Vnitr Lek 2003, 49(3):222-226

[Plasminogen activator inhibitor-1 (PAI-1), ischemic heart disease and diabetes mellitus].

P Olexa, M Olexová
IV. interná klinika Lekárskej fakulty UPJS a Fakultnej nemocnice L. Pasteura, Kosice, Slovenská republika.

The classic risk factors can only in part explain the increased incidence and extent of coronary artery disease. Plasminogen activator inhibitor type-1 (PAI-1), the main human regulator of endogenous fibrinolysis, is considered to be an important cardiovascular risk factor. The article discuss the current knowledge of the PAI-1 importance and role in the in the pathogenesis of atherosclerosis and mechanisms of its synthesis predominantly in patients with coronary artery disease associated with diabetes mellitus type 2. It explains contributions of PAI-1 to the pathophysiologic links between diabetes mellitus and cardiovascular diseases and shows current therapeutic interventions normalising PAI-1 activity, their beneficial effect on prognosis and course of coronary artery disease.

Keywords: Biomarkers, analysis, ; Coronary Artery Disease, complications, ; Coronary Disease, complications, ; Diabetes Mellitus, Type 2, complications, ; Humans; Plasminogen Activator Inhibitor 1, analysis, ; Renin-Angiotensin System, physiology, ; Risk Factors

Published: March 1, 2003  Show citation

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Olexa P, Olexová M. [Plasminogen activator inhibitor-1 (PAI-1), ischemic heart disease and diabetes mellitus]. Vnitr Lek. 2003;49(3):222-226.
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