Vnitr Lek 2016, 62(1):57-61

Dangerous cucumbers - Leyll's syndrome

Ján Csomor^1,*, Bohuš Bunganič¹, Sergey Zakharov², Igor Pafčuga³, Pavel Sedloň¹, Petr Urbánek¹

¹ Interní klinika 1. LF UK a Ústřední vojenská nemocnice - Vojenská fakultní nemocnice Praha

² Toxikologické informační středisko Kliniky pracovního lékařství 1. LF UK a VFN Praha

³ Klinika popáleninové medicíny 3. LF UK a FN Královské Vinohrady Praha

Leyll's syndrome (syndrome of toxic epidermal necrolysis) is a rare disease, firstly described by Scottish doctor of medicine Allan Lyell in 1956. It is characterized by huge skin and mucosa necrolysis, which affects at least 30 % of body surface, and systemic symptoms. According to the frequency of the occurrence it is an extremely rare condition, with an incidence of 0.5-2 cases per million residents per year. Leyll's syndrome is considered as a toxoallergic reaction, triggered mostly by some medication and it is associated with a very high mortality rate (in the literature reported between 30 to 90 %). Adequate and timely local and systemic treatment at the Intensive Care Unit or at the specialized clinic can improve the overall poor prognosis of the patients. In our case report we describe a very rare case of the Lyell's syndrome after exposure to the antifungal organosulfur compound, which is widely used by the homegardners and farmers.

Keywords: bis-dithiocarbamates; Leyll's syndrome; toxic epidermal necrolysis

Received: June 24, 2015; Accepted: September 23, 2015; Published: January 1, 2016  Show citation