Vnitr Lek 2009, 55(Suppl 1):103-107

Changes to the renal function results following marathon run, a 100-kilometre run and a 24-hour long-term run

M. Mydlík^1,*, K. Derzsiová¹, B. Bohuš²

¹ IV. interná klinika Lekárskej fakulty UPJŠ a FN L. Pasteura Košice, Slovenská republika, prednosta prof. MUDr. Ivan Tkáč, PhD.

² Klinika preventívneho a telovýchovného lekárstva Lekárskej fakulty UPJŠ a FN L. Pasteura Košice, Slovenská republika, prednosta prof. MUDr. Daniel Pella, PhD.

Methods:
Renal function assessment was conducted in 29 marathon runners, 21 runners of a 100-kilometre run and in 7 runners after 24-hour run at a stadium.

Results:
Runners' body weight decreased in marathon runners by 1.3 ± 0.5 kg, in 100-kilometre runners by 2.4 ± 0.7 kg and in 24-hour runners by 4.4 ± 1.1 kg. Blood pressure declined after the first two runs and increased after the 24-hour run. Total proteinuria and albuminuria increased significantly after all three types of run, the least after the 24-hour long-term run. Non-glomerular erythrocyturia was present in the majority of runners after the marathon and 100-kilometre runs and in 2 runners only after the 24-hour run. Creatine kinase, its isoenzyme MB and myoglobin plasma levels increased significantly after all runs. Nevertheless, isoenzyme CK-MB did not exceed 6% of the total catalytic activity. These increases were due to rhabdomyolysis and were associated with myoglobinuria. Urea, creatinine and phosphorus plasma levels and FE_K increased significantly after all three runs, FE_Na, FE_Cl, FE_OSM and FE_H2O decreased. Blood pH was within the reference range during all three runs. Analysis of the base excess and standard bicarbonate after all three runs suggested mild metabolic acidosis.

Conclusion:
The described changes to the renal function results were consequent to dehydration, protein catabolism, reduced elimination of osmotic agents, rhabdomyolysis, rennin-angiotenzin-aldosterone system and other factors. Renal function abnormalities in runners were absent 6-21 days after the marathon run, 100-kilometre run and 24-hour long-term run.

Keywords: renal function result; renal stress response

Received: April 6, 2009; Published: February 1, 2009  Show citation