Vnitr Lek 1999, 45(6):373-378
[Indicators of oxidative stress in cardiovascular diseases. II. Nitrogenous substances, AGE-substances and antioxidants].
- Ustav klinické biochemie a laboratorní diagnostiky LF UK a FN, Plzen.
By oxidation of nitrogen oxide nitrites and nitrates are formed which can be considered markers of inflammation. AGE-substances (products of advanced glycation) are formed not only from proteins (e.g. Hb-AGE) but also from lipids (AGE-LDL) and DNA (AGE-DNA) and lead to an increased number of mutations. They are toxic and are deposited in the vascular wall. They cause coagulopathy, stimulate cytokines and inactivate nitrogen oxide and thus prevent relaxation of the vascular wall. Extracellular superoxide dismutase (EC-SOD) has a variant (mutation Arg213Gly with a 4% incidence) which causes deterioration of the cardiac prognosis. Selenium deficiency leads also to an increased frequency of cardiovascular diseases.
Keywords: Antioxidants, metabolism, ; Cardiovascular Diseases, metabolism, ; Glycation End Products, Advanced, metabolism, ; Humans; Nitrogen Compounds, metabolism, ; Oxidative Stress
Published: June 1, 1999 Show citation