Vnitr Lek 2006, 52(7-8):673-676

Gastroduodenal complications associated with non-steroidal anti-inflammatory drugs in Slovak Republic: results of one-year prospective study

I. Rybár1,*, M. Hlísta2, P. Masaryk3, J. Rovenský1,3, R. Hyrdel4, M. Kriška5
1 Katedra reumatológie Fakulty zdravotníctva a špecializačných štúdií Slovenskej zdravotníckej univerzity, Bratislava, Slovenská republika, vedúci prof. MUDr. Jozef Rovenský, DrSc., FRCP
2 Interné oddelenie NsP, Trenčín, Slovenská republika, prednosta prim. MUDr. Oto Herman
3 Národný ústav reumatických chorôb, Piešťany, riaditeľ prof. MUDr. Jozef Rovenský, DrSc., FRCP
4 II. interná klinika Jeseniovej lekárskej fakulty UK a Centrum pre liečbu rezistentných peptických vredov, Martin, Slovenská republika, prednosta prof. MUDr. Rudolf Hyrdel, CSc.
5 Farmakologický ústav Lekárskej fakulty UK, Bratislava, Slovenská republika, vedúci prof. MUDr. Milan Kriška, DrSc.

The aim of the one-year prospective study was to estimate the prevalence of non-steroidal anti-inflammatory drugs using in patients with symptomatic gastroduodenal ulcers, the upper gastrointestinal bleeding and perforation (PUB - perforation, ulcer, bleeding). Among of 326 patients with PUB, prevalence of non-steroidal anti-inflammatory drugs using was 60 %. In the group of 194 patients with non-steroidal antiinflammatory drugs induced PUB, 49 % patients took aspirin, 38 % non-aspirin non-steroidal anti-inflammatory drugs and 13 % their combination. Low dosing aspirin (daily dosis ≤ 200 mg) was associated with PUB in 21 % of patients. Age higher than 60 years and women had statisticaly signiticant higher prevalence of non-steroidal anti-inflammatory drugs induced PUB.

Keywords: non-steroidal anti-inflammatory drugs; peptic ulcer; gastrointestinal bleeding; gastropathy; rheumatic diseases; epidemiology

Received: April 11, 2006; Published: July 1, 2006  Show citation

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Rybár I, Hlísta M, Masaryk P, Rovenský J, Hyrdel R, Kriška M. Gastroduodenal complications associated with non-steroidal anti-inflammatory drugs in Slovak Republic: results of one-year prospective study. Vnitr Lek. 2006;52(7-8):673-676.
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    References

    1. Singh G. Recent consideration in nonsteroidal anti-inflammatory drug gastropathy. Am J Med 1998; 105(Suppl 1): 31S-38S. Go to original source... Go to PubMed...
    2. Garcia Rodriguez LA, Jick H. Risk of upper gastrointestinal bleeding and peroration associated with individual non-steroidal anti-inflammatory drugs. Lancet 1994; 343: 769-772. Go to original source... Go to PubMed...
    3. Forrest JAH, Finlayson NDC, Shaerman DJC. Endoscopy in gastrointestinal bleeding. Lancet 1974; 326: 394-397. Go to original source... Go to PubMed...
    4. Bures J. Gastric and duodenal ulcers - etiopathogenesis, diagnosis and therapy at the milestone of the 20th century. Vnitř Lék 2004; 50(Suppl 1): S91-S93. Go to PubMed...
    5. Kunovská M, Dite P, Lata J et al. Helicobacter pylori negative gastroduodenal lesions in subjects treated with nonsteroidal anti-inflammatory drugs. Vnitř Lék 2000; 46: 384-386. Go to PubMed...
    6. Fialová P, Vlček J. The role of anti-ulcerative drugs in treatment and prevention of gastropathies induced by nonsteroidal anti-inflammatory drugs. Vnitř Lék 2004; 50: 858-866. Go to PubMed...
    7. Lukáš M, Chalupná P. Retrospektivní analýza vlivu nesteroidních antirevmatik na masivní krvácaní do horní části trávici trubice. Prakt Lék 2003; 83: 13-17.
    8. Shostak NA, Riabkova AA, Saveljev VS et al. Gastrointestinal hemorrhages as complications of gastropathies associated with intake of nonsteroidal anti-inflammatory drugs. Ter Arkh 2003; 75: 70-73.
    9. Wilcox CM, Shalek KA, Cotsonis G. Striking prevalence of over-the-counter nonsteroidal anti-inflammatory drug use in patients with upper gastrointestinal haemorrhage. Arch Intern Med 1994; 154: 42-46. Go to original source...
    10. Gutthann SP, Garcia Rodriguez LA, Raiford DS. Individual nonsteroidal anti-inflammatory drugs and other risk factors for upper gastrointestinal bleeding and perforation. Epidemiology 1997; 8: 18-24. Go to original source... Go to PubMed...

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