Vnitr Lek 2019, 65(4):303-306 | DOI: 10.36290/vnl.2019.053

Ethanol and risk of hypoglycemia in patients with type 1 diabetes mellitus: a brief overview for clinical practice

Martina Tuháčková1, Jana Urbanová2, Ludmila Brunerová2, Pavlína Piťhová1, Milan Kvapil1, Jan Brož1,*
1 Interní klinika 2. LF UK a FN Motol, Praha
2 Centrum pro výzkum diabetu, metabolismu a výživy, II. interní klinika 3. LF UK a FN Královské Vinohrady, Praha

Alcoholic drinks are one of the risk factors for hypoglycemia. Ethanol inhibits gluconeogenesis, decreases a level of growth hormone and impairs hypoglycemia awareness. The risk of hypoglycemia while drinking alcohol can be reduced by parallel ingestion of food (saccharides). Some recommendations also mention the change of insulin doses.

Keywords: alcohol; ethanol; hepatic gluconeogenesis; hypoglycemia

Received: September 18, 2018; Accepted: January 31, 2019; Published: April 1, 2019  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Tuháčková M, Urbanová J, Brunerová L, Piťhová P, Kvapil M, Brož J. Ethanol and risk of hypoglycemia in patients with type 1 diabetes mellitus: a brief overview for clinical practice. Vnitr Lek. 2019;65(4):303-306. doi: 10.36290/vnl.2019.053.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Burton R, Sheron N No level of alcohol consumption improves health. Lancet 2018; 392(10152): 987-988. Dostupné z DOI: <http://dx.doi.org/10.1016/S0140-6736(18)31571-X>. Go to original source... Go to PubMed...
    2. McCoy RG, Van Houten HK, Ziegenfuss JY et al. Increased mortality of patients with diabetes reporting severe hypoglycemia. Diabetes Care 2012; 35(9): 1897-1901. Dostupné z DOI: <http://dx.doi.org/10.2337/dc11-2054>. Go to original source... Go to PubMed...
    3. Hemmingsen B, Lund SS, Gluud C et al. Intensive glycaemic control for patients with type 2 diabetes: systematic review with meta-analysis and trial sequential analysis of randomised clinical trials. BMJ 2011; 343: d6898. Dostupné z DOI: <http://dx.doi.org/10.1136/bmj.d6898>. Go to original source... Go to PubMed...
    4. Bolek T, Samoš M, Mokáň M et al. Akútne príčiny náhlych úmrtí u pacientov so závažnou hypoglykémiou. Vnitř Lék 2016; 62(6): 462-466. Go to PubMed...
    5. Brož J, Piťhová P, Janíčková Žďárská D. Syndrom porušeného vnímání hypoglykemie u diabetes mellitus. Vnitř Lék 2016; 62(7-8): 544-547.
    6. Tetzscher R, Norgaard K, Ranjan A. Effects of alcohol on plasma glucose and prevention of alcohol-induced hypoglycemia in type 1 diabetes-A systematic review with GRADE. Diabetes Metab Res Rev. 2018;34(3). Dostupné z DOI: <http://dx.doi.org/10.1002/dmrr.2965>. Go to original source... Go to PubMed...
    7. Ahmed AT, Karter AJ, Liu J. Alcohol consumption is inversely associated with adherence to diabetes self-care behaviours. Diabet Med 2006; 23(7): 795-802. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1464-5491.2006.01878.x>. Go to original source... Go to PubMed...
    8. Blomster JI, Zoungas S, Chalmers J et al. The relationship between alcohol consumption and vascular complications and mortality in individuals with type 2 diabetes mellitus. Diabetes Care 2014; 37(9): 1353-1359. Dostupné z DOI: <http://dx.doi.org/10.2337/dc13-2727>. Erratum in Erratum. The Relationship Between Alcohol Consumption and Vascular Complications and Mortality in Individuals With Type 2 Diabetes. Diabetes Care 2014; 37: 1353-1359. [Diabetes Care 2015]. Go to original source... Go to PubMed...
    9. Baliunas DO, Taylor BJ, Irving H et al. Alcohol as a risk factor for type 2 diabetes: a systematic review and metaanalysis. Diabetes Care 2009; 32(11): 2123-2132. Dostupné z DOI: <http://dx.doi.org/10.2337/dc09-0227>. Go to original source... Go to PubMed...
    10. Koppes LL, Dekker JM, Hendriks HF et al. Moderate alcohol consumption lowers the risk of type 2 diabetes: a metaanalysis of prospective observational studies. Diabetes Care 2005; 28(3): 719-725. Go to original source... Go to PubMed...
    11. Jakobsen ML, Larsen JR, Glümer C et al. Alcohol consumption among patients with diabetes: a survey-based cross-sectional study of Danish adults with diabetes. Scand J Public Health 2016; 44(5): 517-524. Dostupné z DOI: <http://dx.doi.org/10.1177/1403494816645223>. Go to original source... Go to PubMed...
    12. Boffetta P, Garfinkel L. Alcohol drinking and mortality among men enrolled in an american Cancer Society prospective study. Epidemiology 1990; 1(5): 342-348. Go to original source... Go to PubMed...
    13. Friedman L, Kimball W. Coronary heart disease mortality and alcohol consumption in Framingham. Am J Epidemiol 1986; 124(3): 481-489. Go to original source... Go to PubMed...
    14. Pedersen-Bjergaard U, Reubsaet JLE, Nielsen SL et al. Psychoactive drugs, alcohol, and severe hypoglycemia in insulin-treated diabetes: Analysis of 141 cases. Am J Med 2005; 118(3): 307-310. Go to original source... Go to PubMed...
    15. Sabitha Kandi, Neelesh Deshpande, Pragna Rao et al. Alcoholism and Its Relation to Hypoglycemia - An Overview. Asian Journal of Medical Sciences (Asian J Med Sci) 2014; 2(3): 64-66. Dostupné z DOI: Dostupné z DOI: <http://dx.doi.org/10.12691/ajmsm-2-3-3>. Go to original source...
    16. De Feo P, Perriello G, Torlone E et al. Demonstration of a role for growth hormone in glucose counterregulation. Am J Physiol 1989; 256(6 Pt 1): E835-E843. Dostupné z DOI: <http://dx.doi.org/10.1152/ajpendo.1989.256.6.E835>. Go to original source... Go to PubMed...
    17. Turner BC, Jenkins E, Kerr D et al. The effect of evening alcohol consumption on next-morning glucose control in Type 1 diabetes. Diabetes Care 2001; 24(11): 1888-1893. Go to original source... Go to PubMed...
    18. Kerr D, Cheyne E, Thomas P et al. Influence of acute alcohol ingestion on the hormonal responses to modest hypoglycaemia in patients with Type 1 diabetes. Diabet Med 2007; 24(3): 312-316. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1464-5491.2006.02054.x>. Go to original source... Go to PubMed...
    19. Avogaro A, Beltramello P, Gnudi L et al. Alcohol intake impairs glucose conuterregulation during acute insulin-induced hypoglycemia in IDDM patients. Evidence for a critical role of free fatty acids. Diabetes 1993; 42(11): 1626-1634. Go to original source...
    20. Kerr D, Macdonald IA, Heller SR et al. Alcohol causes hypoglycaemic unawareness in healthy volunteers and patients with Type 1 (insulin-dependent) diabetes. Diabetologia 1990; 33(4): 216-221. Go to original source... Go to PubMed...
    21. Cheyne EH, Sherwin RS, Lunt MJ et al. Influence of alcohol on cognitive performance during mild hypoglycaemia; implications for Type 1 diabetes. Diabet Med 2004; 21(3): 230-237. Go to original source... Go to PubMed...
    22. Arky AR, Freinkel N. Alcohol Hypoglycemia. Effects of ethanol on plasma. 3. glucose, ketones, and free fatty acids in "juvenile" diabetics: a model for "nonketotic diabetic acidosis"? Arch Intern Med 1964; 114: 501-507. Go to original source... Go to PubMed...
    23. Lange J, Arends J, Willms B. Alcohol-induced hypoglycemia in type 1 diabetic patients. Med Klin (Munich). 1991; 86(11): 551-554. Go to PubMed...
    24. Richardson T, Weiss M, Thomas P et al. Day After the Night before: influence of evening alcohol on risk of hypoglycemia in patients with type 1 diabetes. Diabetes Care 2005; 28(7): 1801-1802. Go to original source... Go to PubMed...
    25. Murad MH, Coto-Yglesias F, Wang AT et al. Clinical review: Drug-induced hypoglycemia: a systematic review. J Clin Endocrinol Metab 2009; 94(3): 741-745. Dostupné z DOI: <http://dx.doi.org/10.1210/jc.2008-1416>. Go to original source... Go to PubMed...
    26. Koivisto AV, Tulokas S, Toivonen M et al. Alcohol With a Meal Has No Adverse Effect on Postprandial Glucose Homeostasis in Diabetic Patients. Diabetes Care 1993; 16(12): 1612-1614. Go to original source... Go to PubMed...
    27. Plougmann S, Hejlesen O, Turner B et al. Modelling the effect of alcohol in Type 1 diabetes. Stud Health Technol Inform 2002; 90: 66-71. Go to PubMed...
    28. Saunders B. Sometimes you've just got to have fun, haven't you?': The discursive construction of social drinking practices in young adults' accounts of chronic illness. Commun Med 2011; 8(1): 77-87. Go to original source... Go to PubMed...
    29. Kanny D, Liu Y, Brewer RD et al. Vital signs: binge drinking prevalence, frequency, and intensity among adults - United States, 2010. MMWR Morb Mortal Wkly Rep 2012; 61(01): 14-19.
    30. Ismail D, Gebert R, Vuillermin PJ et al. Social consumption of alcohol in adolescents with Type 1 diabetes is associated with increased glucose lability, but not hypoglycaemia. Diabet Med 2006; 23(8): 830-833. Dostupné z DOI: <http://dx.doi.org/10.1111/j.1464-5491.2006.01868.x>. Go to original source... Go to PubMed...

    Return to the content


    Vnitřní lékařství

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.