Vnitr Lek 2021, 67(1):e43-e48 | DOI: 10.36290/vnl.2021.016
Nutritional support in the early stage of critical illness - focused on energy and protein intake
- 1 Klinika anesteziologie, resuscitace a intenzivní medicíny LF OU a FN Ostrava
- 2 Katedra intenzivní medicíny, urgentní medicíny a forenzních oborů LF OU Ostrava
- 3 Klinika dětské anesteziologie a resuscitace, LF MU a FN Brno
- 4 Fyziologický ústav LF MU Brno
- 5 Chirurgické oddělení, Nemocnice Vyškov
- 6 Oddelenie anesteziológie a intenzívnej medicíny, Nemocnica Humenné, Slovensko
The aim of this article is to emphasize the importance of taking into account the mechanism of host's response to insult when choosing a nutritional strategy in the early phase of a critical illness. At the same time, the article discusses the risks associated with early aggressive nutritional intervention for both energy and protein intake. Today, it seems that the most optimal choice of nutritional support during the first week of stay in the ICU is a gradual increase in both energy and protein intake. In numerical terms, this means a daily increase in energy dose of approximately 5 kcal/kg/day and a daily increase in protein dose of 0.2 g /kg/day. However, this only applies to patients admitted to the ICU with a normal body mass index, i.e. without malnutrition or without obesity. Both of these categories require special attention beyond the scope of this article.
Keywords: critically ill, nutritional support, hibernation, autophagy, overfeeding.
Published: March 2, 2021 Show citation
References
- Ronco C, Ricci Z, Husain‑Syed F. From Multiple Organ Support Therapy to Extracorporeal Organ Support in Critically Ill Patients. Blood Purif. 2019; 48(2): 99-105. doi:10.1159/000490694
Go to original source...
Go to PubMed...
- Casaer MP, Mesotten D, Hermans G et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011; 365(6): 506-517. doi:10.1056/NEJMoa1102662.
Go to original source...
Go to PubMed...
- Fivez T, Kerklaan D, Mesotten D et al. Early versus Late Parenteral Nutrition in Critically Ill Children. N Engl J Med. 2016; 374(12): 1111-1122. doi:10.1056/NEJMoa1514762.
Go to original source...
Go to PubMed...
- Wischmeyer PE. Tailoring nutrition therapy to illness and recovery. Crit Care. 2017;21(Suppl 3):316. doi:10.1186/s13054-017-1906-8.
Go to original source...
Go to PubMed...
- Wischmeyer PE. Are we creating survivors…or victims in critical care? Delivering targeted nutrition to improve outcomes. Curr Opin Crit Care. 2016; 22(4): 279-284. doi:10.1097/MCC.0000000000000332.
Go to original source...
Go to PubMed...
- Rawal G, Yadav S, Kumar R. Post‑intensive Care Syndrome: an Overview. J Transl Int Med. 2017; 5(2): 90-92. doi:10.1515/jtim-2016-0016
Go to original source...
Go to PubMed...
- Casaer MP, Van den Berghe G, Gunst J. New ESPEN Guidelines for Nutrition in the Critically Ill: Help, What Happened!? ICU Management & Practice 2019, 19: 140-144
- Hippocrates: The Aphorisms of Hippocrates. New York: The Classics of Medicine Library; 1982.
- Kula R, Chylek V, Szturz P et al. A response to infection in patients with severe sepsis--do we need a "stage‑directed therapy concept"?. Bratisl Lek Listy. 2009;110(8):459-464.
Go to PubMed...
- Singer M, De Santis V, Vitale D, Jeffcoate W. Multiorgan failure is an adaptive, endocrine‑mediated, metabolic response to overwhelming systemic inflammation. Lancet. 2004; 364(9433): 545-548. doi:10.1016/S0140-6736(04)16815-3
Go to original source...
Go to PubMed...
- Mongardon N, Dyson A, Singer M. Is MOF an outcome parameter or a transient, adaptive state in critical illness?. Curr Opin Crit Care. 2009; 15(5): 431-436. doi:10.1097/MCC.0b013e3283307a3b.
Go to original source...
Go to PubMed...
- Stanzani G, Tidswell R, Singer M. Do critical care patients hibernate? Theoretical support for less is more. Intensive Care Med. 2019;10.1007/s00134-019-05813-9. doi:10.1007/s00134-019-05813-9
Go to original source...
Go to PubMed...
- Singer M, Glynne P. Treating critical illness: the importance of first doing no harm. PLoS Med. 2005; 2(6): e167. doi:10.1371/journal.pmed.0020167.
Go to original source...
Go to PubMed...
- Kapadia FN, Kapoor R, Trivedi M. Can Less be More in Intensive Care?. Indian J Crit Care Med. 2017; 21(1): 1-5. doi:10.4103/0972-5229.198308.
Go to original source...
Go to PubMed...
- Uehara M, Plank LD, Hill GL. Components of energy expenditure in patients with severe sepsis and major trauma: a basis for clinical care. Crit Care Med. 1999; 27(7): 1295-1302. doi:10.1097/00003246-199907000-00015.
Go to original source...
Go to PubMed...
- Kreymann G, Grosser S, Buggisch P, Gottschall C, Matthaei S, Greten H. Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock. Crit Care Med. 1993; 21(7): 1012-1019. doi:10.1097/00003246-199307000-00015.
Go to original source...
Go to PubMed...
- Puthucheary ZA, Rawal J, McPhail M, et al. Acute skeletal muscle wasting in critical illness [published correction appears in JAMA. 2014;311(6):625. Padhke, Rahul [corrected to Phadke, Rahul]]. JAMA. 2013; 310(15): 1591-1600. doi:10.1001/jama.2013.278481.
Go to original source...
Go to PubMed...
- Cerra FB, Siegel JH, Coleman B, Border JR, McMenamy RR. Septic autocannibalism. A failure of exogenous nutritional support. Ann Surg. 1980; 192(4): 570-580. doi:10.1097/00000658-198010000-00015.
Go to original source...
Go to PubMed...
- Hartl WH, Jauch KW. Metabolic self‑destruction in critically ill patients: origins, mechanisms and therapeutic principles. Nutrition. 2014; 30(3): 261-267. doi:10.1016/j.nut.2013. 07. 019.
Go to original source...
Go to PubMed...
- Losser MR, Damoisel C, Payen D. Bench‑to‑bedside review: Glucose and stress conditions in the intensive care unit. Crit Care. 2010; 14(4):231. doi:10.1186/cc9100.
Go to original source...
Go to PubMed...
- Losser MR, Bernard C, Beaudeux JL, Pison C, Payen D. Glucose modulates hemodynamic, metabolic, and inflammatory responses to lipopolysaccharide in rabbits. J Appl Physiol (1985). 1997; 83(5): 1566-1574. doi:10.1152/jappl.1997. 83. 5.1566.
Go to original source...
Go to PubMed...
- Marik PE, Bellomo R. Stress hyperglycemia: an essential survival response!. Crit Care. 2013;17(2):305. doi:10.1186/cc12514.
Go to original source...
Go to PubMed...
- Elke G, van Zanten AR, Lemieux M et al. Enteral versus parenteral nutrition in critically ill patients: an updated systematic review and meta‑analysis of randomized controlled trials. Crit Care. 2016; 20(1): 117. doi:10.1186/s13054-016-1298-1.
Go to original source...
Go to PubMed...
- Peterson SJ, Lateef OB, Freels S, McKeever L, Fantuzzi G, Braunschweig CA. Early Exposure to Recommended Calorie Delivery in the Intensive Care Unit Is Associated With Increased Mortality in Patients With Acute Respiratory Distress Syndrome. JPEN J Parenter Enteral Nutr. 2018; 42(4): 739-747. doi:10.1177/0148607117713483.
Go to original source...
Go to PubMed...
- Arabi YM, Tamim HM, Dhar GS et al. Permissive underfeeding and intensive insulin therapy in critically ill patients: a randomized controlled trial. Am J Clin Nutr. 2011; 93(3): 569-577. doi:10.3945/ajcn.110.005074.
Go to original source...
Go to PubMed...
- Zusman O, Theilla M, Cohen J, Kagan I, Bendavid I, Singer P. Resting energy expenditure, calorie and protein consumption in critically ill patients: a retrospective cohort study. Crit Care. 2016; 20(1): 367. doi:10.1186/s13054-016-1538-4.
Go to original source...
Go to PubMed...
- Oshima T, Deutz NE, Doig G, Wischmeyer PE, Pichard C. Protein‑energy nutrition in the ICU is the power couple: A hypothesis forming analysis. Clin Nutr. 2016; 35(4): 968-974. doi:10.1016/j.clnu.2015. 10. 016.
Go to original source...
Go to PubMed...
- Al‑Dorzi HM, Albarrak A, Ferwana M, Murad MH, Arabi YM. Lower versus higher dose of enteral caloric intake in adult critically ill patients: a systematic review and meta‑analysis. Crit Care. 2016; 20(1): 358. doi:10.1186/s13054-016-1539-3.
Go to original source...
Go to PubMed...
- Gunst J, Van den Berghe G. Intensive Care Nutrition and Post‑Intensive Care Recovery. Crit Care Clin. 2018; 34(4): 573-583. doi:10.1016/j.ccc.2018. 06. 004.
Go to original source...
Go to PubMed...
- Gunst J. Recovery from critical illness‑induced organ failure: the role of autophagy. Crit Care. 2017; 21(1): 209. doi:10.1186/s13054-017-1786-y.
Go to original source...
Go to PubMed...
- https://www.nobelprize.org/prizes/medicine/2016/press‑release/.
- de Cabo R, Mattson MP. Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med. 2019; 381(26): 2541-2551. doi:10.1056/NEJMra1905136.
Go to original source...
Go to PubMed...
- Gunst J., Vanhorebeek I, Van den Berghe G. The role of autophagy in recovery from critical illness. ICU Management & Practice 2017; 17: 134-136.
- Kroemer G, Mariño G, Levine B. Autophagy and the integrated stress response. Mol Cell. 2010; 40(2): 280-293. doi:10.1016/j.molcel.2010. 09. 023.
Go to original source...
Go to PubMed...
- Watanabe E, Muenzer JT, Hawkins WG et al. Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory‑based study. Lab Invest. 2009;89(5):549-561. doi:10.1038/labinvest.2009.8.
Go to original source...
Go to PubMed...
- Vanhorebeek I, Gunst J, Derde S et al. Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients. J Clin Endocrinol Metab. 2011; 96(4): E633-E645. doi:10.1210/jc.2010-2563.
Go to original source...
Go to PubMed...
- Hermans G, Casaer MP, Clerckx B et al. Effect of tolerating macronutrient deficit on the development of intensive‑care unit acquired weakness: a subanalysis of the EPaNIC trial. Lancet Respir Med. 2013; 1(8): 621-629. doi:10.1016/S2213-2600(13)70183-8.
Go to original source...
Go to PubMed...
- Casaer MP, Mesoltten D. Nutritional Failure: An Adaptive Response to Critical Illness? ICU Management & Practice 2013, 13: 98-101.
- Arabi YM, Al‑Dorzi HM, Sadat M. Protein intake and outcome in critically ill patients. Curr Opin Clin Nutr Metab Care. 2020; 23(1): 51-58. doi:10.1097/MCO.0000000000000619.
Go to original source...
Go to PubMed...
- Hoffer LJ. Protein requirement in critical illness. Appl Physiol Nutr Metab. 2016; 41(5): 573-576. doi:10.1139/apnm-2015-0551.
Go to original source...
Go to PubMed...
- Rooyackers O, Sundström Rehal M, Liebau F, Norberg Å, Wernerman J. High protein intake without concerns?. Crit Care. 2017;21(1):106. doi:10.1186/s13054-017-1699-9.
Go to original source...
Go to PubMed...
- Casaer MP, Wilmer A, Hermans G, Wouters PJ, Mesotten D, Van den Berghe G. Role of disease and macronutrient dose in the randomized controlled EPaNIC trial: a post hoc analysis. Am J Respir Crit Care Med. 2013;187(3):247-255. doi:10.1164/rccm.201206-0999OC.
Go to original source...
Go to PubMed...
- Koekkoek WACK, van Setten CHC, Olthof LE, Kars JCNH, van Zanten ARH. Timing of PROTein INtake and clinical outcomes of adult critically ill patients on prolonged mechanical VENTilation: The PROTINVENT retrospective study. Clin Nutr. 2019; 38(2): 883-890. doi:10.1016/j.clnu.2018. 02. 012.
Go to original source...
Go to PubMed...
- de Koning MLY, Koekkoek WACK, Kars JCNH, van Zanten ARH. Association of PROtein and CAloric Intake and Clinical Outcomes in Adult SEPTic and Non‑Septic ICU Patients on Prolonged Mechanical Ventilation: The PROCASEPT Retrospective Study. JPEN J Parenter Enteral Nutr. 2020; 44(3): 434-443. doi:10.1002/jpen.1663.
Go to original source...
Go to PubMed...
- Preiser JC, Wernerman J. Provision of Nutrients to the Acutely Ill. Introducing the "Baby Stomach" Concept. Am J Respir Crit Care Med. 2017; 196(9): 1089-1090. doi:10.1164/rccm.201705-0919ED.
Go to original source...
Go to PubMed...
- Koekkoek KWAC, van Zanten ARH. Nutrition in the ICU: new trends versus old‑fashioned standard enteral feeding?. Curr Opin Anaesthesiol. 2018; 31(2): 136-143. doi:10.1097/ACO.0000000000000571.
Go to original source...
Go to PubMed...
- Heyland DK, Stapleton R, Compher C. Should We Prescribe More Protein to Critically Ill Patients?. Nutrients. 2018;10(4):462. doi:10.3390/nu10040462.
Go to original source...
Go to PubMed...
- Preiser JC. High protein intake during the early phase of critical illness: yes or no?. Crit Care. 2018; 22(1): 261. doi:10.1186/s13054-018-2196-5.
Go to original source...
Go to PubMed...
- De Waele E, Malbrain MLNG, Spapen H. Nutrition in Sepsis: A Bench‑to‑Bedside Review. Nutrients. 2020; 12(2): 395. Published 2020 Feb 2. doi:10.3390/nu12020395.
Go to original source...
Go to PubMed...
- Greig PD, Elwyn DH, Askanazi J, Kinney JM. Parenteral nutrition in septic patients: effect of increasing nitrogen intake. Am J Clin Nutr. 1987; 46(6): 1040-1047. doi:10.1093/ajcn/46. 6. 1040.
Go to original source...
- Thiessen SE, Derde S, Derese I et al. Role of Glucagon in Catabolism and Muscle Wasting of Critical Illness and Modulation by Nutrition. Am J Respir Crit Care Med. 2017; 196(9): 1131-1143. doi:10.1164/rccm.201702-0354OC.
Go to original source...
Go to PubMed...
- Meijer AJ. Amino acid regulation of autophagosome formation. Methods Mol Biol. 2008;445:89-109. doi:10.1007/978-1-59745-157-4_5.
Go to original source...
Go to PubMed...
- NICE‑SUGAR Study Investigators, Finfer S, Chittock DR, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009; 360(13): 1283-1297. doi:10.1056/NEJMoa0810625.
Go to original source...
Go to PubMed...
- AVERT Trial Collaboration group. Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial. Lancet. 2015; 386(9988): 46-55. doi:10.1016/S0140-6736(15)60690-0.
Go to original source...
Go to PubMed...
- Rist VT, Weiss E, Eklund M, Mosenthin R. Impact of dietary protein on microbiota composition and activity in the gastrointestinal tract of piglets in relation to gut health: a review. Animal. 2013;7(7):1067-1078. doi:10.1017/S1751731113000062.
Go to original source...
Go to PubMed...
- http://main.poliquingroup.com/ArticlesMultimedia/Articles/Article/2646/Three_Situations_In_Which_A_High‑Protein_Diet_Is_A_Bad_Idea.aspx.