Vnitr Lek 2026, 72(4):8 | DOI: 10.36290/vnl.2026.044
Oncological screening in gastroenterology and hepatology
- 1 II. interní klinika - gastroenterologická a geriatrická Fakultní nemocnice Olomouc
- 2 Lékařská fakulta Univerzity Palackého v Olomouci
Gastrointestinal cancers are among the leading causes of death in the Czech Republic. Screening programs focused on the detection of precancerous lesions and early-stage disease play a crucial role in secondary prevention, as they have been proven to reduce mortality and improve overall survival rates. In this review article, we summarize current epidemiological data, etiopathogenesis and screening diagnostic methods for patients with Barrett's esophagus, colorectal cancer (including patients with inflammatory bowel disease), hepatocellular carcinoma in patients with liver cirrhosis and individuals at risk of developing pancreatic cancer.
Keywords: Barrett's esophagus, colorectal cancer, IBD, hepatocellular carcinoma, pancreatic cancer, screening.
Accepted: June 11, 2026; Published: June 24, 2026 Show citation
References
- Kroupa R. Barrettův jícen, rizikové faktory, léčba. Intern Med Praxi. 2012;14(3):104-106.
- SVOD. Incidence. [Internet] [cited 2026 May 18]. Available from: https://www.svod.cz/incidence?form%5Bsubmenu%5D=by_year & form%5BdiagnosisMenus%5D%5 B%5D=155 & form%5Bsex%5D=&form%5Bregion%5D=&form%5BageGroupFrom%5D=&form%5BageGroupTo%5D=&form%5ByearFrom%5D=1977 & form%5ByearTo%5D=2023 & form%5Bcomputing%5D=1 & form%5Bsettings%5D=&form%5Bsend%5D=
- Lukáš K, et al. Refluxní choroba jícnu: Standardy České gastroenterologické společnosti - aktualizace 2009. [Internet]. Česká gastroenterologická společnost; 2009 [cited 2026 May 18]. Available from: https://www.casopisvnitrnilekarstvi.cz/artkey/vnl-200910-0011_gastroesophageal-reflux-disease-standards-of-the-czech-society-of-gastroenterology-actualization-2009.php
- Martínek J, Falt P, Gregar J, et al. Standardy České gastroenterologické společnosti - endoskopická léčba pacientů s Barrettovým jícnem a časnými neoplaziemi jícnu. Gastroent Hepatol. 2013;67(6):479-487.
- Ferlay J, Ervik M, Lam F, et al. Global Cancer Observatory: Cancer Today. [Internet]. Lyon: International Agency for Research on Cancer; 2024 [cited 2026 May 18].
- SVOD. Karty diagnóz C18-C20. [Internet] [cited 2026 May 18]. Available from: https://www.svod.cz/res/file/karty-diagnoz/c18-c20.pdf
- Zavoral M, editor. Mařatkova gastroenterologie: patofyziologie, diagnostika, léčba. 1. vyd. Praha: Univerzita Karlova, Nakladatelství Karolinum; 2021. s. 764. ISBN 978-80-246-5002-9.
- Falt P, et al. Doporučené postupy České gastroenterologické společnosti ČLS JEP pro diagnostickou a terapeutickou koloskopii - aktualizované vydání 2024. Gastroent Hepatol. 2024;78(3):197-235. doi:10.48095/ccgh2024197.
Go to original source... - Zavoral M, editor. Mařatkova gastroenterologie: patofyziologie, diagnostika, léčba. Praha: Univerzita Karlova, Nakladatelství Karolinum; 2021. s. 740-765. ISBN 978-80-246-5002-9.
- East JE, Gordon M, Nigam GB, et al. British Society of Gastroenterology guidelines on colorectal surveillance in inflammatory bowel disease. Gut. 2025;0:1-34. doi:10.1136/gutjnl-2025-335023.
Go to original source... - Zhang L, Zhang X, Su T, et al. Colorectal cancer risk in ulcerative colitis: an updated population-based systematic review and meta-analysis. eClinicalMedicine. 2025;84:103269. doi:10.1016/j.eclinm.2025.103269.
Go to original source... - Falt P, Cyrany J, Kunovský L, et al. Doporučené postupy České gastroenterologické společnosti ČLS JEP pro diagnostickou a terapeutickou koloskopii - aktualizované vydání 2024. Gastroent Hepatol. 2024;78(3):197-235.
- Maaser C, Sturm A, Vavricka SR, et al. ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications. J Crohns Colitis. 2019;13(2):144-164 K.
- Roseira J, Estevinho MM, Gros B, et al. Advances in endoscopy in IBD diagnostics and management. Best Pract Res Clin Gastroenterol. 2025;78:102055. doi:10.1016/j.bpg.2025.102055.
Go to original source... - Bortlík M, Ďuricová D, Hrdlička L, et al. Doporučení Pracovní skupiny pro idiopatické střevní záněty pro diagnostiku a medikamentózní léčbu ulcerózní kolitidy. Gastroent Hepatol. 2022;76(1):13-28.
- SVOD.CZ [Internet] [cited 2026 May 18]. Available from: www.svod.cz
- Martínek J, Trunečka P. Gastroenterologie a hepatologie v algoritmech. Praha: Maxdorf; 2021. s. 653-659. ISBN 978-80-7345-684-9.
- Sangro B, Argemi J, Ronot M, et al. EASL Clinical Practice Guidelines on the management of hepatocellular carcinoma. J Hepatol. 2025;82(2):315-374.
- Gokcen P, Guzelbulut F, Adali G, et al. Validation of the PAGE-B score to predict hepatocellular carcinoma risk in caucasian chronic hepatitis B patients on treatment. World J Gastroenterol. 2022;28(6):665-674. doi:10.3748/wjg.v28.i6.665.
Go to original source... - Singal AG, Llovet JM, Yarchoan M, et al. AASLD Practice Guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma. Hepatology. 2023;78(6):1922-1965. doi:10.1097/hep.0000000000000466.
Go to original source... - Hu H, Zhao Y, He C, et al. Ultrasonography of Hepatocellular Carcinoma: From Diagnosis to Prognosis. J Clin Transl Hepatol. 2024;12(5):516-524. doi:10.14218/jcth.2024.00018.
Go to original source... - Kudo M. Imaging Diagnosis of Hepatocellular Carcinoma and Premalignant/Borderline Lesions. Semin Liver Dis. 1999;19(3):297-309. doi:10.1055/s-2007-1007119.
Go to original source... - Zavoral M, editor. Mařatkova gastroenterologie: patofyziologie, diagnostika, léčba. Praha: Univerzita Karlova, Nakladatelství Karolinum; 2021. s. 885-903. ISBN 978-80-246-5002-9.
- Vaněk P, Andrašina T, Bitnerová???, et al. Pancreatic cancer surveillance in high-risk individuals: Position statement of professional societies. Gastroent Hepatol. 2023;77(6):529-538. doi:10.48095/ccgh2023529.
Go to original source... - Bures J, Kohoutová D, Skrha J, et al. Diabetes mellitus in pancreatic cancer: a distinct approach to older subjects with new-onset diabetes mellitus. Cancers (Basel). 2023;15(14):3669. doi:10.3390/cancers15143669.
Go to original source... - Yang X, Leslie G, Doroszuk A, et al. Cancer Risks Associated With Germline PALB2 Pathogenic Variants: An International Study of 524 Families. J Clin Oncol. 2020;38(7):674-685. doi:10.1200/JCO.19.01907.
Go to original source... - Klein AP, Brune KA, Petersen GM, et al. Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds. Cancer Res. 2004;64(7):2634-2638. doi:10.1158/0008-5472.CAN-03-3823.
Go to original source...




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