Vnitr Lek 2024, 70(8):508-512 | DOI: 10.36290/vnl.2024.097

Febrility in malignant disease

Štefan Sotak

I. interná klinika UN LP a UPJŠ LF v Košiciach

Fevers have many causes. The most common is infection. They can also occur in oncological diseases. Fevers caused directly by malignancy are called paraneoplastic. Their diagnosis can sometimes be very complex and lengthy and represents a therapeutic challenge even for an experienced physician; therefore they represent a non-negligible percentage of fevers of unknown origin. The so-called can be helpful naproxen test. Levels of inflammatory parameters can sometimes be misleading - they can be significantly elevated in active malignancy. In addition, febrility in an oncology patient can also occur due to infection, which arises as a result of malignant cachexia or febrile neutropenia, which arises as an adverse effect of chemotherapy, further iatrogenically (after radiation or after the administration of chemotherapeutic drugs), when the central nervous system is affected by primary malignancy or metastases, as part of an adrenal crisis during glucocorticoid treatment or after transfusion.

Keywords: febrility, neoplastic febrility, naproxen.

Accepted: November 27, 2024; Published: December 18, 2024  Show citation