Vnitr Lek 2001, 47(6):381-386

[Apoptosis, its mechanisms and medical significance. I. Definition of apoptosis and its progression at the cellular level].

J Novosad, K Kodydková, J Krejsek
Ustav klinické imunologie a alergologie Lékarské fakulty UK Hradec Králové.

Apoptosis is a one example of genetically-regulated cell death. It is characterized by the phylogenetically highly conserved activation of specific genes and proteins followed by energy-consuming proteolytic autodestruction. Apoptosis seems to be physiological and highly selective mechanism to eliminate either old or injured cells in organisms. It is in contrary to mitosis. A highly complex combination of various stimuli both extracellular and intracellular origins is required for induction of apoptosis together with preserved oxidative phosphorylation.

Keywords: Animals; Apoptosis, physiology, ; Caspases, physiology, ; Cell Death, physiology, ; Humans; Mitochondria, physiology, ; Necrosis; Signal Transduction

Published: June 1, 2001  Show citation

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Novosad J, Kodydková K, Krejsek J. [Apoptosis, its mechanisms and medical significance. I. Definition of apoptosis and its progression at the cellular level]. Vnitr Lek. 2001;47(6):381-386.
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