Vnitr Lek 1998, 44(11):661-664

[Tissue plasminogen activator and diabetes mellitus].

P Galajda, E Martinka, P Kubisz, M Mokán
I. interná klinika MFN, Martin.

tPA has been the independent risk factor of the thrombosis associated with atherosclerosis. There are increased tPA levels in type 1 diabetic patients with vascular complications and tPA is endothelial injury marker in this case. In type 2 diabetes mellitus elevated tPA antigen levels in early disease stage are caused by increased production of complexes with inhibitor (PAI-1) and tPA or fibrinolytic activity has been decreased.

Keywords: Diabetes Mellitus, blood, ; Diabetic Angiopathies, blood, ; Endothelium, Vascular, metabolism, ; Humans; Tissue Plasminogen Activator, metabolism,

Published: November 1, 1998  Show citation

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Galajda P, Martinka E, Kubisz P, Mokán M. [Tissue plasminogen activator and diabetes mellitus]. Vnitr Lek. 1998;44(11):661-664.
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