Vnitr Lek 2017, 63(1):43-48 | DOI: 10.36290/vnl.2017.008

ScreenPro FH - Screening Project for Familial Hypercholesterolemia in Central, Southern and Eastern Europe: Rationale and Design

Richard Češka¹, György Paragh^2,*, Željko Reiner³, Maciej Banach⁴, Lale Tokgözoğlu⁵, Andrey V. Susekov⁶, Katarína Rašlová⁷, Tomáš Freiberger^8,9, Branislav Vohnout^7,10, Andrzej Rynkiewicz¹¹, Assen Goudev¹², Gheorghe-Andrei Dan¹³, Dan Gaiţă¹⁴, Belma Pojskić¹⁵, Ivan Pećin³, Meral Kayikçioğlu¹⁶, Olena Mitchenko¹⁷, Marat V. Ezhov¹⁸, Gustavs Latkovskis¹⁹, Žaneta Petrulionienė²⁰, Zlatko Fras²¹, Nebojsa Tasić²², Erkin M. Mirrakhimov²³, Tolkun Murataliev²³, Alexander B. Shek²⁴, Vladimír Tuka¹, Alexandros D. Tselepis²⁵, Elie M. Moubarak²⁶, Khalid Al Rasadi²⁷

¹ Third Department of Medicine - Department of Endocrinology and Metabolism of the First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

² Institute of Internal Medicine, University of Debrecen Faculty of Medicine, Debrecen, Hungary

³ Department of Internal Medicine, Division of Metabolic Diseases, School of Medicine University of Zagreb, University Hospital Centre Zagreb, Zagreb, Croatia

⁴ Department of Hypertension, Medical University of Lodz, Lodz, Poland

⁵ Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey

⁶ Department of clinical Pharmacology and therapeutics, Academy for Postgraduate Education, Ministry of Health, Russian Federation

⁷ Coordination Centre for Familial Hyperlipidemias, Slovak Medical University, Bratislava, Slovakia

⁸ Molecular Genetics Lab, Centre for Cardiovascular Surgery and Transplantation, Brno, Czech Republic

⁹ Medical Faculty, Masaryk University, Brno, Czech Republic

¹⁰ Institute of Nutrition, FOaZOS, Slovak Medical University, Bratislava, Slovakia

¹¹ Department of Cardiology and Cardiosurgery, Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland

¹² Queen Giovanna University Hospital, Sofia, Bulgaria

¹³ University of Medicine Carol Davila, Colentina University Hospital, Bucharest, Romania

¹⁴ University of Medicine & Pharmacy Victor Babes, Institute of Cardiovascular Diseases, CardioPrevent Foundation Timisoara, Romania

¹⁵ Cantonal hospital, Zenica, Bosnia and Herzegovina

¹⁶ Cardiology Department, Ege University Medical School, Lipid Clinic, Izmir, Turkey

¹⁷ Institute of Cardiology, AMS Ukraine Dyslipidemia Department, Kiev, Ukraine

¹⁸ Russian Cardiology Research and Production Centre, Moscow, Russian Federation

¹⁹ Latvian Institute of Cardiology and Regenerative Medicine, Faculty of Medicine, University of Latvia; Paul Stradins Clinical University Hospital, Riga, Latvia

²⁰ Centre of Cardiology and Angiology, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania

²¹ Division of Internal Medicine, Preventive Cardiology Unit and Medical Faculty, University of Ljubljana, University Medical Centre, Ljubljana, Slovenia

²² Cardiovascular Research Centre, Cardiovascular Institute "Dedinje", Belgrade, Serbia

²³ National Centre of Cardiology and Therapy named after academician Mirsaid Mirrakhimov, Kyrgyz State Medical Academy naved after I. K. Akhunbaev, Bishkek, Kyrgyzstan

²⁴ Republican Specialized Centre of Cardiology, Tashkent, Uzbekistan

²⁵ Department of Chemistry, University of Ioannina, Atherothrombosis Research Centre, Ioannina, Greece

²⁶ LDL apheresis Centre, Dahr El Bachek Government University Hospital - DGUH, Roumieh - Lebanon

²⁷ College of Medicine and Health Science at Sultan Qaboos University, Sultan Qaboos University Hospital, Muscat, Oman

Familial hypercholesterolemia (FH) is a genetic disorder with well-known genetic transmission and clinical course. Despite great recent progress, FH is still underestimated, under-diagnosed and thus undertreated. Furthermore it represents a significant healthcare challenge as a common risk factor for the premature development of coronary heart disease. The ScreenPro FH Project is an international network project aiming at improving complex care - from timely screening, through diagnosis to up-to-date treatment of familial hypercholesterolemia in Central, Eastern and Southern Europe. An important task for the project is to harmonise and unify diagnostic and therapeutic approaches in participating countries, where the situation differs from country to country. Countries with more experience should serve as a model for countries developing the FH network.

Keywords: diagnosis; familial hypercholesterolemia; screening; treatment optimization

Received: December 22, 2016; Published: January 1, 2017  Show citation