Vnitr Lek 2005, 51(11):1297-1302
Type 1A diabetes mellitus and autoimmunity
- I. interná klinika Jesseniovej lekárskej fakulty UK a Martinskej FN, Martin, Slovenská republika, prednosta prof. MUDr. Marián Mokáň, DrSc.
Type 1A diabetes mellitus presents the most frequent part of type 1 DM. This disease is caused by an autoimmune destruction of pancreatic β-cells. Genetic, autoimmune and environmental factors are responsible for the development of type 1 diabetes. The most important genes that determinate the development of the disease are genes of Major Histocompatibility Complex (MHC). There is evidence that viral infection acts as a triggering event of autoimmune reaction. The immune response to a microbial determinant would cross-react with host tissues and results in an activation and proliferation of T-lymphocytes that cause destruction of pancreatic β-cells.
Keywords: type 1A diabetes mellitus; HLA-alleles; T-lymphocytes; pancreatic β-cells
Received: January 14, 2005; Accepted: April 20, 2005; Published: November 1, 2005 Show citation
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