Vnitr Lek 2026, 72(3):189-192 | DOI: 10.36290/vnl.2026.039

Pancreatic panniculitis - a cutaneous manifestation of pancreatic disease

David Solil^{1, 2}, Petr Dítě^{1, 2, 3}, Radek Kroupa^{1, 2}, Michal Šenkyřík^{1, 2}, Martin Harazim^{1, 2}, Petr Litzman^{1, 2}, Klára Bochníčková^{1, 2}, Jan Šlapák^{1, 2}, Milan Dastych^{1, 2}, Jiří Dolina^{1, 2}

¹ Interní gastroenterologická klinika, FN Brno

² Lékařská fakulta MU, Brno

³ Lékařská fakulta OU, Ostrava

Pancreatic panniculitis is a rare cutaneous manifestation of pancreatic disease, characterized by painful erythematous nodules predominantly affecting the lower extremities, resulting from the release of pancreatic enzymes into subcutaneous tissue and subsequent fat necrosis. It is most commonly associated with acute pancreatitis but may also occur in the setting of pancreatic malignancy. In some cases, it represents the first clinical manifestation of previously asymptomatic pancreatic disease. This article provides an overview of pancreatic panniculitis, inspired by a case report from our institution.

Keywords: pancreatic panniculitis, acute pancreatitis, chronic pancreatitis, pancreatic cancer, skin lesions.

Accepted: April 23, 2026; Published: May 18, 2026  Show citation