Vnitr Lek 2012, 58(4):322-324

Hypergastrinaemia without detection of gastrinoma

Ľ. Cibičková^1,2,*, J. Janková³, Ľ. Víchová⁴

¹ Interní oddělení Nemocnice Hranice, a. s., Hranice, prim. MUDr. Zbyněk Jelínek

² Ústav patologické fyziologie Lékařské fakulty UP Olomouc, přednosta prof. MUDr. Jaroslav Veselý, CSc.

³ Ústav klinické a molekulární patologie Lékařské fakulty UP a FN Olomouc, přednosta prof. MUDr. Zdeněk Kolář, CSc.

⁴ Praktická lékařka pro dorost a dospělé Hranice

We present a case-report of a woman with persisting gastric ulcers, who had elevated gastrin blood levels. First of all, a rare cause of hypergastrinaemia was excluded - a gastrinoma. It was not found despite of extensive investigation. Ulcers were repetitively biopted and transition of high grade dysplasia to adenocarcinoma was detected. Gastrin levels normalised after surgical antrectomia. Afterwards pernicious anaemia was diagnosed as the underlining cause of hypergastrinaemia.

Keywords: gastrin; gastrinoma; pernicious anaemia

Received: November 8, 2011; Accepted: December 25, 2011; Published: April 1, 2012  Show citation