Vnitr Lek 2013, 59(10):903-908

The current approach to the treatment of the patients with metastatic colorectal cancer

J. Halámková^1,2,*, J. Tomášek¹, S. Rybníčková³, D. Adámková Krákorová¹, B. Bencsiková¹, I. Kiss¹

¹ Klinika komplexní onkologické péče Lékařské fakulty MU a MOÚ Brno, přednosta prof. MUDr. Rostislav Vyzula, CSc.

² Ústav lékařské etiky Lékařské fakulty MU Brno, přednosta doc. Mgr. Josef Kuře, Dr. phil.

³ Oddělení radiologie Masarykova onkologického ústavu Brno, přednostka prim. MUDr. Helena Bartoňková

Colorectal cancer is one of the most common malignant tumors. Despite the constant promotion of prevention remains around 20-30% of cases diagnosed in the metastatic stage and approximately 50-60% of patients developed the late dissemination. In 80-90% of them we can find already unresectable metastases. Although surgical treatment is basic modality of therapy, with using modern targeted therapy in combination with chemotherapy we can achieve long-term complete remission in the cases of advanced tumor and we can significantly prolonged the life of patients with this disease now. About 40-50% patients in advanced stages who underwent metastasectomy survives 5-years and 10-year survival rate is up to 25%. When administered systemic treatment median overall survival in these cases reaches around 24 months.

Keywords: colorectal cancer; liver metastases; conversion therapy; targeted treatment

Received: April 15, 2013; Accepted: June 6, 2013; Published: October 1, 2013  Show citation