Vnitr Lek 1990, 36(1):45-51
[Electrophysiologic effects of orally administered amiodarone].
- II. Katedra interních oborů, farmakologie a lékarské biochemie lékarské fakulty Univerzity Karlovy, Hradec Králové.
The authors made an invasive electrophysiological examination of the heart before and after administration of amiodarone by the oral route in 18 patients (15 men and 3 women). Amiodarone was administered in maintenance doses of 200 or 400 mg/day for 3 to 13 months (mean 4.7 months). Comparison of values revealed a significant protraction of R-R, P-Q and QRS intervals on the surface ECG. A-H and H-V intervals on the electrogram of the bundle of His as well as effective refractory periods of the ventricular myocardium were significantly protracted. During high-frequency stimulation of the atria the frequency at which an a-v block grade II type I develops declined. No significant changes developed in Q-Tc intervals on the surface ECG, the PA-A on the electrogram of the bundle of His and in the corrected recovery period of the s-a node.
Keywords: Administration, Oral; Adult; Aged; Amiodarone, administration & dosage, ; Bundle of His, drug effects, ; Electrocardiography, drug effects, ; Female; Humans; Male; Middle Aged
Published: January 1, 1990 Show citation