Vnitr Lek 2000, 46(8):465-469
[Monitoring minimal residual disease in pediatric patients with acute lymphoblastic leukemia].
- Pro Pracovní skupinu dĕtské hematologie v CR CLIP-Childhood Leukaemia Investigation Prague.
The level of minimal residual disease is an important prognostic factor in childhood acute lymphoblastic leukaemia. The end of induction therapy is the most significant time-point for prediction of treatment outcome. Within a pilot study covered by the Paediatric Haematology Working Group in the Czech Republic 51 childhood patients were analysed at diagnosis of acute lymphoblastic leukaemia and at the end of induction using method based on detection of clonal rearrangements of immuno-receptor genes. The majority of tested patients (32/51, 63%) had a low or non-detectable levels of residual disease, a group of patients with the highest levels and thus the highest risk of relapse included 10% of patients (5/51). Within each of three risk groups one patient has relapsed so far. Therefore, the relapse rate in particular subgroups is 3% (1/32), 7% (1/14) and 20% (1/5) to date, respectively. The results are compared with these published by the BFM group (van Dongen et al., Lancet 1998). The pilot phase of a new BFM treatment protocols includes examination of residual disease for stratification of patients into the different risk groups.
Keywords: Child; Complementarity Determining Regions; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Humans; Immunoglobulin Heavy Chains, genetics, ; Neoplasm, Residual; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma, diagnosis, ; Prognosis; Recurrence
Published: August 1, 2000 Show citation