Vnitr Lek 2007, 53(7-8):816-820

Randomly discovered enlargement in the region of sella turcica

V. Hána^1,*, Z. Seidl², M. Vaněčková², P. Diblík³, V. Weiss¹, V. Masopust⁴, M. Kršek¹, J. Marek¹

¹ III. interní klinika 1. lékařské fakulty UK a VFN Praha, přednosta prof. MUDr. Štěpán Svačina, DrSc., MBA

² Radiodiagnostická klinika 1. lékařské fakulty UK a VFN Praha, přednosta doc. MUDr. Jan Daneš, CSc.

³ Oční klinika 1. lékařské fakulty UK a VFN Praha, přednostka doc. MUDr. Bohdana Kalvodová, CSc.

⁴ Neurochirurgická klinika 1. lékařské fakulty UK a ÚVN Praha, přednosta prof. MUDr. Vladimír Beneš, DrSc.

Computer tomography (CT) and magnetic resonance imaging (MRI) quite often detect unexpected cases of enlargement in the hypothalamus-hypophysial region, without the above methods being indicated for clinical manifested symptomatology provoked by the tumour. This is not surprising if we consider that autopsies show the presence of hypophysial adenomas of 10-15 % of population on an average. X ray, CT or MRI are indicated in the case of head traumas, lateral nasal cavity inflammations, headaches, strokes, neurological diseases and other disorders. A number of tumours of diverse etiology occur in the hypothalamus-hypophysial region, but hypophysial adenomas are by far the most frequent among all (above 90 %). Among other primary enlargements, the most frequent are craniopharyngeomas and meningeomas, while other enlargements are by fare less common. Such randomly detected tumours are mostly asymptomatic, but targeted anamnesis may show some of the symptoms quite clearly. The symptomatology can be linked with possible slight hormonal overproduction of hypophysial adenomas, a deficit of hypophysial hormones or local manifestations of expansion. Exact assessment of MRI results, of hormonal activity of the enlargement, of the relation to surrounding structures, especially the optic nerves, and the assessment of hypophysial functions are important for the therapeutic decision. Depending on the type and extension of the tumour the options considered are pharmacotherapy (the treatment of choice in the case of prolactinomas), surgery, radiotherapy (today prevailingly using the gamma knife), and if no intervention is necessary, follow up with regular MRI examinations. Tumorous growth is more often observed in "macroadenomas" than in "microadenomas" (up to 10 mm).

Keywords: expansion of hypothalamus-hypophysial region; adenoma of hypophysis; incidentalom; hypopituitarism; cephalea; field of vision disorder

Received: March 15, 2007; Published: July 1, 2007  Show citation