Vnitr Lek 2025, 71(1):40-44 | DOI: 10.36290/vnl.2025.007

Humoral biomarkers and atrial fibrillation

Martin Ihnatko, Ivica Lazúrová
I. interná klinika UPJŠ LF a UNLP, Košice

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice, contributing to increased morbidity and mortality. Humoral biomarkers, such as natriuretic peptides, troponin, aldosterone, cortisol, copeptin, and apelin, are gaining importance in the diagnosis, prognosis, and management of AF. Elevated levels of these biomarkers indicate not only myocardial dysfunction and atrial remodeling but also inflammatory and procoagulant states that influence the progression and complications of AF. Monitoring biomarker levels provides deeper insight into the pathophysiological mechanisms of AF and can aid in identifying patients at higher risk of complications, such as thromboembolic events or disease progression. Integrating biomarkers into clinical practice can significantly improve risk stratification, facilitate a more personalized approach to AF treatment, and contribute to more effective disease monitoring. Evidence linking biomarkers with AF is promising; however, further studies are needed to confirm their clinical utility in standard care for patients with this serious condition.

Keywords: aldosterone, apelin, atrial fibrillation, copeptin, cortisol, natriuretic peptides, troponin.

Accepted: February 6, 2025; Published: February 18, 2025  Show citation

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Ihnatko M, Lazúrová I. Humoral biomarkers and atrial fibrillation. Vnitr Lek. 2025;71(1):40-44. doi: 10.36290/vnl.2025.007.
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