Vnitr Lek 1999, 45(3):159-162
[Linear regression analysis of values of the calciuria index, N-telopetide and bone mineral density in patients with osteoporosis].
- Osteologická ambulancia, Fakultná NsP akademika L. Dérera, Bratislava.
UNLABELLED: The authors examined 49 patients (n=49) with primary and secndary osteoporosis incl. 37 women aged 41-58 years and 12 men aged 38-56 years. In all they assessed the 24-hour calciuria index (Ca/creatinine), the aminoterminal N-telopetide of collagen I of the organic matrix (NTx24) and the bone mineral density (BMD) in the first three lumbar vertebrae using quantitative computed tomography (QC).
OBJECTIVE: To find an answer to the questions:1. Is the calciuria index in the 24-hour diuresis a parameter which provides information on osteresorption? 2. Is there a significant negative correlation between values NTx24 and BMD? 3. Is NTx a sensitive parameter of osteoresorption in men and women with primary or secondary osteoporosis?
STATISTICAL ANALYSIS: Linear regression analysis.
RESULTS: Correlation coefficients for the correlated groups NTx24 - Ca/creatinine (r = 0.023, p>0.05) and NTx24 - BMD (r = -0.238, p>0.05) were not statistically significant. Statistical significance was recorded in the correlation coefficient for pathologically elevated values of NTx24(zNTx24), correlated with BMD (r = -0.3115, p
Keywords: Adult; Biomarkers, analysis, ; Bone Density; Bone Resorption; Calcium, urine, ; Collagen, urine, ; Collagen Type I; Diuresis; Female; Humans; Linear Models; Male; Middle Aged; Osteoporosis, diagnosis, ; Peptides, urine,
Published: March 1, 1999 Show citation