České hepatologické společnosti České lékařské společnosti J. E. Purkyně

J. Horák

Vnitr Lek 2006, 52(2):173-175  

Medical device Task Force Monitor in diagnostics of syncope by means of head-up tilt table testing

J. Siegelová, B. Fišer

Vnitr Lek 2006, 52(2):160-166  

Head-up tilt table testing is used for diagnostics of vasovagal syncope. Beat-to-beat blood pressure recording and ECG monitoring is not sufficient for clarification of the syncope mechanisms in individual patients, however. That is why a Task Force Monitor was developed in Graz, Austria. In addition this device enables stroke volume recording by impedance method. Other advantages are calculations of cardiac output, beat-to-beat total peripheral resistance, heart rate variability and baroreflex sensitivity as well as activity of sympathicus and parasympathicus assessment. These methods enable detailed hemodynamic analysis during the whole head-up...

The role of STAT proteins in the regulation of the response to the interferone α therapy in chronic hepatitis C

J. Ehrmann jr., K. Aiglová, J. Ehrmann, J. Palas, P. Kümpel

Vnitr Lek 2006, 52(2):167-172  

The currently used standard treatment for chronic hepatitis C using a dual combination of IFNα/RBV is only successful in 50 % cases. With the exception of some clinical and biochemical factors, degree of inflammation (grading) and degree of fibrosis (staging), there are no other known markers which may serve as valid predictors of response to therapy. Interference of hepatitis C virus (HCV) with signaling pathways modulated by JAK-STAT, ERK 1/2, NFκB and MAP proteins is one mechanism which may influence the interaction between HCV and IFNα. These proteins regulate different cell processes such as activation of cytokines, activation...

Osteonecrosis of the jaw in the course of multiple myeloma treatment and bisphosphonate administration

Z. Adam, M. Kozumplíková, L. Pour, M. Machálka

Vnitr Lek 2006, 52(2):176-180  

The osteonecrosis of jaws is a phenomena newly described in the connection with bisphosphonate therapy. We describe a case of a 41 years old man with multiple myeloma, who developed the osteonecrosis of jaw in the course of antimyeloma therapy. The men had tooth pain from the beginning of the chemotherapy, but the extraction was performed till one month before high dose chemotherapy with peripheral stem cell transplantations, when the conservative therapy was find unsatisfactory. Bisphosphonate were administered from the beginning of the chemotherapy, the bisphosphonate therapy was started with clodronate and later changed to zoledronate. One year...

Tachycardia-induced cardiomypathy: less usual causes, less usual treatment: 3 case-reports

B. Holek, M. Fiala, J. Chovančík, M. Branny

Vnitr Lek 2006, 52(2):181-185  

Tachycardia-induced cardiomypathy is a potentially reversible form of left ventricular dysfunction and heart failure that is often neglected in clinical practice. Three case-reports of tachycardia-induced cardiomyopathy associated with three different tachyarrhythmias, cured by catheter ablation, are presented. All cases were characterized by specific clinical conditions. Potential consequences of inadequate clinical analysis and treatment are discussed.

Malina L. Antihistaminika a antimalarika v dermatologii. Praha: Maxdorf 2005. 82 stran. ISBN 80-7345-065-8

Vladimír Vašků

Vnitr Lek 2006, 52(2):189  

Malina L. Fotodermatózy. 2. rozšířené vydání. Praha: Maxdorf 2005. 206 stran. ISBN 80-7345-039-9

Vladimír Vašků

Vnitr Lek 2006, 52(2):189-190  

Balíková M. Forenzní a klinická toxikologie. Laboratorní toxikologická vyšetření. Praha: Galén 2004. 140 stran. ISBN 80-7262-284-6

Igor Bátora

Vnitr Lek 2006, 52(2):190-191  

Marek J (editor). Endokrinní hypertenze. Praha: Galén 2004. 208 stran, ISBN 80-7262-270-6

Věra Olšovská

Vnitr Lek 2006, 52(2):191  

Šlampa P, Soumarová R, Kocáková I et al. Konkomitantní chemoradioterapie solidních nádorů. Praha: Galén 2005. 167 stran. ISBN 80-7262-276-5

Jiří Petera

Vnitr Lek 2006, 52(2):191-192  

Prokeš J et al. Základy toxikologie. Obecná toxikologie a ekotoxikologie. Praha: Galén a Karolinum 2005. 248 stran. ISBN 80-7262-301-X (Galén), 80-246-1086-X (Karolinum)

Igor Bátora

Vnitr Lek 2006, 52(2):192-193  

Boehmeke T, Doliva R. Pocket Atlas of Echokardiography. Stuttgart: Thieme Stuttgart 2006. 225 stran. ISBN 3-13-14241-0

Vít Mařatka

Vnitr Lek 2006, 52(2):193-194  

Svačina Š (ed) et al. Trendy soudobé diabetologie. Praha: Galén 2005. Vol. 10. 225 stran. ISBN 80-7262-359-1

Silvie Lacigová

Vnitr Lek 2006, 52(2):194  

Tošenovský P, Edmonds ME et al. Moderní léčba syndromu diabetické nohy. Praha: Galén 2004. 207 stran. ISBN 80-7262-261-7

Silvie Lacigová

Vnitr Lek 2006, 52(2):196  

Jubileum prof. MUDr. Vlastimila Ščudly, CSc.

Pavel Horák

Vnitr Lek 2006, 52(2):186-187  

Prim. MUDr. Jaroslav Přehnal, CSc., zemřel

Vnitr Lek 2006, 52(2):187-188