Vnitr Lek 2010, 56(12):1271-1273

Activity of the hypothalamic - pituitary - adrenal axis in patients with rheumatoid arthritis

R. Imrich
Molekulárno-medicínske centrum SAV, Ústav experimentálnej endokrinológie SAV Bratislava, Slovenská republika, riaditeľ prof. MUDr. Iwar Klimeš, DrSc.

The controlled data accumulated so far support only subtle alterations in hypothalamic-pituitary-adrenal (HPA) axis function in rheumatoid arthritis (RA), mainly at the adrenal level, and particularly in a subset of premenopausal onset women. Consequences of the subtle HPA alterations in RA for the disease development remain unclear. From a broader perspective, the unresponsiveness of the HPA axis to chronic inflammation in RA can be simply considered an ongoing adaptation to chronic disease.

Keywords: hypothalamic-pituitary-adrenal axis; rheumatoid arthritis; chronic inflammation

Received: October 1, 2010; Published: December 1, 2010  Show citation

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Imrich R. Activity of the hypothalamic - pituitary - adrenal axis in patients with rheumatoid arthritis. Vnitr Lek. 2010;56(12):1271-1273.
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