Vnitr Lek 2025, 71(1):E8-E13 | DOI: 10.36290/vnl.2025.012

Nutrition and its role in the primary prevention of osteoporosis

Matej Kohutiar1, Monika Bartolomějová2, Magdaléna Fořtová1,3, Eva Klapková1, Jana Čepová1
1 Ústav lékařské chemie a klinické biochemie 2. lékařské fakulty Univerzity Karlovy a Fakultní nemocnice v Motole, Praha
2 Psychiatrická klinika 1. lékařské fakulty Univerzity Karlovy a Všeobecné fakultní nemocnice, Praha
3 Oddělení klinické biochemie, hematologie a imunologie, Nemocnice Na Homolce, Praha

Osteoporosis is a chronic metabolic bone disease that results from an imbalance between bone formation and resorption. Bone remodeling is a dynamic process influenced by genetic factors, nutrition and physical activity. Calcium, phosphorus, and vitamin D are key nutritional factors in the prevention and treatment of osteoporosis, but due to the complexity of bone tissue, other nutrients must also be considered. This article summarizes the importance of each nutrient, discusses the risks associated with inappropriate dietary habits, increasing consumption of ultra-processed foods and emphasizes the importance of overall lifestyle in the prevention of osteoporosis. This review offers a comprehensive view of the role of individual nutrients in the primary prevention of osteoporosis in the context of current trends and provides practical recommendations for maintaining bone health.

Keywords: bone metabolism, malnutrition, micronutrients, minerals, nutrition, osteoporosis, prevention, vitamin D, nutrition

Accepted: February 7, 2025; Published: February 18, 2025  Show citation

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Kohutiar M, Bartolomějová M, Fořtová M, Klapková E, Čepová J. Nutrition and its role in the primary prevention of osteoporosis. Vnitr Lek. 2025;71(1):E8-13. doi: 10.36290/vnl.2025.012.
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    References

    1. MeDitorial [online]. SCOPE 2021 - stav osteoporózy a její léčby v evropských zemích, 2023 [cit. 2024-07-24]. Available from https://www.prolekare.cz/tema/Osteoporoza_trendy_v_ST/detail/scope-2021-stav-osteoporozy-a-jeji-lecby-v-evropskych-zemich-135134
    2. Henry YM, Fatayerji D, Eastell R. Attainment of peak bone mass at the lumbar spine, femoral neck and radius in men and women: relative contributions of bone size and volumetric bone mineral density. Osteoporos Int. 2004;15(4):263-73. Go to original source... Go to PubMed...
    3. Feng X. Chemical and Biochemical Basis of Cell-Bone Matrix Interaction in Health and Disease. Curr Chem Biol. 2009;3(2):189-96. Go to original source...
    4. Price CT, Langford JR, Liporace FA. Essential Nutrients for Bone Health and a Review of their Availability in the Average North American Diet. The Open Orthop J. 2012;6:143. Go to original source... Go to PubMed...
    5. Nařízení Komise (ES) č. 1170/2009 ze dne 30. listopadu 2009, kterým se mění směrnice Evropského parlamentu a Rady 2002/46/ES a nařízení Evropského parlamentu a Rady (ES) č. 1925/2006, pokud jde o seznamy vitaminů a minerálních látek a jejich forem, které lze přidávat do potravin, včetně doplňků stravy. In: EUR-Lex [právní informační systém]. Úřad pro publikace Evropské unie [cit. 2025-01-30]. Available from: https://eur-lex.europa.eu/
    6. Státní ústav pro kontrolu léčiv [online]. SÚKL © 2025, [cit. 2025-02-05]. Available from: https://sukl.gov.cz/
    7. Tong TYN, Appleby PN, Armstrong MEG, et al. Vegetarian and vegan diets and risks of total and site-specific fractures: results from the prospective EPIC-Oxford study. BMC Medicine. 2020;18(1):353. Go to original source... Go to PubMed...
    8. Referenční hodnoty pro příjem živin. V ČR 2. vyd. Praha: Výživaservis s.r.o., 2018. ISBN 978-3-86528-148-7.
    9. Office of Dietary Supplements - Calcium [online]. National Institutes of Health, 2024 [cit. 2025-02-01]. Available from: https://ods.od.nih.gov/factsheets/Calcium/HealthProfessional/#en3
    10. Heaney RP, Dowell MS, Bierman J, et al. Absorbability and cost effectiveness in calcium supplementation. J Am Coll Nutr. 2001;20(3):239-46. Go to original source... Go to PubMed...
    11. Rondanelli M, Faliva MA, Tartara A, et al. An update on magnesium and bone health. Biometals. 2021;34(4):715-36. Go to original source... Go to PubMed...
    12. Zadák Z, Tichá A, Hyšpler R. Suplementace hořčíku - farmakologické mechanismy, metody podání a pasti. Klin farmakol a farm. 2017;31(3):16-8. Go to original source...
    13. Kappeler D, Heimbeck I, Herpich C, et al. Higher bioavailability of magnesium citrate as compared to magnesium oxide shown by evaluation of urinary excretion and serum levels after single-dose administration in a randomized cross-over study. BMC Nutrition. 2017;3(1):7. Go to original source...
    14. Wielgus K, Dan M, Tavares T. Managing magnesium deficiency: Strategies for diagnosis and treatment. Evidence for Self-Medication. 2024; 4(240001):1-4. Go to original source...
    15. Carlberg C. Molecular endocrinology of vitamin D on the epigenome level. Mol Cell Endocrinol. 2017; 453:14-21. Go to original source... Go to PubMed...
    16. Carlberg C, Raczyk M, Zawrotna N. Vitamin D: A master example of nutrigenomics. Redox Biology. 2023; 62:102695. Go to original source... Go to PubMed...
    17. Bischofová S, Dofkova M, Blahová J, et al. Dietární zdroje vitaminu D v české populaci (4-90 let). Výživa a Potraviny. 2019; 3:58-60.
    18. Palička V, Rosa J, Pikner R, Býma S. Osteoporóza: doporučený diagnostický a terapeutický postup pro všeobecné praktické lékaře 2023. Doporučené postupy pro praktické lékaře. Praha: Centrum doporučených postupů pro praktické lékaře, Společnost všeobecného lékařství ČLS JEP, 2023. ISBN 978-80-88280-51-4.
    19. Tripkovic L, Lambert H, Hart K, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. Am J Clin Nutr. 2012; 95(6):1357-64. Go to original source... Go to PubMed...
    20. Poterucha TJ, Goldhaber SZ. Warfarin and Vascular Calcification. Amer J Med. 2016; 129(6): 635 e1-4. Go to original source... Go to PubMed...
    21. Merra G, Dominici F, Gualtieri P, et al. Role of vitamin K2 in bone-vascular crosstalk. Int J Vitam Nutr Res. 94(2):143-152. Go to original source... Go to PubMed...
    22. Khojah Q, Al Rumaihi S, Al Rajeh G, et al. Vitamin A and its dervatives effect on bone mineral density, a systematic review. J Family Med Prim Care. 2021; 10(11):4089-95. Go to original source... Go to PubMed...
    23. Olson JM, Ameer MA, Goyal A. Vitamin A Toxicity. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 [cited 2025-02-02]. Dostupné z: https://www.ncbi.nlm.nih.gov/books/NBK532916/
    24. Maxfield L, Daley SF, Crane JS. Vitamin C Deficiency. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. [cit. 2024-07-25] Dostupné z: https://www.ncbi.nlm.nih.gov/books/NBK493187/
    25. Hronek M, Kovařík M. Interakce vitaminů s léčivy. Interní medicína pro praxi. 2012; 14(6-7):275-80.
    26. Kositsawat J, Vogrin S, French C, et al. Relationship Between Plasma Homocysteine and Bone Density, Lean Mass, Muscle Strength and Physical Function in 1480 Middle-Aged and Older Adults: Data from NHANES. Calcif Tissue Int. 2023; 112(1):45-54. Go to original source... Go to PubMed...
    27. Behera J, Bala J, Nuru M, et al. Homocysteine as a Pathological Biomarker for Bone Disease. J Cell Physiol. 2017; 232(10):2704-9. Go to original source... Go to PubMed...
    28. Kalimeri M, Leek F, Wang NX, et al. Folate and Vitamin B-12 Status Is Associated With Bone Mineral Density and Hip Strength of Postmenopausal Chinese-Singaporean Women. JBMR Plus. 2020; 4(10):e10399. Go to original source... Go to PubMed...
    29. Hyánek J, Maťoška V, Dubská L, et al. Mírné hyperhomocysteinémie z deficitu MTHFR (C677T a C1298A) u dospělých a adolescentů v metabolické ambulanci. Je třeba je diferencovat a léčit? Klin Biochem Metab. 2017; 46(1):18-26. Go to original source...
    30. Carboni L. Active Folate Versus Folic Acid: The Role of 5-MTHF (Methylfolate) in Human Health. Integr Med 2022; 21(3):36-41.
    31. Kohout P, et al. Klinická výživa. 1. vyd. Praha: Galén, 2021. ISBN 978-80-7492-555-9.
    32. Rolić T, Yazdani M, Mandić S, et al. Iron Metabolism, Calcium, Magnesium and Trace Elements: A Review. Biol Trace Elem Res. 2024; Dostupné z: https://doi.org/10.1007/s12011-024-04289-z Go to original source... Go to PubMed...
    33. Národní zdravotnický informační portál [online]. Praha: Ministerstvo zdravotnictví ČR a Ústav zdravotnických informací a statistiky ČR, 2024 [cit. 2024-10-24]. Dostupné z: https://www.nzip.cz/clanek/1153-selen
    34. Dou Y, Wang Y, Chen Z, et al. Effect of n-3 polyunsaturated fatty acid on bone health: A systematic review and meta-analysis of randomized controlled trials. Food Sci Nutr. 2022; 10(1):145-54. Go to original source... Go to PubMed...
    35. Liu Z, Cai S, Chen Y, et al. The association between dietary omega-3 intake and osteoporosis: a NHANES cross-sectional study. Front Nutr. 2024; 11:1467559. Go to original source... Go to PubMed...
    36. Office of Dietary Supplements - Omega-3 Fatty Acids [online]. National Institutes of Health, 2024 [cit. 2024-10-24]. Dostupné z: https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/
    37. Rizzoli R, Biver E, Bonjour JP, et al. Benefits and safety of dietary protein for bone health-an expert consensus paper endorsed by the European Society for Clinical and Economical Aspects of Osteopororosis, Osteoarthritis, and Musculoskeletal Diseases and by the International Osteoporosis Foundation. Osteoporos Int. 2018; 29(9):1933-48. Go to original source... Go to PubMed...
    38. MeDitorial [online]. Aktuální pohled na problematiku příjmu proteinů u pacientů v kritickém stavu, 2022 [cit. 2025-02-01]. Dostupné z: https://www.prolekare.cz/tema/parenteralni-vyziva/detail/aktualni-pohled-na-problematiku-prijmu-proteinu-u-pacientu-v-kritickem-stavu-130687
    39. König D, Oesser S, Scharla S, et al. Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study. Nutrients. 2018; 10(1):97. Go to original source... Go to PubMed...
    40. Lichtenstein AH, Appel LJ, Vadiveloo M, et al. 2021 Dietary Guidance to Improve Cardiovascular Health: A Scientific Statement From the American Heart Association. Circulation. 2021; 144(23):e472-87. Go to original source... Go to PubMed...
    41. Mendoza K, Smith-Warner SA, Rossato SL, et al. Ultra-processed foods and cardiovascular disease: analysis of three large US prospective cohorts and a systematic review and meta-analysis of prospective cohort studies. Lancet Reg Health Am. 2024; 37:100859. Go to original source... Go to PubMed...
    42. Monteiro CA, Cannon G, Levy RB, et al. Ultra-processed foods: what they are and how to identify them. Public Health Nutr. 2019; 22(5):936-41. Go to original source... Go to PubMed...
    43. Zikán V. Osteoporóza u dospělých osob v klinické praxi (1): diagnostika a diferenciální diagnostika. Vnitřní lékařství. 2023; 69(4):E4-15. Go to original source... Go to PubMed...
    44. Lane MM, Gamage E, Du S, et al. Ultra-processed food exposure and adverse health outcomes: umbrella review of epidemiological meta-analyses. BMJ. 2024; 384:e077310 Go to original source... Go to PubMed...
    45. Mertens E, Colizzi C, Peñalvo JL. Ultra-processed food consumption in adults across Europe. Eur J Nutr. 2022; 61(3):1521-39. Go to original source... Go to PubMed...

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