Vnitřní lékařství, 1999 (vol. 45), issue 6
[Importance of determining the propidium-iodide index of plasmacytes in multiple myeloma. I. Relation to selected laboratory indicators of the disease].
V Scudla, M Ordeltová, A Spidlová, J Bacovský, J Kurasová, M Vránová
Vnitr Lek 1999, 45(6):331-335
In a group of 85 patients with multiple myeloma (MM) incl. 50 patients examined at the time when the diagnosis was established the relationship of the values of the propidium-iodide index (PI index) of myeloma plasmocytes of the patients were examined by flow cytometry using the double staining method, and selected laboratory parameters of the disease were analyzed. It was revealed that the values of the PI index examined with the aid of different "identification" monoclonal antibodies did not differ significantly. The median and average value of the PI index was in the whole group for PI/CD38 2.3 and 2.3%, for PI "UHKT" 1.8 and 1.8% and for PI/B-B4(CD138)...
[Importance of determining the propidium-iodide index of plasmacytes in multiple myeloma. II. Relation to disease extent and activity].
V Scudla, M Ordeltová, A Spidlová, J Bacovský, M Budíková, K Srovnalík
Vnitr Lek 1999, 45(6):336-341
The authors evaluated in a group of 50 patients with multiple myeloma (MM), examined when the diagnosis was established before onset of treatment, and in a group of 85 patients examined in different stages of MM the relationship of proliferative characteristics of myeloma plasmocytes assessed by means of the propidium-iodide index PI/CD38, PI/"UHKT" and PI/B-B4(CD138) with the progression, "performance status" and the activity of the disease. With the exception of a different value of the PI/CD38 index between stages 1 and 3 evaluated according to Durie-Salmon, in the whole group of patients no relationship was found with the progress of the disease....
[Poor response in patients with de novo acute myeloid leukemia and erythroblastic or megakaryocytic dysplasia to treatment with standard doses of cytosine arabinoside and daunorubicin].
P Lemez, J Gáliková, T Haas
Vnitr Lek 1999, 45(6):342-346
Erythroid and/or megakaryocytic dysplasia (EMD) was evaluated in diagnostic bone marrow smears of 37 consecutively treated cases with de novo acute myeloid leukemia (AML) M0-M2 and M4-M5 types and three newly diagnosed cases of refractory anaemia with excess of blasts in transformation. This evaluation was possible in 38 of 40 (95%) patients and 17 cases were categorized without EMD and 21 cases with EMD. One or two cycles with 3-4 doses of daunorubicin 45 mg/m2/d and cytosine arabinoside 200 mg/m2/12 h x 14 lead to complete remission in 13 of 16 cases without EMD but only in 4 of 16 cases with EMD (p = 0.004). However, 10 of 13 patients with EMD reached...
[Personal experience with determination of carbohydrate-deficient transferrin].
D Stejskal, J Vavrousková, M Franková, L Jedelský, D Horalík, R Pastorková
Vnitr Lek 1999, 45(6):347-352
Assessment of carbohydrate-deficient serum transferrin CDT) is considered a very useful indicator of alcohol abuse. There is a number of methods for assessment of CDT. In clinical practice most frequently assessment of the percentage ratio of CDT in transferrin is used. In our hospital we assessed CDT by the method of homogeneous immunoanalysis (Boehringer Mannheim (CDT-BM). Because we obtained a relatively high percentage of false results and because we found in the literature reference to a new method of homogeneous immunoanalysis (The Sanqui BioTech-CD-SB) with a different cut-off, we decided to compare the results of the estimations by the two...
[Antioxidants and cardiovascular diseases in the Czech population].
M Bobák, Z Skodová, P Vojtísek, E Brunner, H W Hense, M Marmot
Vnitr Lek 1999, 45(6):353-358
The authors studied the possible association between plasma antioxidants and the high rates of cardiovascular diseases in the Czech Republic. The report has three parts. First, plasma antioxidants levels were compared in a random sample of population of two Czech districts (70 men and 66 women) and in British civil servants (246 men and I 12 women). Second, plasma antioxidants were compared in random samples of men aged 45-64 in Pardubice (Czech Republic, n = 185) and Augsburg (Bavaria, n = 142). Both Breat Britain and Bavaria have substantially lower mortality from cardiovascular disease than the Czech Republic. Third, a case control study examined...
[Pain and rheumatoid arthritis].
Z Macejová, I Nagyová, A Szilasiová, M Kovarová, B Spisák
Vnitr Lek 1999, 45(6):359-363
OBJECTIVE: Chronic pain is an important part of the clinical picture in patients with RA and therefore the authors attempted to assess the relationship of pain of patients with RA to the inflammatory process, articular damage and to predict the variance of pain in relation to psychosocial, demographic factors and functional disability.METHOD: Pain was examined using the Nottingham Health Profile (NHP), psychological health by means of the General Health Questionnaire (GHQ) and disability was assessed by the Health Assessment Questionnaire (HAQ).RESULTS: The authors examined 160 patients with RA with a mean age of 48.34 +/- 12.13 years and persistence...
[Anticoagulation therapy and bone metabolism].
V Krislo, P Dubac, M Sorf, V Krislo, A Sláviková, L Klubertová
Vnitr Lek 1999, 45(6):364-366
The effect of anticoagulation treatment with coumarin and heparin on bone metabolism is in recent years frequently discussed in professional journals. Its ever expanding use in the treatment of patients deserves therefore attention in particular in patients having prolonged anticoagulation treatment. In the submitted paper the authors investigated the effect of Warfarin on some indicators of bone metabolism in a group of 17 patients. In the investigated parameters such as estimation of parathormone, serum calcium, phosphatemia, isoenzyme of alkaline phosphatase they did not reveal any statistically significant changes during coumarin treatment.
[Indicators of oxidative stress in cardiovascular diseases. I. Lipoperoxidation].
J Racek, V Holecek, L Trefil
Vnitr Lek 1999, 45(6):367-372
The level od malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARS) respectively, in blood is changing very quickly and therefore isoprostanes scam to be better markers of atherogenesis. Oxidized LDL belong to the most important reasons of the origin of foam cells and therefore of atherogenesis. That is why the inhibition of the oxidation of LDL particles should belong to the standard therapy of cardiovascular diseases. The value of antibodies against oxidized LDL is difficult to interpret, because they are multifactor dependent, especially under genetic control. Antibodies against LDL modified by malondialdehyde (MDA-LDL) are increased...
[Indicators of oxidative stress in cardiovascular diseases. II. Nitrogenous substances, AGE-substances and antioxidants].
J Racek, V Holecek, L Trefil
Vnitr Lek 1999, 45(6):373-378
By oxidation of nitrogen oxide nitrites and nitrates are formed which can be considered markers of inflammation. AGE-substances (products of advanced glycation) are formed not only from proteins (e.g. Hb-AGE) but also from lipids (AGE-LDL) and DNA (AGE-DNA) and lead to an increased number of mutations. They are toxic and are deposited in the vascular wall. They cause coagulopathy, stimulate cytokines and inactivate nitrogen oxide and thus prevent relaxation of the vascular wall. Extracellular superoxide dismutase (EC-SOD) has a variant (mutation Arg213Gly with a 4% incidence) which causes deterioration of the cardiac prognosis. Selenium deficiency...
[Pathology of the spleen in ultrasonographic imaging].
E Goncalvesová, A Kovác, M Szántová
Vnitr Lek 1999, 45(6):379-383
Authors provide review on diffuse and focal splenic lesions, traumatic injuries, contribution of ultrasonography in staging of malignant lymphomas and ultrasound-guided percutaneous biopsy. Special attention is given to the question of normal spleen size and diagnosis of splenomegaly. In 230 patients (98 males) aged 18-72 years (median 34.2) witch underwent complex preventive examination, maximal longitudinal diameter (LDmax) of the spleen were measured. Using linear regression analysis relation of spleen size and body high, weigh and body mass index (BMI) was evaluated. Median LDmax was 10.1 cm, range 7.8-13.5 cm. As a reference limit authors accept...
[Hemophilic arthropathy as a multidisciplinary problem].
V Krislo, O Masek, M Sorf, V Krislo, P Dubac, A Slávková, L Klubertová, P Muth, Z Macejková
Vnitr Lek 1999, 45(6):384-387
The authors have at present on their records in Slovakia 422 patients with haemophilia type A, i.e. 7.9 per 100,000 population, 76 cases of haemophilia type B, i.e. an incidence of 1.4, 189 patients with von Willebrand's disease with an incidence of 3.6 and 215 patients with hypoconvertinaemia with an incidence of 3.98 per 100,000 population. The authors present an account on the most frequent complications of haemophilia with special attention to haemorrhage into the joints and the development of serious haemophilic arthropathies. They emphasize the great contribution of team work of different medical specialists who participate in the diagnosis and...