Vnitr Lek 2013, 59(4):313-316

Case history acquired haemophilia A

Z. Čermáková1,*, R. Hrdličková2, Š. Blahutová2, A. Ligová3
1 Lékařská fakulta OU Ostrava, děkan doc. MUDr. Jaroslav Horáček, CSc.
2 Krevní centrum FN Ostrava, přednostka prim. MUDr. Zuzana Čermáková, Ph.D.
3 Ústav klinické hematologie Lékařské fakulty OU a FN Ostrava, přednosta prim. MUDr. Jaromír Gumulec

Acquired haemophilia A is a rare form of acquired coagulopathy caused by autoantibodies against coagulation factor VIII. It is characterized by major bleeding complications often life-threatening. An estimated incidence is about 1-2 cases per million inhabitants per year. The authors report case history of acquired haemophilia in 85 year old woman. Bleeding complications were well controled by bypassing agents. Inhibitor eradication was successful after the use of second line agent rituximab.

Keywords: acquired haemophilia A; factor VIII inhibitor; rituximab

Received: October 16, 2012; Accepted: February 12, 2013; Published: April 1, 2013  Show citation

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Čermáková Z, Hrdličková R, Blahutová Š, Ligová A. Case history acquired haemophilia A. Vnitr Lek. 2013;59(4):313-316.
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