[Minor glomerular abnormalities in chronic tubulointerstitial nephritis].

I Slugen, D Danis, O Nyitrayová, S Nyulassy, M Pavlovic, K Furková, A Slováková, P Hlavcák

Vnitr Lek 1994, 40(12):757-759

The authors examined consecutive renal biopsies from 43 patients with minor glomerular abnormalities and from 35 patients with chronic tubulointerstitial nephritis (in the least affected glomeruli). The findings were evaluated according to WHO criteria of minor abnormalities. They found that significantly more frequently lipid drops were found in minor abnormalities (6:0), as well as changes in the capillaries of glomeruli (breakdown 1:7), wrinkling (15:29-highly significant even after correction of p)) in tubulointerstitial nephritis. The incidence in another 15 compared indicators there was not significantly different. With regard to the assembled...

[The role of the HUT test (head upright tilt table test) in patients with syncope of uncertain etiology].

R Dvorák, M Kozák, B Semrád

Vnitr Lek 1994, 40(12):760-764

UNLABELLED: The authors have examined 73 patients at the mean age of 36.8 +/- 15.3 (M:34, F:39). All the pts have suffered from recurrent presyncopes or syncopes the etiology of which has not been diagnosed by previous internal, neurological or psychiatric examination. Before the HUT the patients have undergone a complete cardiological examination. The HUT has been carried out according to the modificated Westminster protocol, the blood pressure and the heart rate have been monitored continuously. The end-point of the HUT has been a presyncope or a syncope, viewed as positive. The positive pts have been divided into 4 groups according to the changes...

[Complications of central venous catheterization in hematologic patients--prospective study of 193 catheterizations].

E Faber, K Mociková, B Grochal, S Koróny, L Matecek

Vnitr Lek 1994, 40(12):765-769

A Prospective Study of 193 Catheterizations 193 central venous catheters introduced in 142 patients with haematological diseases were studied prospectively for complications in 1984-1992. 165 polyethylene, 14 Hickman and 14 polyurethane catheters were inserted into subclavian vein via infraclavicular access using Seldinger technique exclusively. Except bleeding, that was not serious, immediate complications occurred in 4%. Cumulative duration of catheterizations was 6370 days with median duration of one cannulation of 15 days, range 1 to 489 days. In polyethylene catheters duration of catheterization was influenced significantly by tunnelization. More...

[The Pelger-Huët anomaly].

O Měricka, V Lexová, K Smetana

Vnitr Lek 1994, 40(12):770-772

The authors describe a case-history of Pelger-Huët anomaly in a 53-year-old patient with bronchogenic carcinoma. It was not possible to reveal whether an inborn or acquired anomaly was involved. Recent knowledge of this problem is discussed.

[Resistance to activated protein C, so-called APC resistance: the first two cases in Slovakia].

J Hudecek, J Ivánková, P Kubisz

Vnitr Lek 1994, 40(12):773-775

For the anticoagulant action of activated protein C (APC) in addition to protein S another newly detected cofactor is essential. Its deficiency is described as APC-resistance. This defect which is closely associated with the molecule of the factor V seems to be the most frequent cause of thrombophilia. The authors describe two patients where APC-resistance was diagnosed for the first time in Slovakia.

[Is oral contraception safe?].

P Navrátil, P Schlemmer, M Hasková, V Meissner

Vnitr Lek 1994, 40(12):776-778

[Anticoagulation therapy in patients with valvular prostheses].

J Chlumský

Vnitr Lek 1994, 40(12):779-782

Thromboembolism and haemorrhage are the most frequent complication in patients after valvular prostheses or provision of a mechanical replacement. Optimal anticoagulant treatment reflects efforts to reduce these main two complications to a minimum. The author summarizes contemporary recommendations for anticoagulant treatment of these patients under standard conditions and therapeutic procedures in complications such as surgery, pregnancy and embolism into the CNS.

[Is it possible to prevent mycotic infections in oncology patients?].

J Mayer, J Vorlícek

Vnitr Lek 1994, 40(12):783-788

The authors give an account on prophylactic provisions focused on reduction of the risk of mycotic infections in oncological patients. After a brief introduction where they point out the importance of mycotic infections they pay their main attention to the prophylactic administration of drugs. They deal with procedures used and in the majority they quote original sources. Main emphasis is laid on the probably most perspective preparation-fluconazol. The authors present also their own views.

[Cisplatin and carboplatin in the treatment of malignant lymphoma and multiple myeloma].

Z Adam, J Mayer, R Hájek

Vnitr Lek 1994, 40(12):790-800

Experiences with cisplatin and carboplatin are summarized in this paper. The treatment response to monotherapy with cisplatin or carboplatin was proved in non-Hodgkin's lymphomas. This is necessary condition for the application of the drug in polychemotherapy. Cisplatin and carboplatin based combinations are not used as an initial therapy. The indications for these two drugs are primary resistant malignant lymphoma and multiple myeloma, or relapses of these diseases not responding to conventional therapy. Cisplatin based combination therapy can in these indications prolong the survival in 30-40% of patients. The role of carboplatin in malignant lymphoma...