Vnitr Lek 2011, 57(5):497-501

The decrease in morbidity and mortality of patients with chronic forms of ischemic heart disease is the result of conservative treatment

L. Kotík
I. interní klinika Fakultní Thomayerovy nemocnice a IPVZ Praha, přednosta prof. MUDr. Štefan Alušík, CSc.

Article presents actual comparison of therapeutic methods for patients with chronic coronary artery disease and their influence on morbidity and mortality. It calls attention to the insufficiently presented fact, that invasive methods, like percutaneous and surgical revascularization, despite great expectations, have not proved to lower morbidity and mortality in large randomized studies. In contrary several groups of drugs proved their efficiency many times. Paradoxically, the cheapest approach, life style intervention, seems to be the most efficient method for prognosis improvement of patients with chronic coronary artery disease.

Keywords: chronic coronary artery disease; invasive and conservative therapy; morbidity and mortality

Received: October 24, 2010; Accepted: January 18, 2011; Published: May 1, 2011  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Kotík L. The decrease in morbidity and mortality of patients with chronic forms of ischemic heart disease is the result of conservative treatment. Vnitr Lek. 2011;57(5):497-501.
Download citation

References

  1. Varnauskas E. Twelve-year follow-up of survival in the randomized European Coronary Surgery Study. N Engl J Med 1988; 319: 332-337. Go to original source... Go to PubMed...
  2. Detre K, Peduzzi P, Murphy M et al. Effect of bypass surgery on survival in patients in low- and high-risk subgroups delineated by the use of simple clinical variables. Circulation 1981; 63: 1329-1338. Go to original source... Go to PubMed...
  3. Aschermann M, Aschermann O. Perkutánní transluminální koronární angioplastika - 30. výročí prvního výkonu. Cor Vasa 2007; 49: 241-242.
  4. The Bypass Angioplasty Revascularization Investigation (BARI) Investigators. Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease. N Engl J Med 1996; 335: 217-225. Go to original source... Go to PubMed...
  5. Agostoni P, Biondi-Zoccai GL, Abbate A et al. Is bare-metal stenting superior to balloon angioplasty for small vessel coronary artery disease? Evidence from a meta-analysis of randomized trials. Eur Heart J 2005; 26: 881-889. Go to original source... Go to PubMed...
  6. Iakovou I, Schmidt T, Bonizzoni E et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA 2005; 293: 2126-2130. Go to original source... Go to PubMed...
  7. Dibra A, Kastrati A, Mehilli J et al. Paclitaxel-eluting or sirolimus-eluting stents to prevent restenosis in diabetic patients. N Engl J Med 2005; 353: 663-670. Go to original source... Go to PubMed...
  8. Boden WE, O'Rourke RA, Teo KK et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med 2007; 356: 1503-1516. Go to original source... Go to PubMed...
  9. Frye RL, August P, Brooks MM et al. BARI 2D Study Group. A randomized trial of therapies for type 2 diabetes and coronary artery disease. N Engl J Med 2009; 360: 2503-2515. Go to original source... Go to PubMed...
  10. Trikalinos TA, Alsheikh-Ali AA, Tatsioni A et al. Percutaneous coronary interventions for non-acute coronary artery disease: a quantitative 20-year synopsis and a network meta-analysis. Lancet 2009; 373: 911-918. Go to original source... Go to PubMed...
  11. Nakamura Y, Moss AJ, Brown MW et al. Long-term nitrate use may be deleterious in ischemic heart disease: a study using the databases from two largescale postinfarction studies. Multicenter Myocardial Ischemia Research Group. Am Heart J 1999; 138: 577-585. Go to original source... Go to PubMed...
  12. Chow CK, Jolly S, Rao-Melacini P et al. Association of diet, exercise, and smoking modification with risk of early cardiovascular events after acute coronary syndromes. Circulation 2010; 121: 750-758. Go to original source... Go to PubMed...
  13. Szwed H, Pachocki R, Domzal-Bochenska M et al. Efficacy and tolerance of trimetazidine in combination with one of the antianginal drugs in patients with stable effort angina. Diagnostyka Leczenie Kardiologii 1997; 4: 237-247.
  14. Di Napoli P, Di Giovanni P, Gaeta MA et al. Trimetazidine and reduction in mortality and hospitalization in patients with ischemic dilated cardiomyopathy: a post hoc analysis of the Villa Pini d'Abruzzo Trimetazidine Trial. J Cardiovasc Pharmacol 2007; 50: 585-589. Go to original source... Go to PubMed...




Vnitřní lékařství

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.