Vnitr Lek 2026, 72(4):E1-E3 | DOI: 10.36290/vnl.2026.053

Type 2 diabetes mellitus + glaucoma = type 4 diabetes mellitus

Štefan Sotak
KATOS MED, s. r. o., Humenné

The term "type 4 diabetes mellitus (DM)" is not generally recognized. It occurs more in popular science than in professional science literature. However, it is interesting that this term has two meanings, two different definitions. The first definition of this type of diabetes is that it is a type 2 DM that occurs in patients with glaucoma. Although the relationship between any type of glaucoma and any type of DM has been debated in the past, cumulative epidemiological evidence confirms that the risk of developing glaucoma, specifically primary open-angle glaucoma, is increased in the diabetic population. Other types of glaucoma in diabetes have not been studied. Type 4 DM is not understood as a separate type of diabetes, but rather as a collective name for two different diseases, between which there is most likely a connection.

Keywords: type 4 diabetes mellitus, primary open-angle glaucoma, insulin resistance, blindness.

Accepted: June 11, 2026; Published: June 24, 2026  Show citation

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Sotak Š. Type 2 diabetes mellitus + glaucoma = type 4 diabetes mellitus. Vnitr Lek. 2026;72(4):E1-3. doi: 10.36290/vnl.2026.053.
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References

  1. Fichtl M, Růžičková E, Rezková L. Glaukom. In: Heissigerová J, et al., editors. Oftalmologie. Praha: Maxdorf; 2021:251-267.
  2. Lu X, Xie Q, Pan X, et al. Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy. Signal Transduct Target Ther. 2024;9:262. Go to original source... Go to PubMed...
  3. American Diabetes Association Professional Practice Committee. Diagnosis and classification of diabetes: standards of care in diabetes-2024. Diabetes Care. 2024;47(Suppl 1):S20-S42. Go to original source... Go to PubMed...
  4. Jellinger KA. Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia. Neurodegener Dis. 2008;5(3-4):118-121. Go to original source...
  5. Nisar O, Pervez H, Mandalia B, et al. Type 3 Diabetes Mellitus: A Link Between Alzheimer's Disease and Type 2 Diabetes Mellitus. Cureus. 2020;12(11):e11703. Go to original source... Go to PubMed...
  6. Nguyen TT, Ta QTH, Nguyen TKO, et al. Type 3 Diabetes and Its Role Implications in Alzheimer's Disease. Int J Mol Sci. 2020;21(9):3165. Go to original source... Go to PubMed...
  7. Song BJ, Aiello LP, Pasquale LR. Presence and Risk Factors for Glaucoma in Patients with Diabetes. Curr Diab Rep. 2016;16(12):124. Go to original source... Go to PubMed...
  8. Steinmetz JD, Bourne RRA, Briant PS. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study. Lancet Glob Health. 2021;9(2):e144-e160. Go to original source...
  9. Tham YC, Li X, Wong TY, et al. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121(11):2081-2090. Go to original source...
  10. Blázquez E, Velázquez E, Hurtado-Carneiro V, et al. Insulin in the brain: its pathophysiological implications for states related with central insulin resistance, type 2 diabetes and Alzheimer's disease. Front Endocrinol (Lausanne). 2014;5:161. Go to original source... Go to PubMed...
  11. Ito M. Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate. Biochem Biophys Res Commun. 2003;301(2):564-571. Go to original source... Go to PubMed...
  12. Kim JW. Insulin enhances nitric oxide production in trabecular meshwork cells via de novo pathway for tetrahydrobiopterin synthesis. Korean J Ophthalmol. 2007;21(1):39-44. Go to original source...
  13. Montgomery MK, Turner N. Mitochondrial dysfunction and insulin resistance: an update. Endocr Connect. 2015;4(1):R1-R15. Go to original source...
  14. Yoneda S, Hara H, Hirata A, et al. Vitreous fluid levels of beta-amyloid(1-42) and tau in patients with retinal diseases. Jpn J Ophthalmol. 2005;49(2):106-108. Go to original source...
  15. Al-Taee IK, Al-Safar JJ, Al-Falahi YS, et al. The Clinical Significance of β-2-microglobulin in End-Stage Renal Disease. Saudi J Kidney Dis Transpl. 2003;14(4):492-496.
  16. Wang Y, Tian Y, Quan Y, et al. New insights into genetic comorbidity mechanisms: type 2 diabetes and primary open-angle glaucoma. BMJ Open Ophthalmol. 2025;10(1):e002219. Go to original source... Go to PubMed...
  17. King R, Stansfield W. A Dictionary of Genetics. New York: Oxford University Press; 1997:264.
  18. Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545-15550. Go to original source...
  19. Holden M, Deng S, Wojnowski L, et al. GSEA-SNP: applying gene set enrichment analysis to SNP data from genome-wide association studies. Bioinformatics. 2008;24(23):2784-2785. Go to original source... Go to PubMed...
  20. Zhu Q, Sun Y, Zhou Q, et al. Identification of key genes and pathways by bioinformatics analysis with TCGA RNA sequencing data in hepatocellular carcinoma. Mol Clin Oncol. 2018;9(6):597-606. Go to original source... Go to PubMed...
  21. Bu SY, Yu GH, Xu GX. Expression of insulin-like growth factor 1 receptor in rat retina following optic nerve injury. Acta Ophthalmol. 2013;91(6):e427-e431. Go to original source...
  22. Song J, Kang SM, Kim E, et al. Impairment of insulin receptor substrate 1 signaling by insulin resistance inhibits neurite outgrowth and aggravates neuronal cell death. Neuroscience. 2015;301:26-38. Go to original source...
  23. Agostinone J, Alarcon-Martinez L, Gamlin C, et al. Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury. Brain. 2018;141(7):1963-1980. Go to original source...
  24. Bartlett JD, Slusser TG, Turner-Henson A, et al. Toxicity of insulin administered chronically to human eye in vivo. J Ocul Pharmacol. 1994;10(1):101-107. Go to original source... Go to PubMed...
  25. Saxton RA, Sabatini DM. mTOR Signaling in Growth, Metabolism, and Disease. Cell. 2017;168(6):960-976. Go to original source...
  26. Jacinto E, Loewith R, Schmidt A, et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol. 2004;6(11):1122-1128. Go to original source... Go to PubMed...
  27. Thoreen CC, Chantranupong L, Keys HR, et al. A unifying model for mTORC1-mediated regulation of mRNA translation. Nature. 2012;485(7396):109-113. Go to original source... Go to PubMed...
  28. El Hajji S, Shiga Y, Belforte N, et al. Insulin restores retinal ganglion cell functional connectivity and promotes visual recovery in glaucoma. Sci Adv. 2024;10(32):eadl5722. Go to original source...
  29. Saludares M, Wennberg-Smith Z, Beykin G, et al. A Phase I Randomized Trial of Topical Insulin for Glaucoma: Safety and Efficacy Outcomes. Ophthalmol Sci. 2025;6(2):101032. Go to original source...
  30. Molnárová M, Praženicová M. Chronické komplikácie diabetes mellitus a ich manažment. Retinopatia. In: Martinka E, et al., editors. Interdisciplinárne odporúčania pre diagnostiku a liečbu diabetes mellitus, jeho komplikácií a najvýznamnejších sprievodných ochorení - 2021. Forum Diab. 2021;10(Suppl 2):91-93.
  31. Studnička J, Němčanský J, Vysloužilová D, et al. Doporučené postupy pro diagnostiku a léčbu diabetické retinopatie. Čes Slov Oftalmol. 2023;79(5):238-247. Go to original source...




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