Vnitr Lek 2024, 70(8):E11-E14 | DOI: 10.36290/vnl.2024.104

Album-in & Album-out - a look behind the curtain of new recommendations

Jiří Müller, Martin Matějovič
I. interní klinika Lékařské fakulty UK a FN Plzeň

Although synthetic colloids have fallen out of favour in the current evidence-based medicine, the use of albumin remains a common clinical practice. The rationale behind the utilisation of this colloid solution is to increase intravascular volume, facilitate fluid removal, and to treat complications of liver cirrhosis. Nevertheless, the apparently uncontroversial clinical use based on physiological principles is in fact not supported by any robust evidence. Consequently, the 2024 ICTM (International Collaboration for Transfusion Medicine) guidelines recommends albumin administration solely in a very specific subset of patients and notably, even in this limited population, the evidence supporting its use remains inconclusive.

Keywords: albumin, fluid therapy, hypoalbuminemia, sepsis, cirrhosis, colloid solutions, shock, critically ill patient, malnutrition.

Accepted: December 13, 2024; Published: December 18, 2024  Show citation

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Müller J, Matějovič M. Album-in & Album-out - a look behind the curtain of new recommendations. Vnitr Lek. 2024;70(8):E11-14. doi: 10.36290/vnl.2024.104.
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