Vnitr Lek 2014, 60(11):958-962
Non-pharmacological treatment - results from Poděbrady
- 1 III. interní klinika 1. LF UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA
- 2 Klinika dětského a dorostového lékařství 1. LF UK a VFN Praha, přednosta prof. MUDr. Jiří Zeman, DrSc.
- 3 Laboratoř molekulární genetiky IKEM Praha, přednosta MUDr. Jan Piťha, CSc.
Objectives:
The study was aimed to determine risk factors of atherosclerosis after one month lifestyle intervention in overweight/obese children and also FTO and MC4R gene variants associated with obesity.
Design and Methods:
350 non-diabetic Czech children (age 13.7 ± 2.1 years, 163 ± 10.6 cm hight) was examined. Before and after 4 weeks of lifestyle intervention (comprising a reduction of energy intake), biochemical and anthropometrical measurements were performed.
Results:
The mean weight loss achieved was 6.2 ± 2.1 kg (P < 0.001). Significant associations between BMI decrease and FTO and MC4R variants were found. Carriers of the FTO GG genotype and/or MC4R CC genotype lost significantly more body weight in comparison to the non-carriers (P < 0.0009 for BMI and P < 0.002 for body weight). The differences remain significant after adjustment for sex age and baseline values (P = 0.004 for BMI and P = 0.01 for body weight).
Conclusions:
It is necessary to look for the risk individuals with wrong response to the regime intervention. This individuals is necessary early treat with drugs to prevention clinically complications.
Keywords: childhood obesity; components of metabolic syndrome; predisposition; response to intervention
Received: August 31, 2014; Accepted: October 1, 2014; Published: November 1, 2014 Show citation
References
- Zlatohlávek L, Urbanová Z, Vrablík M et al. Sledování faktorů aterokslerózy u obézních dětí. Čes-Slov Pediat 2011; 66(3): 153-156.
- Šamánek M, Urbanová Z Výskyt nadváhy a obezity u 7 427 českých dětí vyšetřených v roce 2006. Čes-Slov Pediat 2008; 63(3): 120-126.
- Hubacek JA, Pikhart H, Peasey A et al. FTO variant, energy intake, physical activity and basal metabolic rate in Caucasians. The HAPIEE study. Physiol Res 2011; 60(1): 175-183.
Go to original source... 
Go to PubMed... - Haupt A Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss. Obesity (Silver Spring) 2009; 17(10): 1942-1945.
- Loos RJ, Lindgren CM, Li S et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40(6): 768-765. Go to original source... Go to PubMed...
- Hubacek JA, Pitha J, Adamkova V et al. A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females. Czech post-MONICA and 3PMFs studies. Clin Chem Lab Med 2009; 47(4): 387-390. Go to original source... Go to PubMed...
- Dlouhá D, Suchánek P, Lánská V et al. Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms. Physiol Res 2011; 60(1): 199-202. Go to original source... Go to PubMed...