Vnitr Lek 1997, 43(12):809-814

[High-dose chemotherapy--a new hope for some patients with malignant tumors?].

J Mayer
II. interní klinika FN, Brno Bohunice.

High-dosage chemotherapy is at present a very intensively investigated therapeutic procedure which rises great expectations. Administration of large doses of cytostatics is made possible by subsequent transplantation of autologous or allogenic haematopoietic progenitor cells (transplantation of peripheral stem cells or bone marrow). This reduces markedly the haematological toxicity of chemotherapy and it is possible to administer cytostatics in amounts at the non-haematological toxicity borderline. In the first part of the paper theoretical principles of high-dosage chemotherapy are analyzed, the relationship between the dosage of the drug and its effect. The author describes also cytostatics used in regimens of high dosage chemotherapy and discusses general toxic effects of this treatment.

Keywords: Antineoplastic Agents, administration & dosage, ; Bone Marrow Transplantation; Hematopoietic Stem Cell Transplantation; Humans; Neoplasms, drug therapy,

Published: December 1, 1997  Show citation

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Mayer J. [High-dose chemotherapy--a new hope for some patients with malignant tumors?]. Vnitr Lek. 1997;43(12):809-814.
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