[Intravascular ultrasonography in the year 2000].

M Aschermann

Vnitr Lek 2000, 46(8):437-438

[Haematopoietic stem cell mobilization in patients with multiple myeloma--comparison of 3 variations of the stimulating regime].

M Krejcí, R Hájek, Z Korístek, A Krivanová, M Navrátil, Z Adam

Vnitr Lek 2000, 46(8):439-443

In the literature various regimes are described for successful collection of haematopoietic stem cells in patients with multiple myeloma. Most frequently cyclophosphamide is used, 5 g/m2 combined with different doses of haematopoietic growth factors. In our group the yields and tolerance of three stimulating regimes are compared: 1. cyclophosphamide 5 g/m2 and filgrastim (G-CSF) 5 micrograms/kg 2. cyclophosphamide 5 mg/m2 and filgrastim 10 micrograms/kg 3. cyclophosphamide 5 g/m2 and figrastim 5 micrograms/kg along with erythropoitin 50 IU/kg. Cyclophsphamide is administered always on the first day and the haematopoietic growth factors then from the...

[Effect of antioxidant therapy on indicators of free radical activity in workers at risk of lead exposure].

V Machartová, J Racek, J Kohout, V Senft, L Trefil

Vnitr Lek 2000, 46(8):444-446

The authors administered to 36 workers exposed to lead, for four weeks the preparation Prolong which contains vitamin C, vitamin E, beta-carotene, selenium, zinc and chromium and investigated the effect on indicators of free radicals. A statistically significant increase of the following occurred: superoxide dismutase (p < 0.001), glutathione peroxidase (p < 0.01), an increase of the total antioxidant capacity (p < 0.01) and an increase of uricaemia (p < 0.05). Based on these results the authors consider supplementation with antioxidants indicated in workers exposed to lead.

[Can we determine which coronary artery is affected by the localization of ST depression? Comparison of ergometric and coronarographic results].

R Panovský, J Meluzín, E Petrikovits, L Groch

Vnitr Lek 2000, 46(8):447-451

The authors evaluated retrospectively 206 patients with ischaemic heart disease. These patients were subjected to an ergometric loading test on a bicycle ergometer followed by angiography of the coronary arteries. With regard to the site of the ST depressions during the loading test the patients were divided into 7 groups which were further subdivided according to the coronographic finding. The authors investigated the hypothesis that patients with depressions of the ST segment above the anterior wall suffer from an affection of the ramus interventricularis anterior, patients with depressions of ST above the lateral wall from affection of the ramus...

[Early rehospitalization in cardiovascular diseases].

V Spisák, L Djablíková

Vnitr Lek 2000, 46(8):452-455

The authors investigated perspectively during 1998 the frequency of early rehospitalizations (within 30 days after discharge) focused on cardiovascular diseases. From a total number of hospitalized patients (2349) early rehospitalized patients accounted for 91% (214 rehospitalizations). Rehospitalizations after cardiac attacks accounted for 45.4% rehospitalizations and for 4.1% of all hospitalized patients. The largest ratio of rehospitalizations on account of cardiovascular diseases were patients with heart failure (39.1%), with cardiac arrhythmias (22.6%) and unstable angina pectoris (21.6%). In relation to the number of total hospital admissions...

[Pedal bypass in the treatment of critical ischemia in the diabetic foot].

P Tosenovský, L Janousek, M Adamec, A Jirkovská

Vnitr Lek 2000, 46(8):456-459

A formerly established theory on obliteration of diabetic foot arteries was dismissed. In the last decade, diabetic foot revascularization using so called very distal bypass has became a routine procedure. The reconstructions are undertaken in patients with chronic critical limb ischemia. This paper presents our initial experience with this, not yet widely used, operative technique in 16 patients who had a total of 14 pedal bypass procedures performed. The parameters we monitored included the 3-, 6-, and 12-month patency rates, defect healing, and limb salvage rates. The primary and secondary patency rates were 64.3% and 78.6% at 3 months; 55.5% and...

[Changes in bone mineral density in Th12 to L5 vertebrae in female patients with osteoporosis].

J Wendlová

Vnitr Lek 2000, 46(8):460-464

UNLABELLED: The authors examined 47 female patients, age 50-60 years, with primary and secondary osteopenia and osteoporosis. In each patients they assessed the bone mineral density (BMD) of the cortical and trabecular bone of vertebrae Th12 to L5 by quantitative computer tonmography (QTC). They did not include in the group patients with deformities of the vertebrae grade one, two and three. These deformities were assessed from a lateral X-ray of the thoracic and lumbar spine.OBJECTIVE: To evaluate the importance of assessed BMD values of vertebrae from the biomechanical aspect.STATISTICAL ANALYSIS: Individual groups of assessment of BMD in...

[Monitoring minimal residual disease in pediatric patients with acute lymphoblastic leukemia].

J Zuna, O Hrusák, M Kalinová, K Muzíková, T Zörnerová, J Starý, J Trka

Vnitr Lek 2000, 46(8):465-469

The level of minimal residual disease is an important prognostic factor in childhood acute lymphoblastic leukaemia. The end of induction therapy is the most significant time-point for prediction of treatment outcome. Within a pilot study covered by the Paediatric Haematology Working Group in the Czech Republic 51 childhood patients were analysed at diagnosis of acute lymphoblastic leukaemia and at the end of induction using method based on detection of clonal rearrangements of immuno-receptor genes. The majority of tested patients (32/51, 63%) had a low or non-detectable levels of residual disease, a group of patients with the highest levels and thus...

[Intravascular ultrasound in cardiology].

P Cervinka, P J De Feyter, M Costa, M Sabaté, J M Ligthart, J Šťásek, P Serrano, G van Langenhove

Vnitr Lek 2000, 46(8):470-475

Intravascular ultrasound (IVUS) is a clinically useful tool that provides cross-sectional images of the coronary arterial lumen and wall. Diagnostic applications of IVUS include the evaluation of ambiguous lesions on angiography particularly at the bifurcations. IVUS is also useful in the assessment of coronary vasculopathy in cardiac transplant patients or it can help to diagnose abnormalities such as syndrome X or coronary artery spasm. IVUS can optimize the performing of percutaneous coronary interventions, especially stent implantation. It represents as well an optimal tool for assessing regression of atherosclerosis. Three-dimensional reconstruction,...

[Triacylglycerol as a risk factor in early ischemic heart disease].

V Soska

Vnitr Lek 2000, 46(8):476-479

Triacyglycerol levels above 2.0 mmol/l are according to contemporary findings an independent risk factor for the development of ischaemic heart disease. The triacylglycerol concentration of plasma provides information on the amount of lipoproteins, which carry also a major amount of cholesterol and which can also accelerate the process of atherosclerosis. Hypertriglyceridaemia as an independent risk factor was confirmed in particular in large epidemiological studies--the Framingham and Münster study. An increased triacyglycerol concentration implies obviously a greater risk for women than for men. From published results of intervention studies ensues...

[Intracoronary ultrasound: the "platinum standard" in evaluating the morphology of coronary stenoses. Does it have a role in clinical practice?].

J Veselka, M Mates

Vnitr Lek 2000, 46(8):480-483

The authors present the case of a 45-year-old man with a history of myocardial infarction of the anterior wall and unstable angina pectoris where they detected a critical stenosis of the proximal segment of the ramus, interverticularis anterior by intracoronary ultrasound examination. The subsequent coronary angioplasty with implantation of a stent was also implemented under ultrasound control. The authors discuss the contemporary position of intravascular ultrasound in coronary interventions in particular with regard to the development of restenosis.