Vnitr Lek 2010, 56(2):130-137

Antithrombotic therapy in pregnancy

M. Procházka^1,*, J. Procházková², L. Slavík²

¹ Porodnicko-gynekologická klinika Lékařské fakulty UP a FN Olomouc, přednosta doc. MUDr. Radovan Pilka, Ph.D.

² Hematoonkologická klinika Lékařské fakulty UP a FN Olomouc, přednosta prof. MUDr. Karel Indrák, DrSc.

Despite the fact of low prevalence of maternal death, deep venous thrombosis remains one of the most serious complication in pregnancy and puerperium. Virchows triad - vascular stasis, hypercoagulability, and vascular trauma plays the main role in the pathogenesis of deep vein thrombosis in pregnancy. Low molecular weight heparins and unfractionated heparins are the best treatment option. The aim of the treatment is to be effective in extension of thrombus and prevention of the postthrombotic syndrome and pulmonary embolism. Management of pregnant women with increased risk of venous thromboembolism can be stratified by determining whether the prior episode VTE was unprovoked or associated with a transient risk factor and the presence or absence of an inherited thrombophilia.

Keywords: deep vein thrombosis; pulmonary embolism; pregnancy; thrombophilia; heparin

Received: February 9, 2010; Published: February 1, 2010  Show citation