Vnitr Lek 1996, 42(1):7-11

[Levels of lactic acid in type II diabetics treated with buformin].

J Perusicová, J Skrha, A Hodinár, A Bernovská, V Cacáková, A Richtrová

Diabetologická ordinace, interní oddĕlení fakultní polikliniky VFN, Praha.

The objective of the work was to assess the blood lactate levels in type 2 diabetics selected at random, treated for prolonged periods with buformin. 77% of the investigated group of diabetics (N = 70) had elevated blood lactate levels and 16% of them had hyperlactataemia (more than 5.0 mmol/l). In 33% patients with an originally elevated lactataemia after 12 weeks of discontinued buformin treatment the lactic acid blood levels reached normal values. The lactate levels declined significantly (by more than 25% of the original value) after 6 weeks without buformin treatment in another 45% of the diabetic patients. In 18% of the investigated patients, who had high lactate levels even after discontinuation of treatment, in two-thirds neither impaired function of the kidneys and liver nor cardiac disease or alcoholism were detected.

Keywords: Adult; Aged; Buformin, therapeutic use, ; Diabetes Mellitus, Type 2, blood, ; Female; Humans; Hypoglycemic Agents, therapeutic use, ; Lactates, blood, ; Male; Middle Aged

Published: January 1, 1996  Show citation