[Immunophenotyping in chronic B-cell lymphatic leukemia].

O Kopecký, J Krejsek, J Voglová, V Derner

Vnitr Lek 1994, 40(3):145-150

The authors present the results of immunophenotyping analysis of cells from 67 patients with the diagnosis of B-CLL from group of 393 adults examined by immunophenotyping because of a haematological malignity. Characteristic for B-CLL is the finding of surface molecules HLA DR, B lymphocytic superficial molecules and CD5. Aberrant membrane equipment of B-CLL cells is suggested by the rare absence of some pan B lymphocytic sign. Marked reduction of T lymphocyte ratios, their sub-populations and NK cells is associated with immunodeficiency manifestations which are common in patients with B-CLL.

[Serum thymidine kinase in multiple myeloma: I. Relation to selected laboratory indicators in the disease].

V Scudla, J Bacovský, T Papajík, M Budíková, K Srovnalík

Vnitr Lek 1994, 40(3):151-156

In a group of 74 patients with multiple myeloma the authors revealed elevated values of serum thymidine kinase (REA kit ADICO Praha, range of normal values 0-5 U/l) in 40% of the patients-incl. a group of 22 subjects examined at the time of diagnosis of the disease in 50%, and a group of 52 subjects examined in different stages of the disease in 36% of the patients. If the upper range of S-TK 10 U/l was used, the ratio of patients with a raised value declined to 15%, in selected groups to 18 and 14% resp. The authors found a satisfactory correlation of serum thymidine values and values of S-beta-microglobulin, S-albumin, with the percentage ratio of...

[Serum thymidine kinase in multiple myeloma: II. Relation to disease activity and stage].

V Scudla, T Papajík, J Bacovský, M Budíková, D Klímová

Vnitr Lek 1994, 40(3):157-162

In a group of 74 patients with multiple myeloma examined in different developmental stages of the disease the authors evaluated the clinical impact of assessment of the serum thymidine kinase (S-TK) activity. They recorded a significant relationship of S-TK values and the clinical activity of the disease (increase in 75% of the patients with the clinically active form of myeloma) and the general clinical condition ("performance status") evaluated by means of a five-grade scale. The authors tested the relationship of S-TK values and the degree of multiple myeloma, i.e. the clinical stage of the disease tested according to Durie-Salmon's classification...

[Children of parents treated for Hodgkin's disease using irradiation and chemotherapy].

Z Dienstbier, Z Hermanská, J Zámecník, L Melínová, E Skala, B Vacková

Vnitr Lek 1994, 40(3):163-166

The authors describe data on the course of pregnancy, delivery and subsequent development of 20 children born to parents treated for Hodgkin's disease. Thirteen women in the clinical stage II and III were delivered of 16 infants (10 daughters and 6 sons) and three men (II A and III A) had four daughters. The parents were in one case treated by irradiation only, twice by chemotherapy only and thirteen times by a combination of irradiation and chemotherapy (COPP/ABVD). The gestation period, parameters of the infants at delivery and the subsequent physical and mental development are normal. In one instance (a girl, now ten and a half years old) the child...

[Large blood platelets--risk factors in myocardial infarction].

S Funiak, J Květenský, J Hudecek, M Belicová, J Stasko, I Markuljak, P Kubisz

Vnitr Lek 1994, 40(3):167-169

Thrombocytes participate in the pathogenesis of myocardial infarction. Larger platelets are more active than small ones. In patients after an acute coronary a larger number of platelets was found, a medium volume of půatelets and a similar thrombocytocrite as compared with the healthy population of comparable structure and age. The MPV in patients of advanced age is statistically significantly larger. There are no significant correlations between MPV and the risk factors investigated by the authors.

[Is it possible to predict a decrease in portal pressure after administration of ACE inhibitors?].

P Svoboda, I Kantorová, J Ochmann

Vnitr Lek 1994, 40(3):170-173

We have previously shown that angiotensin converting enzyme inhibitor enalapril causes a potent decrease in portal pressure gradient, but only in about one half of patients with portal hypertension and an episode of bleeding esophageal varices in patient's history. Twenty-one consecutive patients after first episode of bleeding from esophageal varices were enrolled in the trial. Patients were treated by sclerotherapy in combination with enalapril. The level of ACE in patients with portal hypertension (10.4, SD 4.5) was significantly higher than in normal population (4.5, SD 1.3 mu kat/l-1) [p < 0.001]. After 3 months treatment decreased ACE to normal...

[Iron stores in patients with chronic kidney failure treated with recombinant human erythropoietin].

J Cermák, E Gregora, J Lachmanová, V Brabec

Vnitr Lek 1994, 40(3):174-178

Nine patients with anemia of chronic renal failure were treated with recombinant human erythropoietin (rHuEPO) in dose 50-150 IU/kg/week. After 8 weeks the treatment was maintained with 30-50 IU/kg/week for one year. A significant increase of hemoglobin (Hb) level and red blood cell (RBC) count was observed in all patients. Administration of rHUEPO maintained Hb level higher than 100 milligrams and RBC count above 3.0 x 10(12)/l. Iron stores decreased in all patients. Parameters reflecting either the real amount of iron available for erythropoiesis or iron stores in erythroid precursors, i.e. red cell ferritin (eF), free erythrocyte protoporphyrin...

[Use of bronchoalveolar lavage in the diagnosis of pulmonary complications in immunocompromised patients].

J Mayer, J Skricková, J Vorlícek, V Kubálek

Vnitr Lek 1994, 40(3):179-183

The authors examined, using bronchoalveolar lavage, 70 immunocompromised patients with pulmonary complications. The bronchoalveolar fluid was subjected to cytological and microbiological examination. The examination was not associated with any serious undesirable side effects, not even in patients who were in a serious general condition. Based on the examination the treatment was changed in 83% of the patients and the correctness of treatment was confirmed in 7% of the patients. In 76% of the patients the condition improved. It was possible for instance to diagnose pneumonia caused by Pneumocystic carinii, the Herpes simplex virus and fungi even in...

[Methods of recording late ventricular potentials as a basis for their rational clinical use].

M Dúbrava

Vnitr Lek 1994, 40(3):184-189

The risk of development of ventricular arrhythmias can be evaluated at present also by examination of late ventricular potentials. Late ventricular potentials are high-frequency low-amplitude signals which develop in the terminal part of the QRS complex and are the manifestation of retarded excitation in the myocardial area where islets of vital muscle alternate with islets of fibrosis and/or necrosis. Their detection is very pretentious as regards recording and processing of the electrocardiographic signal. Only relatively complicated procedures ensure that the result of the examination has a clinically acceptable sensitivity and specificity. These...

[Ebstein's anomaly in a 66-year-old woman].

J Mach, M Grézl

Vnitr Lek 1994, 40(3):190-191

The authors describe a case of Ebstein's anomaly in a 66-year-old woman. The first, and almost only clinical manifestation of the disease was atrial flutter at the age of 56 years with rapid restoration of the sinus rhythm after pharmaceutical treatment. The authors analyze the causes of the favourable development of the disease and draw attention to the possibility of mild forms of Ebstein's anomaly even in advanced age.

[A rare symptom of peptic ulcer perforation: subcutaneous emphysema].

M Zuffa, F Rusnák, E Dorociaková

Vnitr Lek 1994, 40(3):192-193

The authors describe a 50-year-old man who was hospitalized on account of one-week increasing epigastric pain with marked regression several hours after admission. The revealed small subcutaneous emphysema near the umbilicus directed the diagnostic procedure and led to detection of a covered perforation of a peptic prepyloric ulcer.

[Use of natriuretic peptides in clinical practice].

I Lazúrová, H J Kramer

Vnitr Lek 1994, 40(3):194-198

Due to its physiological and pharmacological action ANF could be an ideal diuretic and vasorelaxation product in the treatment of oedema and essential hypertension. Experimental and clinical investigations in oedematous conditions revealed a very slight diuretic and natriuretic effect of ANF, as compared with healthy subjects. This is due to the reduced renal perfusion pressure, the increased RAAS activity, enzymatic degradation of ANF by endopeptidase and also its inactivation via C-receptors. Moreover the use of ANF is very limited due to its short half-life and peptide structure. In recent years therefore new possibilities are sought how to influence...

[Interferon alfa in the treatment of hairy cell leukemia].

Z Adam

Vnitr Lek 1994, 40(3):199-202

For patients with hairy cell leukemia, with regard to the cost of interferon treatment, splenectomy is the treatment of choice. In patients who do not respond to splenectomy or have relapses, the drug of choice is interferon alpha, 3 x 10(6) i.u.s.c. daily till remission occurs and then three times per week for a period of 18-24 months. After this period treatment can be terminated, it is however better to proceed permanently with lower maintenance doses. During a relapse interferon alpha is again administered, and if the disease does not respond, it is recommended to test a different interferon preparation or deoxycoformycin or chlorodeoxyadenosine.

[The first selective coronarography in Czechoslovakia].

I Simkovic

Vnitr Lek 1994, 40(3):203-204

[Diabetes mellitus in general practice. Summary of standard care of type II diabetes mellitus for the general practitioner. The Czech Diabetology Society and the Society of General Medicine].

Vnitr Lek 1994, 40(3):206-208