Vnitr Lek 2016, 62(10):814-819
Rivaroxaban use in prevention of stroke in patients with non-valvular atrial fibrillation in clinical practice, results of observational studies and our experience
- Kardiovaskulární centrum Nemocnice Na Homolce, Praha
Rivaroxaban is direct oral factor Xa inhibitor indicated for tromboembolic event rate reduction in patients with non-valvular atrial fibrillation. Knowledge of rivaroxaban efficacy and safety comes from a phase III randomized clinical trial ROCKET AF. In the present, we have more evidence of rivaroxaban efficacy from real-life clinical studies. XANTUS study was first international prospective observational real-life study documenting use of rivaroxaban in stroke prevention in a broad population of patients with non-valvular atrial fibrillation. The incidence of major bleeding and tromboembolic events was in real clinical practice low. RELIEF study was a second important study describing use of rivaroxaban in real-life clinical practice. The aim of this rectrospective study was to compare effectiveness of newly indicated rivaroxaban treatment with the vitamin K antagonists treatment. Our experience shows low incidence of bleeding with this therapy too.
Keywords: anticoagulation therapy; non-valvular atrial fibrillation; real-life studies; rivaroxaban
Received: March 10, 2016; Accepted: August 16, 2016; Published: October 1, 2016 Show citation
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