Vnitr Lek 2005, 51(1):48-52

Introduction to the metabolic syndrome problematics

M. Souček

II. interní klinika Lékařské fakulty MU a FN u sv. Anny, Brno, přednosta doc. MUDr. Miroslav Souček, CSc.

Metabolic syndrome is easily diagnosable but in each individual patient it should be evaluated in all its relationships. Metabolic syndrome is determined according to the presence of hypertension, obesity, dyslipidemia and the presence of type 2 diabetes mellitus. In addition to the combination of basic clinical disorders, we can find some other metabolic abnormalities, indicating the seriousness of pathophysiologic changes caused by the syndrome. In recent years, the syndrome was widened by other metabolic and fibronolysis disorders. The causes of metabolic syndrome remain unclear. Landsberg et al. determined as a primary pathogenetic mechanism insulinresistance, Julius et al. consider increased activity of central sympethetic nervous system to be crucial. Prevalence ranges from 20 to 40% according to diagnostic criteria. The clinical importance of metabolic syndrome lies in his role in aterosclerosis development. Therefore it is clear that metabolic syndrome therapy should be a complex one, based on non-pharmacologic measures and in majority of cases supplemented by pharmacoltherapy considering all the aspects of metabolic syndrome, in order to achieve a really long-term cardiovasular benefit.

Keywords: metabolic syndrome; insulinresistance; dyslipidemy; hypertension; obesity; cardiovascular diseases

Received: January 14, 2004; Accepted: July 7, 2004; Published: January 1, 2005  Show citation