Vnitr Lek 2021, 67(5):e03-e08 | DOI: 10.36290/vnl.2021.080

Whipple disease - systemic disease with gastrointestinal manifestations

Leoš Chrudimský
Patologicko-anatomické oddělení, Nemocnice Jihlava, p. o.

Whipple disease is rare, potentionally life-threatening disease with broad scale of possible symptoms and therefore wide differential diagnosis. Localized forms as well as systemic manifestations are possible. Etiological agent is bacteria Tropheryma whipplei. The most common manifestations include arthralgias, fever, diarrhea, abdominal pain, malabsorption syndrome and weight loss. In my article I present literature review and a case report of the pacient with relatively typical course of the disease.

Keywords: intermitent fever, malabsorption syndrome, PAS positive macrophages, seronegative arthritis, Tropheryma whipplei, Whipple disease.

Published: August 25, 2021  Show citation

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Chrudimský L. Whipple disease - systemic disease with gastrointestinal manifestations. Vnitr Lek. 2021;67(5):e03-08. doi: 10.36290/vnl.2021.080.
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