[The hemophagocytic syndrome].

M Bláha

Vnitr Lek 2003, 49(3):163-164

[Editorial on the article by O. Valocik et al: "Effect of ACE gene polymorphism on left ventricular function in type 2 diabetes"].

A Vasků

Vnitr Lek 2003, 49(3):164-165

[The stomach and bone metabolism].

V Palicka

Vnitr Lek 2003, 49(3):166-167

[Right-sided infectious endocarditis--an uncommon but increasing problem].

J Schildberger

Vnitr Lek 2003, 49(3):168-170

[Dementia in the Czech Republic--views of an internist and geriatrician].

P Weber

Vnitr Lek 2003, 49(3):170-171

[Comment on the article by S. Krajcík: What are the possibilities of preventing dementia?].

R Jirák

Vnitr Lek 2003, 49(3):171-172

[Editorial on the article by H. Svacinová et al: "Effect of walking exercise on aerobic capacity and blood lipids in type 2 diabetes].

A Smahelová

Vnitr Lek 2003, 49(3):172-173

[Long-term results of the UHKT-911 study of adult patients under 65 years of age with de novo acute myeloid leukemias without favorable karyotypes].

P Lemez, A Vítek, K Michalová, Z Zemanová, M Lukásová

Vnitr Lek 2003, 49(3):174-180

Between February 1991 and April 1994 induction chemotherapy of 32 adult consecutive patients under 65 years with de novo acute myeloid leukemias (AML) was started in the study UHKT-911. They were 19 women and 13 men, aged 18-63 (median 44) years. Their AML were classified according to the FAB classification: 3 M0, 3 M1, 9 M2, 14 M4, 3 M5. Induction chemotherapy consisted of 1-2 cycles with 3-4 doses of daunorubicin (DNR) 45 mg/m2/d i.v. and 14 doses of cytosine arabinoside (Ara-C) 200 mg/m2 per 3-h infusion every 12 hours. After the treatment patients, not being in complete remission, got the HD cycle with 10 high-doses of Ara-C 2000 mg/m2 per 3-h...

[Effect of ACE gene polymorphism on left ventricular function in patients with type 2 diabetes].

G Valocik, I Rosochová, L Kovács

Vnitr Lek 2003, 49(3):181-184

The authors evaluated the influence of the ACE gene polymorphism on left ventricular function in patients with diabetes type 2. In a group of 23 patients left ventricular mass, global and regional systolic function of the left ventricle as well as diastolic function was assessed from transmitral flow using two-dimensional echocardiography. In a subgroup of patients with DD (n = 7) and ID genotype (n = 16), no significant differences were found in age (p = 0.19), duration of diabetes (p = 0.46), level of HbA1c (p = 0.10), cholesterol level (p = 0.18), quantitative proteinuria (p = 0.39), systolic and diastolic blood pressure (p = 0.25, p = 0.40). No...

[Importance of measurement of carotid artery distensibility].

J Chlumský, J Charvát

Vnitr Lek 2003, 49(3):185-188

Affections of the structure of the major blood vessels can be assessed non-invasively by ultrasound. The authors assessed the thickness of the intima-media (IMT) and distensibility (D) of the carotid arteries in patients with ischaemic heart disease (IHD) and a cerebrovascular attack (CVA). Duplex sonography was used in 234 patients (145 patients with IHD and 89 patients with CVA) incl. assessment of IMT and D. 59 patients had type 2 diabetes and 64 had atrial fibrillations. D was evaluated according to Raneman's formula (mm/100 mm Hg). Diabetic subjects had a poorer D in the group with IHD (0.16 vs. 0.20, p < 0.05) as well as in the CVA group (0.14...

[Myelotoxicity after systemic radionuclide therapy of painful bone metastases with 153Samarium-EDTMP ].

J Dolezal, J Vizďa, E Cermáková

Vnitr Lek 2003, 49(3):189-193

AIM: The breast cancer and the prostate cancer are considered as the most frequently occurred metastatic tumors in bones. The bone pain appears in majority of patients with metastases. One possibility how to reduce or to remove this pain is the administration of the radiotherapy to the place of metastases. The present medicine disposes of two ways how to administer radiotherapy in the place of metastases: externally irradiation (loco-regional or half-body) or intravenous administration of bone-seeking therapeutic radiopharmaceuticals.MATERIAL AND METHOD: We introduced intravenous administration of 153Samarium-EDTMP in 57 patients (30 prostate...

[Bone changes in patients after partial gastric resection].

J Payer, E Stenová, Z Killinger, M Huorka, H Kratochvíľová, P Ondrejka

Vnitr Lek 2003, 49(3):194-199

Metabolic diseases of the bones may be a serious complication of gastrectomy. The pathogenesis of osseous changes is multifactorial. The most important causes include a reduced intake of dairy products, their fastened passage through the stomach and reduced calcium and vitamin D absorption. The objective of the work was to assess bone changes in patients after partial gastrectomy. From a total number of 261 patients with a minimal 10-year history of gastrectomy, in the investigation 31 patients were included (18 men and 13 women) who met the required criteria. The results were compared with a control group of 18 men and 13 women of equal age. The authors...

[Pitfalls in the diagnosis of carcinoids in patients treated with aminosalicylates].

M Dastych, M Dastych, V Zboril, M Senkyrík, K Starý, J Cáslavský, J Chmelík

Vnitr Lek 2003, 49(3):200-204

INTRODUCTION: Carcinoid is one of the most common endocrine active tumours of the gastrointestinal tract. 90% of all carcinoids originate from enterochromaffine cells in the GIT. In the literature the relationship of carcinoid of the bowel and IBD is mentioned, in particular Crohn's disease. The screening test used under our conditions is assessment of the excretion of the metabolite serotonin, 5-hydroxyindole acetic acid (HIAA) in urine. The authors wish to draw attention to falsely positive results of 5-HIAA in urine by the HPLC method in patients with CD treated with aminosalicylates (ASA).METHODS: In order to rule out carcinoid in chronically...

[The effect of walking exercise on aerobic capacity and serum lipids in type 2 diabetics].

H Svacinová, J Olsovský, V Zácková, J Jancík, Z Placheta, J Siegelová

Vnitr Lek 2003, 49(3):205-209

Regular physical activity can have a favourable impact on other risk factors of ischaemic heart disease (IHD) and associated diabetes (DM), such as obesity, hypertension, dyslipidaemia, insulin resistance and others. This important part of treatment of diabetes is frequently difficult to implement because of the lack of willingness ("adherence") of type 2 diabetics to practice regular exercise, and unequivocal data are lacking on the intensity of exercise which will influence effectively these risk factors and be at the same time safe, readily available and psychologically acceptable. The objective of the work was to find out whether walking, i.e....

[Hemophagocytic syndrome (case report and literature review)].

A Oborilová, J Mayer, P Pavlík, A Buliková, J Vorlícek

Vnitr Lek 2003, 49(3):210-216

The haemophagocytic syndrome (HPS) is clinically characterized by fever, pancytopenia and hepatosplenomegaly. Usually it takes an acute course with a high mortality. The pathogenetic basis is inadequate activation of the immune system--in particular Th1-lymphocytes with subsequent overproduction of cytokines and extreme activation of macrophages with haemophagocytosis. The activated cells infiltrate organs, cause tissue damage and clinical manifestations of the syndrome. From the etiological aspect two forms exist: primary (familial) with autosomal recessive inheritance and the secondary form which forms a heterogeneous sub-group, caused as a rule...

[Atherosclerotic nephropathy in renal artery stenosis--from randomized studies to individualized therapy].

A Oksa, R Dzúrik, M Demes

Vnitr Lek 2003, 49(3):217-221

Randomized trials in hypertensive patients with atherosclerotic renal artery stenosis (ARAS) mostly did not reveal any significant difference between antihypertensive treatment and revascularization (by angioplasty or bypass surgery) in their effects on blood pressure or glomerular filtration rate. This unexpected conclusion reflects a fact that in addition to potentially reversible ischemia, some other factors which are not eliminated by technically successful revascularization take part in the decrease of renal function in ARAS, including cholesterol microemboli from atherosclerotic plaques, secondary focal segmental glomerulosclerosis and hypertensive...

[Plasminogen activator inhibitor-1 (PAI-1), ischemic heart disease and diabetes mellitus].

P Olexa, M Olexová

Vnitr Lek 2003, 49(3):222-226

The classic risk factors can only in part explain the increased incidence and extent of coronary artery disease. Plasminogen activator inhibitor type-1 (PAI-1), the main human regulator of endogenous fibrinolysis, is considered to be an important cardiovascular risk factor. The article discuss the current knowledge of the PAI-1 importance and role in the in the pathogenesis of atherosclerosis and mechanisms of its synthesis predominantly in patients with coronary artery disease associated with diabetes mellitus type 2. It explains contributions of PAI-1 to the pathophysiologic links between diabetes mellitus and cardiovascular diseases and shows current...

[Specific features of hematopoiesis and hemostasis in advanced age].

H Kubesová, M Penka

Vnitr Lek 2003, 49(3):227-233

The ageing process affects also haematopoiesis and haemostasis and these changes can have a far reaching effect on other organ systems and their function. The authors decided therefore to present a review on involutional changes on the formation and function of blood elements and the system of blood clotting. The review is divided into description of changes in the bone marrow and explanation of hitherto known facts on the pathophysiological background of these changes. Furthermore the authors deal with changes in the peripheral blood stream and their mutual relations with administered drugs, diseases under way, reactions to external stimuli such as...

[What are the possibilities of preventing dementia?].

S Krajcík

Vnitr Lek 2003, 49(3):234-240

Population ageing makes issue of dementia prevention very important. Measures used in prevention of other diseases are also effective in prevention of dementia. Incidence of vascular dementia is decreased by effective treatment of hypertension, diabetes and anticoagulatory treatment in patients with atrial fibrillation. Nonsteroidal antiinflammatory drugs and statins reduce incidence of Alzheimer's disease.

Protracted infection of pacemaker leads with development of large vegetations: three years follow up. Case report.

J Krupicka, M Herold, V Rychterová, Z Straka, H Línková

Vnitr Lek 2003, 49(3):241-243

A case history of a patient with permanent pacemaker reports inaccurate diagnosis of inflammation at the site of operation wound and a protracted infection of pacemaker leads. Inadequate therapy led to protracted inflammation with the leads fixed in the superior vena cava and the development of large vegetations in the right heart. Finally, the condition was resolved by surgical explantation and long-term antibiotic therapy. This case history describes infectious complications related to the implantation of a permanent pacemaker and the role of echocardiography in diagnosis of vegetations and points out the surgical treatment as a method of choice.

[Idiopathic aneurysm of the pulmonary artery].

F Holm, T Palecek, A Linhart, V Reznícek, M Aschermann

Vnitr Lek 2003, 49(3):244-247

Aneurysm of pulmonary artery (PAA) is relatively rare clinical finding and appears mostly in association with significant cardiovascular or pulmonary abnormalities and is frequently caused by pulmonary hypertension. Its diagnosis is not difficult. However, guidelines for the treatment were not yet established. Patients with PAA are at risk for sudden death by a rupture of aneurysm. Therefore, surgical correction (graft replacement) is the method of choice. Nevertheless, it seems that certain group of patients with asymptomatic idiopathic aneurysm of pulmonary artery without presence of any serious cardiovascular or pulmonary abnormality can profit...