Vnitřní lékařství, 1989 (vol. 35), issue 1
[Treatment of severely depressed hematopoiesis].
M Bláha, V Maisnar, L Jebavý, J Malý, O Siroký
Vnitr Lek 1989, 35(1):1-8
Severe inhibition of haematopoiesis is a serious disease from the prognostic aspect. The authors evaluated a group of 26 patients of whom one survived for more than five years. The mean life span is 154 days. The most frequent cause of death are infectious complications, in particular septicaemia. Investigation of the aetiology of the disease was negative in 46% of the cases, in the remainder drugs were suspected most frequently, in particular antibiotics. It is very important to prevent the development of secondary inhibition of haematopoiesis, in particular by careful indication of myelotoxic drugs. In case of necessity, these drugs should be administered...
[Clinical evaluation of granulocyte concentrates in the treatment of malignant disorders of hematopoiesis].
K Mociková, Z Vrlíková, B Wildová, E Faber
Vnitr Lek 1989, 35(1):9-15
The authors evaluate in a retrospective, non-randomized two-year study the action of 57 granulocyte concentrates from a Fenwal CS 3000 separator in 12 patients used for induction therapy of acute leukaemia, malignant lymphoma and agranulocytosis, as compared with a control group of 18 patients without concentrates. The indication for selection was granulocytopenia of less than 0.5.10(9)/l, temperatures resistant to antibiotics for more than 48 hours, mainly gram-negative sepsis and a severe localized infection. A significant reduction of febrile days was achieved, to 6.08 as compared with 12.44 (p less than 0.001) along with cure of the infection....
[Immunoenzyme phenotyping of cells of domestically-produced monoclonal antibodies on dried smears of peripheral blood and bone marrow].
V Koza, P Cetkovský
Vnitr Lek 1989, 35(1):16-22
The authors describe the indirect immunoperoxidase method which makes possible immunophenotyping of cells on dried smears of peripheral and bone marrow. They used only local currently available monoclonal antibodies with a diagnostic value in lymphoproliferative conditions. The above procedure makes it possible to examine stored non-fixed smears, to evaluate the morphology of positive and negative cells and to evaluate findings retrospectively.
[Long-term study of disorders of heart rhythm in patients with chronic diseases of the respiratory system].
B Král, P Tilser, J Gregor, M Pospísil, A Strasová, J Eliás, V Havel
Vnitr Lek 1989, 35(1):23-29
The authors investigated the incidence of arrhythmias by the method of continuous recording of ECG tracings according to Holter in 16 patients with chronic respiratory diseases three times in the course of two years. The incidence of arrhythmias was very frequent, more serious disorders (class 3 or a higher class according to Lown's classification) were very rare. The authors provided evidence of a great variability in the incidence of arrhythmias in the same patients during different periods of investigation. They did not reveal a relationship between the incidence of arrhythmias and the degree of functional affection of the lungs, the severity of...
[Changes in blood pressure in mild forms of hypertension after long-term physical training].
H Nĕmcová, I Dvorák, M Blaha, J Spác
Vnitr Lek 1989, 35(1):30-35
The authors submit the results of a long-term study of the treatment of mild hypertension by physical training. Its advantage, as compared with medicamentous treatment, is the physiological effect on the organism, its financially unpretentious character, and if the population is seriously informed, its wide application. The authors found in general a poor approach to physical activity, in particular among young people due to lack of information on the importance of physical activity. They conclude that physical training is the method of choice in the treatment of mild forms of hypertension. The blood pressure attained normal levels after this treatment...
[The somatotropic hormone and liver diseases].
P Weber, K Martínek, Z Cechácek
Vnitr Lek 1989, 35(1):36-42
The authors examined in 1980-1988 a total of 114 patients aged 18-87 years suffering from chronic liver disease. In all these patients they examined in addition to RIA assay of somatotropic hormone (STH) bilirubin and basic liver enzymes, using common methods. They recorded a significant increase of STH in patients with cirrhosis of the liver. In the other diagnostic groups the STH levels were within the reference zone or at its upper borderline. The authors analyzed also STH levels in relation to diabetes and drew attention to its frequent occurrence (type II) in patients with cirrhosis of the liver. The authors analyze also STH variations in the...
[Relation of HLA antigens and the length of survival in patients with acute leukemia].
J Prazák
Vnitr Lek 1989, 35(1):43-49
The authors examined and evaluated by statistical methods 80 patients with acute leukaemia (AL). The group comprised 56 myeloid (AML) and 24 lymphocytic (ALL) leukaemias. In AL and AML no significant relations with transplantation antigens were detected. In ALL an increased frequency of HLA-B5 was found which was statistically significant (Fischer's test pc = 0.046). In women, as compared with men, an increased frequency of antigens A28, B17 was found and a reduction of HLA-B35. The values were not statistically significant. The authors sought relationships between the presence or absence of some HLA antigens (A2, A3, A10, B12) and the survival period...
[Do HLA-B37 and HLA-B27 antigens cross react?].
A Májský
Vnitr Lek 1989, 35(1):50-51
Anti-HLA-B37 serum of Behringwerke gave a positive cytotoxic test with 18 of 24 samples of B37 negative B27 positive lymphocytes. With lymphocytes which had none of these antigens the reaction was always negative. The author discusses whether the results are evidence of the cross reactivity between antigens HLA-B37 and B27 or whether it is due to traces of anti-HLA-B27 antibodies in the above serum.
[Clinical importance of changes in antibody immunity in gout].
Z Hrncír, V Krupar, P Bradna, M Tichý
Vnitr Lek 1989, 35(1):52-57
In 77 patients with gout (16 with acute attacks and 61 during an attack-free period), in 30 healthy subjects, 30 patients with IgM RF serum positive rheumatoid arthritis (RA) and 20 cases of IgM RF serum negative RA the authors examined serum values of 10 parameters of antibody immunity: IgA, IgG, IgM, IgD, IgE, beta-2 microglobulin (beta-2 MG), immunocomplexes (IK), IgM RF/LFT, IgM/RF/HAT and ANA/IF. Data obtained by quantitative analyses were processed by stepwise discrimination with the consecutive selection of characteristics significant for the differentiation of the investigated groups and by assessment of classification functions which make...
[The Apple II e microcomputer as a databank for registering special donors].
M Láznicka, J Sejkorová, J Hajic, T Korbelárová
Vnitr Lek 1989, 35(1):58-61
The authors introduced in the Institute of Haematology and Blood Transfusion in Prague records of special donors, voluntary donors of bone marrow and voluntary donors for the separator using the microcomputer Apple II and the system ArchTex. These provisions make it possible to select a suitable donor much more quickly than by the hitherto used system of cards which, however, still are essential for the work of the special donor station.
[Results of a clinical trial of sulfasalazine in rheumatoid arthritis].
Z Pelísková, K Trnavský, J Gatterová, J Macek
Vnitr Lek 1989, 35(1):62-67
The authors tested the therapeutic effectiveness and tolerance of the sulphonamide chemotherapeutic preparation sulfasalazine in 69 patients with active rheumatoid arthritis. A one-year open clinical investigation was completed by 41 patients (59%) where in the course of treatment significant improvement of the majority of clinical and laboratory indicators of the activity of the rheumatic process was recorded. Treatment was terminated prematurely by 28 patients (41%) incl. 16 (23%) where treatment was discontinued because of undesirable side-effects which developed most frequently during the first months of treatment and were not very serious. X-ray...
[Pachydermoperiostosis--development of bone changes 25 years after disease onset].
D Míková
Vnitr Lek 1989, 35(1):68-73
Pachydermoperiostosis-hyperostosis generalisata cum pachydermia is considered a sex-linked hereditary pathological disposition of the mesenchyme with a favourable course of the dominant form; it is, however, progressively malignant in the recessive type of heredity. As a rule men affected. The author describes the case of a patient where the disease was diagnosed 25 years previously.
[Carcinoid of the duodenum in neurofibromatosis].
J Skála, M Procházka, P Hrabal
Vnitr Lek 1989, 35(1):74-78
The authors described a very rare case of duodenal carcinoid in neurofibrimatosis in a 53-year-old patient who was treated by local excision of the tumour. In the discussion they draw attention to the possible development of carcinoid in neurofibromatosis as a manifestation of systemic affection of neuroectodermal tissues.