Vnitr Lek 2006, 52(5):417-422

Sodium hyaluronate and an iodine complex - Hyiodine® - new method of diabetic defects treatment

L. Sobotka^1,*, V. Velebný², A. Šmahelová¹, M. Kusalová¹

¹ Klinika gerontologická a metabolická Lékařské fakulty UK a FN, Hradec Králové, přednosta prof. MUDr. Luboš Sobotka, CSc.

² Contipro, a.s., Dolní Dobrouč, ředitel RNDr. Vladimír Velebný

Complicated diabetic defects are difficult to heal and frequently result in leg amputation. We have developed a new and unique system for wound treatment, which is based on combination of high molecular weight sodium hyaluronate with an iodine complex - Hyiodine®. The aim of our study was to assess the effect of this new method of wound dressing on infected diabetic defects healing.

Methods:
The effect of Hyiodine® was studied on 22 patients suffering from complicated foot diabetic wounds. Hyiodine® was either spread directly over the wound, or (more frequently) gauze was immersed in Hyiodine® and then put on/into the wound. Then several layers of dry gauze covered the wound.

Results:
Within 2-6 weeks after the onset of treatment all but two defects were filled with granulation tissue. Complete healing was evident in 18 patients within 6-20 weeks after the start of treatment, depending on the wound character, localization and extent. Two patients are still treated by Hyiodine®, and significant improvement is apparent on their wound. Treatment was not successful in two subjects with ischemic defects due to simultaneous arterial occlusion.

Conclusions:
We can conclude that the hyaluronan-iodine complex Hyiodine® is efficient method for treatment of difficult to heal diabetic defects without complete arterial occlusion.

Keywords: wound healing; diabetes mellitus; diabetic ulcer; hyaluronan; iodine; Hyiodine®

Received: November 4, 2005; Accepted: November 4, 2005; Published: May 1, 2006  Show citation