Vnitr Lek 1994, 40(3):163-166
[Children of parents treated for Hodgkin's disease using irradiation and chemotherapy].
- I. interní klinika 1. LF UK, Praha.
The authors describe data on the course of pregnancy, delivery and subsequent development of 20 children born to parents treated for Hodgkin's disease. Thirteen women in the clinical stage II and III were delivered of 16 infants (10 daughters and 6 sons) and three men (II A and III A) had four daughters. The parents were in one case treated by irradiation only, twice by chemotherapy only and thirteen times by a combination of irradiation and chemotherapy (COPP/ABVD). The gestation period, parameters of the infants at delivery and the subsequent physical and mental development are normal. In one instance (a girl, now ten and a half years old) the child was born with malformations of the extremities; according to the geneticist this is not related to the previous treatment of the mother. The second child (a son) of this mother is normal. The authors are of the opinion and apply it in the therapeutic protocol in patients of fertile age and do not irradiate nodes in the pelvic region. In treated patients they allow pregnancy only after three or preferably five years following terminated treatment. Survival of patients in the whole group (269 subjects) regardless of age and clinical stage is 75%. The authors are processing a data base of Hodgkin patients since 1968.
Keywords: Adult; Antineoplastic Agents, adverse effects, ; Child; Child Development; Child, Preschool; Congenital Abnormalities, etiology, ; Female; Follow-Up Studies; Hodgkin Disease, therapy, ; Humans; Infant; Infant, Newborn; Male; Pelvis, radiation effects, ; Pregnancy; Pregnancy Outcome; Radiotherapy, adverse effects,
Published: March 1, 1994 Show citation