Vnitr Lek 2011, 57(9):684-692

Biological treatment in dermatology - psoriasis

K. Ettler
Klinika nemocí kožních a pohlavních Lékařské fakulty UK a FN Hradec Králové, přednosta doc. MUDr. Karel Ettler, CSc.

Psoriasis is a chronic, relapsing skin disease affecting 1-2% of the population. Genetically-determined autoimmune inflammation is initiated by an infection (e.g. streptococcal). T-lymphocytes, producing a number of cytokines, mainly of the Th1 profile, including TNFα, play a key role. The role of Th17 and its interleukin IL-23 has recently been confirmed. It contains p40 protein, also a component of IL-12. TNFα and p40 blockade appear to be an effective biological treatment of severe lesional psoriasis. Further research and new drug development is to assure modern individualized treatment of psoriasis as well as other skin diseases.

Keywords: biological treatment of psoriasis; TNFα blockers; IL-12, 23 blockers

Received: April 23, 2011; Published: September 1, 2011  Show citation

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Ettler K. Biological treatment in dermatology - psoriasis. Vnitr Lek. 2011;57(9):684-692.
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