Vnitr Lek 2026, 72(2):118-119 | DOI: 10.36290/vnl.2026.024

Hyperuricemia: Indications for treatment vs. non-treatment according to current guidelines

Zdeněk Monhart
Interní oddělení a urgentní příjem, Nemocnice Znojmo

Pharmacological treatment of hyperuricemia is indicated in patients with clear clinical manifestations such as gout or nephrolithiasis. Current guidelines do not support pharmacotherapy for asymptomatic hyperuricemia, even in the presence of chronic kidney disease (CKD) or cardiovascular disease.

Keywords: asymptomatic hyperuricaemia, gout, CKD.

Accepted: March 25, 2026; Published: April 8, 2026  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Monhart Z. Hyperuricemia: Indications for treatment vs. non-treatment according to current guidelines. Vnitr Lek. 2026;72(2):118-119. doi: 10.36290/vnl.2026.024.
Download citation

References

  1. Mandl P, D'Agostino MA, Navarro-Compán V, et al. 2023 EULAR recommendations on imaging in diagnosis and management of crystal-induced arthropathies in clinical practice. Ann Rheum Dis. 2024 May 15;83(6):752-759. Go to original source...
  2. Richette P, Doherty M, Pascual E, at al. 2016 updated EULAR evidence-based recommendations for the management of gout. Ann Rheum Dis. 2017 Jan;76(1):29-42. Go to original source... Go to PubMed...
  3. FitzGerald JD, Dalbeth N, Mikuls T, at al. 2020 American College of Rheumatology Guideline for the Management of Gout. Arthritis Care Res (Hoboken). 2020 Jun;72(6):744-760. Go to original source... Go to PubMed...
  4. Akram M, Jahrreiss V, Skolarikos A, et al. Urological Guidelines for Kidney Stones: Overview and Comprehensive Update. J Clin Med. 2024 Feb 16;13(4):1114. Go to original source... Go to PubMed...
  5. Skolarikos A, Somani B, Neisius A, et al. Metabolic Evaluation and Recurrence Prevention for Urinary Stone Patients: An EAU Guidelines Update. Eur Urol. 2024 Oct;86(4):343-363. Go to original source... Go to PubMed...
  6. Pearle MS, Goldfarb DS, Assimos DG, et al. Medical management of kidney stones: AUA Guideline. J Urol. 2014;192:316. Go to original source... Go to PubMed...
  7. Perissinotti AJ, Bishop MR, Bubalo J, at al. Expert consensus guidelines for the prophylaxis and management of tumor lysis syndrome in the United States. Cancer Treat Rev. 2023 Nov;120:102603. Go to original source... Go to PubMed...
  8. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024 Apr;105(4S):S117-S314. Go to original source... Go to PubMed...
  9. Visseren FLJ, Mach F, Smulders YM, Carballo D et al.; ESC National Cardiac Societies; ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021 Sep 7;42(34):3227-3337. Go to original source... Go to PubMed...
  10. Which foods are safe for gout? Arthritis Foundation. https://www.arthritis.org/health-wellness/healthy-living/nutrition/healthy-eating/which-foods-are-safe-for-gout. Accessed Feb. 24, 2026.
  11. Stanly EAR, Vilakkathala R, George J. Medication Non-adherence in Older Adults: Underlying Factors, Potential Interventions and Outcomes. Drugs Aging. 2025 Nov;42(11):991-1000. Go to original source... Go to PubMed...




Vnitřní lékařství

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.